DegronMD

Uniprot ID: Q8TDM6

Source protein: Disks large homolog 5

Source gene: DLG5

Class: DEG_APCC_DBOX_1

Location: 1119:1127

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9585

ASA_SCORE: 99.3333

COIL: 0.9122

CONS_SCORE: 0.3646

DSS_SCORE: 0.4522

HELIX: 0.0348

FCONS_SCORE: 0.9759

RIG_SCORE: 0.727

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P1125T	TCGA-17-Z015	LUAD	TCGA	FRPKLAPVV	DEG_APCC_DBOX_1	0.5919
p.P1125A	TCGA-78-7149	LUAD	TCGA	FRPKLAPVV	DEG_APCC_DBOX_1	0.6392
p.P1125A	DO23790	LUAD	ICGC	FRPKLAPVV	DEG_APCC_DBOX_1	0.6392
p.R1112Q	TCGA-A5-A0G2	UCEC	TCGA	FRPKLAPVV	DEG_APCC_DBOX_1	0.1389
p.R1112Q	DO41235	UCEC	ICGC	FRPKLAPVV	DEG_APCC_DBOX_1	0.1389
p.R1110H	TCGA-A5-A2K3	UCEC	TCGA	FRPKLAPVV	DEG_APCC_DBOX_1	0.0833
p.R1110H	DO43899	UCEC	ICGC	FRPKLAPVV	DEG_APCC_DBOX_1	0.0833
p.R1110H	SIDM00431	T-Lymphoblastic Leukemia	GDSC	FRPKLAPVV	DEG_APCC_DBOX_1	0.0833
p.R1110H	MOLT-16	haematopoietic_and_lymphoid_tissue	COSMIC	FRPKLAPVV	DEG_APCC_DBOX_1	0.0833
p.V1126L	TCGA-DU-6404	LGG	TCGA	FRPKLAPVV	DEG_APCC_DBOX_1	0.5654
p.V1126L	DO22207	LGG	ICGC	FRPKLAPVV	DEG_APCC_DBOX_1	0.5654
p.R1120W	TCGA-GN-A8LK	SKCM	TCGA	FRPKLAPVV	DEG_APCC_DBOX_1	0.8634
p.R1120W	DO51259	SKCM	ICGC	FRPKLAPVV	DEG_APCC_DBOX_1	0.8634
p.R1120W	SIDM00705	Non-Cancerous	GDSC	FRPKLAPVV	DEG_APCC_DBOX_1	0.8634
p.R1120W	SIDM00706	Small Cell Lung Carcinoma	GDSC	FRPKLAPVV	DEG_APCC_DBOX_1	0.8634
p.R1112L	TCGA-QR-A6H3	PCPG	TCGA	FRPKLAPVV	DEG_APCC_DBOX_1	0.1389
p.E1135K	DO51891	BLCA	ICGC	FRPKLAPVV	DEG_APCC_DBOX_1	0.1111
p.E1122Q	DO15158	HNSC	ICGC	FRPKLAPVV	DEG_APCC_DBOX_1	0.6744
p.E1122K	DO222696	MELA	ICGC	FRPKLAPVV	DEG_APCC_DBOX_1	0.7022
p.Q1133H	DO229259	THCA	ICGC	FRPKLAPVV	DEG_APCC_DBOX_1	0.1667
p.R1111H	SIDM00217	Colorectal Carcinoma	GDSC	FRPKLAPVV	DEG_APCC_DBOX_1	0.1111
p.R1111H	ACH-000999	Colon/Colorectal Cancer	CCLE	FRPKLAPVV	DEG_APCC_DBOX_1	0.1111
p.R1111H	SNU-1040	large_intestine	COSMIC	FRPKLAPVV	DEG_APCC_DBOX_1	0.1111
p.A1130S	ACH-001850	Gallbladder Cancer	CCLE	FRPKLAPVV	DEG_APCC_DBOX_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8TDM6	Disks large homolog 5	DEG_APCC_DBOX_1	1119:1127	FRPKLAPVV	APC,CDC20,FZR1	0.9585	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: FRPKLAPVV

Degron related mutations and impact score

Drug responses associated with DLG5 mutations

All proteins holding degron of FRPKLAPVV