DegronMD - Q8TDM6(DLG5)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Data table is loading....

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P1125T	TCGA-17-Z015	LUAD	TCGA	FRPKLAPVV	DEG_APCC_DBOX_1	1119:1127	Mutation altering degron motif	0.5919
p.R1193W	TCGA-4Z-AA81	BLCA	TCGA	LTPSTT	DEG_SCF_FBW7_1	1182:1187	Mutation rewiring degron network	0.1667
p.R1193W	TCGA-BS-A0VI	UCEC	TCGA	LTPSTT	DEG_SCF_FBW7_1	1182:1187	Mutation rewiring degron network	0.1667
p.R1193W	TCGA-EO-A22R	UCEC	TCGA	LTPSTT	DEG_SCF_FBW7_1	1182:1187	Mutation rewiring degron network	0.1667
p.R1193W	DO51868	BLCA	ICGC	LTPSTT	DEG_SCF_FBW7_1	1182:1187	Mutation rewiring degron network	0.1667
p.R1193W	DO41764	UCEC	ICGC	LTPSTT	DEG_SCF_FBW7_1	1182:1187	Mutation rewiring degron network	0.1667
p.R1193W	DO42713	UCEC	ICGC	LTPSTT	DEG_SCF_FBW7_1	1182:1187	Mutation rewiring degron network	0.1667
p.P1125A	TCGA-78-7149	LUAD	TCGA	FRPKLAPVV	DEG_APCC_DBOX_1	1119:1127	Mutation altering degron motif	0.6392
p.P1125A	DO23790	LUAD	ICGC	FRPKLAPVV	DEG_APCC_DBOX_1	1119:1127	Mutation altering degron motif	0.6392
p.R1112Q	TCGA-A5-A0G2	UCEC	TCGA	FRPKLAPVV	DEG_APCC_DBOX_1	1119:1127	Mutation rewiring degron network	0.1389
p.R1112Q	DO41235	UCEC	ICGC	FRPKLAPVV	DEG_APCC_DBOX_1	1119:1127	Mutation rewiring degron network	0.1389
p.R1110H	TCGA-A5-A2K3	UCEC	TCGA	FRPKLAPVV	DEG_APCC_DBOX_1	1119:1127	Mutation rewiring degron network	0.0833
p.R1110H	DO43899	UCEC	ICGC	FRPKLAPVV	DEG_APCC_DBOX_1	1119:1127	Mutation rewiring degron network	0.0833
p.R1110H	SIDM00431	T-Lymphoblastic Leukemia	GDSC	FRPKLAPVV	DEG_APCC_DBOX_1	1119:1127	Mutation rewiring degron network	0.0833
p.R1110H	MOLT-16	haematopoietic and lymphoid tissue	COSMIC	FRPKLAPVV	DEG_APCC_DBOX_1	1119:1127	Mutation rewiring degron network	0.0833
p.R1180W	TCGA-AB-2918	LAML	TCGA	LTPSTT	DEG_SCF_FBW7_1	1182:1187	Mutation rewiring degron network	0.2778
p.R1180W	DO21978	LAML	ICGC	LTPSTT	DEG_SCF_FBW7_1	1182:1187	Mutation rewiring degron network	0.2778
p.R1180G	TCGA-AJ-A3EK	UCEC	TCGA	LTPSTT	DEG_SCF_FBW7_1	1182:1187	Mutation rewiring degron network	0.2778
p.R1180G	DO41584	UCEC	ICGC	LTPSTT	DEG_SCF_FBW7_1	1182:1187	Mutation rewiring degron network	0.2778
p.L1168P	TCGA-AP-A051	UCEC	TCGA	PPLY	ITCH	1166:1169	Mutation altering degron motif	0.6471
p.L1168P	DO42673	UCEC	ICGC	PPLY	ITCH	1166:1169	Mutation altering degron motif	0.6471
p.R1180L	TCGA-BF-A1PZ	SKCM	TCGA	LTPSTT	DEG_SCF_FBW7_1	1182:1187	Mutation rewiring degron network	0.2778
p.R1180L	DO50279	SKCM	ICGC	LTPSTT	DEG_SCF_FBW7_1	1182:1187	Mutation rewiring degron network	0.2778
p.R1193L	TCGA-D3-A2JK	SKCM	TCGA	LTPSTT	DEG_SCF_FBW7_1	1182:1187	Mutation rewiring degron network	0.1667
p.R1193L	DO37619	SKCM	ICGC	LTPSTT	DEG_SCF_FBW7_1	1182:1187	Mutation rewiring degron network	0.1667
p.V1126L	TCGA-DU-6404	LGG	TCGA	FRPKLAPVV	DEG_APCC_DBOX_1	1119:1127	Mutation altering degron motif	0.5654
p.V1126L	DO22207	LGG	ICGC	FRPKLAPVV	DEG_APCC_DBOX_1	1119:1127	Mutation altering degron motif	0.5654
p.V795I	TCGA-EE-A3AC	SKCM	TCGA	PQSSS	DEG_SPOP_SBC_1	797:801	Mutation rewiring degron network	0.2778
p.V795I	DO37631	SKCM	ICGC	PQSSS	DEG_SPOP_SBC_1	797:801	Mutation rewiring degron network	0.2778
p.P1173L	TCGA-GN-A4U7	SKCM	TCGA	LTPSTT	DEG_SCF_FBW7_1	1182:1187	Mutation rewiring degron network	0.0833
p.P1173L	TCGA-GN-A4U7	SKCM	TCGA	PPLY	ITCH	1166:1169	Mutation rewiring degron network	0.2222
p.P1173L	TCGA-HU-A4G6	STAD	TCGA	LTPSTT	DEG_SCF_FBW7_1	1182:1187	Mutation rewiring degron network	0.0833
p.P1173L	TCGA-HU-A4G6	STAD	TCGA	PPLY	ITCH	1166:1169	Mutation rewiring degron network	0.2222
p.P1173L	ACH-000526	Non-Cancerous	CCLE	LTPSTT	DEG_SCF_FBW7_1	1182:1187	Mutation rewiring degron network	0.0833
p.P1173L	ACH-000526	Non-Cancerous	CCLE	PPLY	ITCH	1166:1169	Mutation rewiring degron network	0.2222
p.P1173S	TCGA-GN-A4U7	SKCM	TCGA	LTPSTT	DEG_SCF_FBW7_1	1182:1187	Mutation rewiring degron network	0.0833
p.P1173S	TCGA-GN-A4U7	SKCM	TCGA	PPLY	ITCH	1166:1169	Mutation rewiring degron network	0.2222
p.P1173S	DO51258	SKCM	ICGC	LTPSTT	DEG_SCF_FBW7_1	1182:1187	Mutation rewiring degron network	0.0833
p.P1173S	DO51258	SKCM	ICGC	PPLY	ITCH	1166:1169	Mutation rewiring degron network	0.2222
p.R1120W	TCGA-GN-A8LK	SKCM	TCGA	FRPKLAPVV	DEG_APCC_DBOX_1	1119:1127	Mutation altering degron motif	0.8634
p.R1120W	DO51259	SKCM	ICGC	FRPKLAPVV	DEG_APCC_DBOX_1	1119:1127	Mutation altering degron motif	0.8634
p.R1120W	SIDM00705	Non-Cancerous	GDSC	FRPKLAPVV	DEG_APCC_DBOX_1	1119:1127	Mutation altering degron motif	0.8634
p.R1120W	SIDM00706	Small Cell Lung Carcinoma	GDSC	FRPKLAPVV	DEG_APCC_DBOX_1	1119:1127	Mutation altering degron motif	0.8634
p.R1112L	TCGA-QR-A6H3	PCPG	TCGA	FRPKLAPVV	DEG_APCC_DBOX_1	1119:1127	Mutation rewiring degron network	0.1389
p.S1174F	TCGA-W3-A824	SKCM	TCGA	LTPSTT	DEG_SCF_FBW7_1	1182:1187	Mutation rewiring degron network	0.1111
p.S1174F	TCGA-W3-A824	SKCM	TCGA	PPLY	ITCH	1166:1169	Mutation rewiring degron network	0.1944
p.P1170S	TCGA-W3-AA1R	SKCM	TCGA	PPLY	ITCH	1166:1169	Mutation rewiring degron network	0.3056
p.P1170S	DO51275	SKCM	ICGC	PPLY	ITCH	1166:1169	Mutation rewiring degron network	0.3056
p.E1135K	DO51891	BLCA	ICGC	FRPKLAPVV	DEG_APCC_DBOX_1	1119:1127	Mutation rewiring degron network	0.1111
p.K1166R	DO14950	HNSC	ICGC	PPLY	ITCH	1166:1169	Mutation altering degron motif	0.7237
p.E1122Q	DO15158	HNSC	ICGC	FRPKLAPVV	DEG_APCC_DBOX_1	1119:1127	Mutation altering degron motif	0.6744
p.Q810L	DO228278	LICA	ICGC	PQSSS	DEG_SPOP_SBC_1	797:801	Mutation rewiring degron network	0.0833
p.T1186A	DO228353	MALY	ICGC	LTPSTT	DEG_SCF_FBW7_1	1182:1187	Mutation altering degron motif	0.6028
p.P1166T	DO228403	MALY	ICGC	PPLY	ITCH	1166:1169	Mutation altering degron motif	0.7031
p.P797S	DO220903	MELA	ICGC	PQSSS	DEG_SPOP_SBC_1	797:801	Mutation altering degron motif	0.6752
p.E1122K	DO222696	MELA	ICGC	FRPKLAPVV	DEG_APCC_DBOX_1	1119:1127	Mutation altering degron motif	0.7022
p.P1184S	DO232761	PBCA	ICGC	LTPSTT	DEG_SCF_FBW7_1	1182:1187	Mutation altering degron motif	0.6752
p.G804D	DO232761	PBCA	ICGC	PQSSS	DEG_SPOP_SBC_1	797:801	Mutation rewiring degron network	0.25
p.S791F	DO229453	SKCA	ICGC	PQSSS	DEG_SPOP_SBC_1	797:801	Mutation blocking phosphorylation signal	0.6111
p.P800S	DO37406	SKCM	ICGC	PQSSS	DEG_SPOP_SBC_1	797:801	Mutation altering degron motif	0.6752
p.Q1133H	DO229259	THCA	ICGC	FRPKLAPVV	DEG_APCC_DBOX_1	1119:1127	Mutation rewiring degron network	0.1667
p.V1188M	SIDM00654	Small Cell Lung Carcinoma	GDSC	LTPSTT	DEG_SCF_FBW7_1	1182:1187	Mutation rewiring degron network	0.3056
p.V1188M	ACH-000866	Lung Cancer	CCLE	LTPSTT	DEG_SCF_FBW7_1	1182:1187	Mutation rewiring degron network	0.3056
p.V1188M	NCI-H1048	lung	COSMIC	LTPSTT	DEG_SCF_FBW7_1	1182:1187	Mutation rewiring degron network	0.3056
p.S801L	SIDM01136	Pancreatic Carcinoma	GDSC	PQSSS	DEG_SPOP_SBC_1	797:801	Mutation altering degron motif	0.7667
p.S801L	PANC-08-13	pancreas	COSMIC	PQSSS	DEG_SPOP_SBC_1	797:801	Mutation altering degron motif	0.7667
p.N806K	SIDM00999	Bladder Carcinoma	GDSC	PQSSS	DEG_SPOP_SBC_1	797:801	Mutation rewiring degron network	0.1944
p.N806K	ACH-000973	Bladder Cancer	CCLE	PQSSS	DEG_SPOP_SBC_1	797:801	Mutation rewiring degron network	0.1944
p.N806K	639-V	urinary tract	COSMIC	PQSSS	DEG_SPOP_SBC_1	797:801	Mutation rewiring degron network	0.1944
p.R1111H	SIDM00217	Colorectal Carcinoma	GDSC	FRPKLAPVV	DEG_APCC_DBOX_1	1119:1127	Mutation rewiring degron network	0.1111
p.R1111H	ACH-000999	Colon/Colorectal Cancer	CCLE	FRPKLAPVV	DEG_APCC_DBOX_1	1119:1127	Mutation rewiring degron network	0.1111
p.R1111H	SNU-1040	large intestine	COSMIC	FRPKLAPVV	DEG_APCC_DBOX_1	1119:1127	Mutation rewiring degron network	0.1111
p.P1173Q	SIDM01609	Endometrial Carcinoma	GDSC	LTPSTT	DEG_SCF_FBW7_1	1182:1187	Mutation rewiring degron network	0.0833
p.P1173Q	SIDM01609	Endometrial Carcinoma	GDSC	PPLY	ITCH	1166:1169	Mutation rewiring degron network	0.2222
p.P1173Q	ACH-000972	Endometrial/Uterine Cancer	CCLE	LTPSTT	DEG_SCF_FBW7_1	1182:1187	Mutation rewiring degron network	0.0833
p.P1173Q	ACH-000972	Endometrial/Uterine Cancer	CCLE	PPLY	ITCH	1166:1169	Mutation rewiring degron network	0.2222
p.A1130S	ACH-001850	Gallbladder Cancer	CCLE	FRPKLAPVV	DEG_APCC_DBOX_1	1119:1127	Mutation rewiring degron network	0.25
p.H1163N	MLMA	haematopoietic and lymphoid tissue	COSMIC	PPLY	ITCH	1166:1169	Mutation rewiring degron network	0.25

Kaplan plot for DLG5 in

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

DLG5

UniProt ID: Q8TDM6

Entrez ID: 9231

Protein name: Disks large homolog 5 (Discs large protein P-dlg) (Placenta and prostate DLG)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for DLG5 in