DegronMD

Uniprot ID: Q8TDM6

Source protein: Disks large homolog 5

Source gene: DLG5

Class: DEG_SCF_FBW7_1

Location: 1182:1187

E3 ligase: FBXW7

DEGRON score: 0.9993

ASA_SCORE: 80.2667

COIL: 0.9153

CONS_SCORE: 0.3946

DSS_SCORE: 0.5129

HELIX: 0.0387

FCONS_SCORE: 1.155

RIG_SCORE: 0.6979

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R1193W	TCGA-4Z-AA81	BLCA	TCGA	LTPSTT	DEG_SCF_FBW7_1	0.1667
p.R1193W	TCGA-BS-A0VI	UCEC	TCGA	LTPSTT	DEG_SCF_FBW7_1	0.1667
p.R1193W	TCGA-EO-A22R	UCEC	TCGA	LTPSTT	DEG_SCF_FBW7_1	0.1667
p.R1193W	DO51868	BLCA	ICGC	LTPSTT	DEG_SCF_FBW7_1	0.1667
p.R1193W	DO41764	UCEC	ICGC	LTPSTT	DEG_SCF_FBW7_1	0.1667
p.R1193W	DO42713	UCEC	ICGC	LTPSTT	DEG_SCF_FBW7_1	0.1667
p.R1180W	TCGA-AB-2918	LAML	TCGA	LTPSTT	DEG_SCF_FBW7_1	0.2778
p.R1180W	DO21978	LAML	ICGC	LTPSTT	DEG_SCF_FBW7_1	0.2778
p.R1180G	TCGA-AJ-A3EK	UCEC	TCGA	LTPSTT	DEG_SCF_FBW7_1	0.2778
p.R1180G	DO41584	UCEC	ICGC	LTPSTT	DEG_SCF_FBW7_1	0.2778
p.R1180L	TCGA-BF-A1PZ	SKCM	TCGA	LTPSTT	DEG_SCF_FBW7_1	0.2778
p.R1180L	DO50279	SKCM	ICGC	LTPSTT	DEG_SCF_FBW7_1	0.2778
p.R1193L	TCGA-D3-A2JK	SKCM	TCGA	LTPSTT	DEG_SCF_FBW7_1	0.1667
p.R1193L	DO37619	SKCM	ICGC	LTPSTT	DEG_SCF_FBW7_1	0.1667
p.P1173L	TCGA-GN-A4U7	SKCM	TCGA	LTPSTT	DEG_SCF_FBW7_1	0.0833
p.P1173L	TCGA-HU-A4G6	STAD	TCGA	LTPSTT	DEG_SCF_FBW7_1	0.0833
p.P1173L	ACH-000526	Non-Cancerous	CCLE	LTPSTT	DEG_SCF_FBW7_1	0.0833
p.P1173S	TCGA-GN-A4U7	SKCM	TCGA	LTPSTT	DEG_SCF_FBW7_1	0.0833
p.P1173S	DO51258	SKCM	ICGC	LTPSTT	DEG_SCF_FBW7_1	0.0833
p.S1174F	TCGA-W3-A824	SKCM	TCGA	LTPSTT	DEG_SCF_FBW7_1	0.1111
p.T1186A	DO228353	MALY	ICGC	LTPSTT	DEG_SCF_FBW7_1	0.6028
p.P1184S	DO232761	PBCA	ICGC	LTPSTT	DEG_SCF_FBW7_1	0.6752
p.V1188M	SIDM00654	Small Cell Lung Carcinoma	GDSC	LTPSTT	DEG_SCF_FBW7_1	0.3056
p.V1188M	ACH-000866	Lung Cancer	CCLE	LTPSTT	DEG_SCF_FBW7_1	0.3056
p.V1188M	NCI-H1048	lung	COSMIC	LTPSTT	DEG_SCF_FBW7_1	0.3056
p.P1173Q	SIDM01609	Endometrial Carcinoma	GDSC	LTPSTT	DEG_SCF_FBW7_1	0.0833
p.P1173Q	ACH-000972	Endometrial/Uterine Cancer	CCLE	LTPSTT	DEG_SCF_FBW7_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8TDM6	Disks large homolog 5	DEG_SCF_FBW7_1	1182:1187	LTPSTT	FBXW7	0.9993	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LTPSTT

Degron related mutations and impact score

Drug responses associated with DLG5 mutations

All proteins holding degron of LTPSTT