DegronMD

Uniprot ID: Q9H305

Source protein: Cell death-inducing p53-target protein 1

Source gene: CDIP1

Class: DEG_SCF_FBW7_1

Location: 25:31

E3 ligase: FBXW7

DEGRON score: 0.9795

ASA_SCORE: 85.3429

COIL: 0.9731

CONS_SCORE: 0.3592

DSS_SCORE: 0.8025

HELIX: 0.0104

FCONS_SCORE: 0.8671

RIG_SCORE: 0.4842

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R30H	DO233737	GACA	ICGC	PPTPGRS	DEG_SCF_FBW7_1	0.7133
p.P26S	SIDM00499	Prostate Carcinoma	GDSC	PPTPGRS	DEG_SCF_FBW7_1	0.5641
p.P26S	ACH-000956	Prostate Cancer	CCLE	PPTPGRS	DEG_SCF_FBW7_1	0.5641
p.P26S	22RV1	prostate	COSMIC	PPTPGRS	DEG_SCF_FBW7_1	0.5641
p.T41I	ACH-000985	Colon/Colorectal Cancer	CCLE	PPTPGRS	DEG_SCF_FBW7_1	0.0556
p.T41I	LS-411N	large_intestine	COSMIC	PPTPGRS	DEG_SCF_FBW7_1	0.0556
p.S37N	ACH-001203	Lymphoma	CCLE	PPTPGRS	DEG_SCF_FBW7_1	0.1667
p.S37N	SUP-HD1	haematopoietic_and_lymphoid_tissue	COSMIC	PPTPGRS	DEG_SCF_FBW7_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8NHY3	GAS2-like protein 2	DEG_SCF_FBW7_1	512:518	PPTPGRS	FBXW7	0.9979	More...
Q9H305	Cell death-inducing p53-target protein 1	DEG_SCF_FBW7_1	25:31	PPTPGRS	FBXW7	0.9795	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons