DegronMD

Uniprot ID: Q8NHY3

Source protein: GAS2-like protein 2

Source gene: GAS2L2

Class: DEG_SCF_FBW7_1

Location: 512:518

E3 ligase: FBXW7

DEGRON score: 0.9979

ASA_SCORE: 99.7429

COIL: 0.9719

CONS_SCORE: 0.3439

DSS_SCORE: 0.7543

HELIX: 0.0113

FCONS_SCORE: 1.0602

RIG_SCORE: 0.5564

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T523I	TCGA-CC-A123	LIHC	TCGA	PPTPGRS	DEG_SCF_FBW7_1	0.1944
p.T523I	DO23038	LIHC	ICGC	PPTPGRS	DEG_SCF_FBW7_1	0.1944
p.I505N	TCGA-CG-5717	STAD	TCGA	PPTPGRS	DEG_SCF_FBW7_1	0.1389
p.I505N	DO38272	STAD	ICGC	PPTPGRS	DEG_SCF_FBW7_1	0.1389
p.T514K	TCGA-DA-A3F8	SKCM	TCGA	PPTPGRS	DEG_SCF_FBW7_1	0.7306
p.T514K	DO37418	SKCM	ICGC	PPTPGRS	DEG_SCF_FBW7_1	0.7306
p.R511C	TCGA-EB-A6QZ	SKCM	TCGA	PPTPGRS	DEG_SCF_FBW7_1	0.3056
p.R511C	DO48626	SKCM	ICGC	PPTPGRS	DEG_SCF_FBW7_1	0.3056
p.G516E	TCGA-EE-A20C	SKCM	TCGA	PPTPGRS	DEG_SCF_FBW7_1	0.6087
p.G516E	DO222775	MELA	ICGC	PPTPGRS	DEG_SCF_FBW7_1	0.6087
p.G516E	DO47665	SKCM	ICGC	PPTPGRS	DEG_SCF_FBW7_1	0.6087
p.R511H	TCGA-HC-7211	PRAD	TCGA	PPTPGRS	DEG_SCF_FBW7_1	0.3056
p.R511H	DO36287	PRAD	ICGC	PPTPGRS	DEG_SCF_FBW7_1	0.3056
p.S518R	TCGA-L5-A4OE	ESCA	TCGA	PPTPGRS	DEG_SCF_FBW7_1	0.7427
p.T523S	TCGA-NC-A5HT	LUSC	TCGA	PPTPGRS	DEG_SCF_FBW7_1	0.1944
p.T523S	DO219205	LUSC	ICGC	PPTPGRS	DEG_SCF_FBW7_1	0.1944
p.R506W	DO234353	ESAD	ICGC	PPTPGRS	DEG_SCF_FBW7_1	0.1667
p.R506Q	SIDM00715	Non-Small Cell Lung Carcinoma	GDSC	PPTPGRS	DEG_SCF_FBW7_1	0.1667
p.R506Q	ACH-000521	Lung Cancer	CCLE	PPTPGRS	DEG_SCF_FBW7_1	0.1667
p.P509S	SIDM00531	Pancreatic Carcinoma	GDSC	PPTPGRS	DEG_SCF_FBW7_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8NHY3	GAS2-like protein 2	DEG_SCF_FBW7_1	512:518	PPTPGRS	FBXW7	0.9979	More...
Q9H305	Cell death-inducing p53-target protein 1	DEG_SCF_FBW7_1	25:31	PPTPGRS	FBXW7	0.9795	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons