DegronMD - Q9BWV1(BOC)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.D287N	TCGA-06-5416	GBM	TCGA	TRFLLSNLL	DEG_APCC_DBOX_1	277:285	Mutation rewiring degron network	0.2778
p.D287N	TCGA-EY-A1GX	UCEC	TCGA	TRFLLSNLL	DEG_APCC_DBOX_1	277:285	Mutation rewiring degron network	0.2778
p.D287N	DO10880	GBM	ICGC	TRFLLSNLL	DEG_APCC_DBOX_1	277:285	Mutation rewiring degron network	0.2778
p.D287N	DO41967	UCEC	ICGC	TRFLLSNLL	DEG_APCC_DBOX_1	277:285	Mutation rewiring degron network	0.2778
p.R278L	TCGA-17-Z010	LUAD	TCGA	TRFLLSNLL	DEG_APCC_DBOX_1	277:285	Mutation altering degron motif	0.8428
p.R602C	TCGA-2Y-A9GT	LIHC	TCGA	PQSSS	DEG_SPOP_SBC_1	592:596	Mutation rewiring degron network	0.1667
p.R602C	DO219506	LIHC	ICGC	PQSSS	DEG_SPOP_SBC_1	592:596	Mutation rewiring degron network	0.1667
p.M549T	TCGA-43-A56V	LUSC	TCGA	HRLTLTRLD	DEG_APCC_DBOX_1	532:540	Mutation rewiring degron network	0.0833
p.M549T	DO45535	LUSC	ICGC	HRLTLTRLD	DEG_APCC_DBOX_1	532:540	Mutation rewiring degron network	0.0833
p.R533H	TCGA-76-6282	GBM	TCGA	HRLTLTRLD	DEG_APCC_DBOX_1	532:540	Mutation altering degron motif	0.8244
p.R533H	DO230315	COCA	ICGC	HRLTLTRLD	DEG_APCC_DBOX_1	532:540	Mutation altering degron motif	0.8244
p.R533H	DO10965	GBM	ICGC	HRLTLTRLD	DEG_APCC_DBOX_1	532:540	Mutation altering degron motif	0.8244
p.R533H	DO228138	PBCA	ICGC	HRLTLTRLD	DEG_APCC_DBOX_1	532:540	Mutation altering degron motif	0.8244
p.R533H	MDA-MB-330	breast	COSMIC	HRLTLTRLD	DEG_APCC_DBOX_1	532:540	Mutation altering degron motif	0.8244
p.G273C	TCGA-77-7141	LUSC	TCGA	TRFLLSNLL	DEG_APCC_DBOX_1	277:285	Mutation rewiring degron network	0.2222
p.G273C	DO26450	LUSC	ICGC	TRFLLSNLL	DEG_APCC_DBOX_1	277:285	Mutation rewiring degron network	0.2222
p.R1021C	TCGA-A5-A0GA	UCEC	TCGA	LQPHHD	LIG_APCC_ABBA_1	1012:1017	Mutation rewiring degron network	0.2222
p.R1021C	DO43763	UCEC	ICGC	LQPHHD	LIG_APCC_ABBA_1	1012:1017	Mutation rewiring degron network	0.2222
p.A1027D	TCGA-AA-3984	COAD	TCGA	LQPHHD	LIG_APCC_ABBA_1	1012:1017	Mutation rewiring degron network	0.0556
p.A1027D	DO9002	COAD	ICGC	LQPHHD	LIG_APCC_ABBA_1	1012:1017	Mutation rewiring degron network	0.0556
p.Q531P	TCGA-AZ-4615	COAD	TCGA	HRLTLTRLD	DEG_APCC_DBOX_1	532:540	Mutation rewiring degron network	0.3056
p.Q531P	DO7977	COAD	ICGC	HRLTLTRLD	DEG_APCC_DBOX_1	532:540	Mutation rewiring degron network	0.3056
p.P605S	TCGA-CK-6746	COAD	TCGA	PQSSS	DEG_SPOP_SBC_1	592:596	Mutation rewiring degron network	0.0833
p.P605S	DO7938	COAD	ICGC	PQSSS	DEG_SPOP_SBC_1	592:596	Mutation rewiring degron network	0.0833
p.A529V	TCGA-CN-A497	HNSC	TCGA	HRLTLTRLD	DEG_APCC_DBOX_1	532:540	Mutation rewiring degron network	0.25
p.A529V	DO218992	HNSC	ICGC	HRLTLTRLD	DEG_APCC_DBOX_1	532:540	Mutation rewiring degron network	0.25
p.S543C	TCGA-DD-AAEI	LIHC	TCGA	HRLTLTRLD	DEG_APCC_DBOX_1	532:540	Mutation rewiring degron network	0.25
p.S543C	DO219575	LIHC	ICGC	HRLTLTRLD	DEG_APCC_DBOX_1	532:540	Mutation rewiring degron network	0.25
p.E292G	TCGA-EY-A215	UCEC	TCGA	TRFLLSNLL	DEG_APCC_DBOX_1	277:285	Mutation rewiring degron network	0.1389
p.E292G	DO42665	UCEC	ICGC	TRFLLSNLL	DEG_APCC_DBOX_1	277:285	Mutation rewiring degron network	0.1389
p.T1002I	TCGA-KQ-A41P	BLCA	TCGA	LQPHHD	LIG_APCC_ABBA_1	1012:1017	Mutation rewiring degron network	0.0556
p.T1002I	DO223590	BLCA	ICGC	LQPHHD	LIG_APCC_ABBA_1	1012:1017	Mutation rewiring degron network	0.0556
p.V271I	TCGA-UF-A71E	HNSC	TCGA	TRFLLSNLL	DEG_APCC_DBOX_1	277:285	Mutation rewiring degron network	0.1667
p.V271I	DO52110	HNSC	ICGC	TRFLLSNLL	DEG_APCC_DBOX_1	277:285	Mutation rewiring degron network	0.1667
p.V271I	DO232224	PBCA	ICGC	TRFLLSNLL	DEG_APCC_DBOX_1	277:285	Mutation rewiring degron network	0.1667
p.H1009D	TCGA-XF-A9SM	BLCA	TCGA	LQPHHD	LIG_APCC_ABBA_1	1012:1017	Mutation rewiring degron network	0.25
p.H1009D	DO223597	BLCA	ICGC	LQPHHD	LIG_APCC_ABBA_1	1012:1017	Mutation rewiring degron network	0.25
p.R602H	DO233908	GACA	ICGC	PQSSS	DEG_SPOP_SBC_1	592:596	Mutation rewiring degron network	0.1667
p.R538I	DO228874	LICA	ICGC	HRLTLTRLD	DEG_APCC_DBOX_1	532:540	Mutation altering degron motif	0.6991
p.G526C	DO52171	LIHC	ICGC	HRLTLTRLD	DEG_APCC_DBOX_1	532:540	Mutation rewiring degron network	0.1667
p.L281P	DO23482	LINC	ICGC	TRFLLSNLL	DEG_APCC_DBOX_1	277:285	Mutation altering degron motif	0.7582
p.G601S	DO222843	MELA	ICGC	PQSSS	DEG_SPOP_SBC_1	592:596	Mutation rewiring degron network	0.1944
p.G601S	DO38727	STAD	ICGC	PQSSS	DEG_SPOP_SBC_1	592:596	Mutation rewiring degron network	0.1944
p.S525C	DO50662	ORCA	ICGC	HRLTLTRLD	DEG_APCC_DBOX_1	532:540	Mutation rewiring degron network	0.1389
p.I583M	DO50662	ORCA	ICGC	PQSSS	DEG_SPOP_SBC_1	592:596	Mutation rewiring degron network	0.0833
p.R533C	DO33552	PACA	ICGC	HRLTLTRLD	DEG_APCC_DBOX_1	532:540	Mutation altering degron motif	0.8301
p.R533C	NCI-H2023	lung	COSMIC	HRLTLTRLD	DEG_APCC_DBOX_1	532:540	Mutation altering degron motif	0.8301
p.D541E	SIDM01163	Non-Small Cell Lung Carcinoma	GDSC	HRLTLTRLD	DEG_APCC_DBOX_1	532:540	Mutation rewiring degron network	0.3056
p.D541E	SW1573	lung	COSMIC	HRLTLTRLD	DEG_APCC_DBOX_1	532:540	Mutation rewiring degron network	0.3056
p.D1018N	SIDM00084	Glioblastoma	GDSC	LQPHHD	LIG_APCC_ABBA_1	1012:1017	Mutation rewiring degron network	0.3056
p.D1018N	SF295	central nervous system	COSMIC	LQPHHD	LIG_APCC_ABBA_1	1012:1017	Mutation rewiring degron network	0.3056
p.R1022H	SIDM00416	B-Cell Non-Hodgkin's Lymphoma	GDSC	LQPHHD	LIG_APCC_ABBA_1	1012:1017	Mutation rewiring degron network	0.1944
p.R1022H	VAL	haematopoietic and lymphoid tissue	COSMIC	LQPHHD	LIG_APCC_ABBA_1	1012:1017	Mutation rewiring degron network	0.1944
p.S270R	SIDM00411	Pancreatic Carcinoma	GDSC	TRFLLSNLL	DEG_APCC_DBOX_1	277:285	Mutation rewiring degron network	0.1389
p.S270R	SIDM00292	Small Cell Lung Carcinoma	GDSC	TRFLLSNLL	DEG_APCC_DBOX_1	277:285	Mutation rewiring degron network	0.1389
p.S270R	SIDM00498	Colorectal Carcinoma	GDSC	TRFLLSNLL	DEG_APCC_DBOX_1	277:285	Mutation rewiring degron network	0.1389
p.S270R	SIDM00616	Hepatocellular Carcinoma	GDSC	TRFLLSNLL	DEG_APCC_DBOX_1	277:285	Mutation rewiring degron network	0.1389
p.S270R	SIDM00579	Neuroblastoma	GDSC	TRFLLSNLL	DEG_APCC_DBOX_1	277:285	Mutation rewiring degron network	0.1389
p.S270R	SIDM00233	T-Lymphoblastic Leukemia	GDSC	TRFLLSNLL	DEG_APCC_DBOX_1	277:285	Mutation rewiring degron network	0.1389
p.S270R	SIDM01444	Glioblastoma	GDSC	TRFLLSNLL	DEG_APCC_DBOX_1	277:285	Mutation rewiring degron network	0.1389
p.S270R	ATN-1	haematopoietic and lymphoid tissue	COSMIC	TRFLLSNLL	DEG_APCC_DBOX_1	277:285	Mutation rewiring degron network	0.1389
p.S270R	LU-165	lung	COSMIC	TRFLLSNLL	DEG_APCC_DBOX_1	277:285	Mutation rewiring degron network	0.1389
p.S270R	YAPC	pancreas	COSMIC	TRFLLSNLL	DEG_APCC_DBOX_1	277:285	Mutation rewiring degron network	0.1389
p.S270R	JHH-4	liver	COSMIC	TRFLLSNLL	DEG_APCC_DBOX_1	277:285	Mutation rewiring degron network	0.1389
p.D293G	SIDM00789	Colorectal Carcinoma	GDSC	TRFLLSNLL	DEG_APCC_DBOX_1	277:285	Mutation rewiring degron network	0.1111
p.D293G	ACH-000997	Colon/Colorectal Cancer	CCLE	TRFLLSNLL	DEG_APCC_DBOX_1	277:285	Mutation rewiring degron network	0.1111
p.D293G	HCT-15	large intestine	COSMIC	TRFLLSNLL	DEG_APCC_DBOX_1	277:285	Mutation rewiring degron network	0.1111
p.T272N	SIDM00156	Neuroblastoma	GDSC	TRFLLSNLL	DEG_APCC_DBOX_1	277:285	Mutation rewiring degron network	0.1944
p.R534H	SIDM00631	Breast Carcinoma	GDSC	HRLTLTRLD	DEG_APCC_DBOX_1	532:540	Mutation altering degron motif	0.8244
p.R534H	MDA-MB-330	breast	COSMIC	HRLTLTRLD	DEG_APCC_DBOX_1	532:540	Mutation altering degron motif	0.8244
p.R534C	SIDM00753	Squamous Cell Lung Carcinoma	GDSC	HRLTLTRLD	DEG_APCC_DBOX_1	532:540	Mutation altering degron motif	0.8301
p.R534C	NCI-H2023	lung	COSMIC	HRLTLTRLD	DEG_APCC_DBOX_1	532:540	Mutation altering degron motif	0.8301
p.E292Q	SIDM00844	Burkitt's Lymphoma	GDSC	TRFLLSNLL	DEG_APCC_DBOX_1	277:285	Mutation rewiring degron network	0.1389
p.E292Q	ACH-000654	Lymphoma	CCLE	TRFLLSNLL	DEG_APCC_DBOX_1	277:285	Mutation rewiring degron network	0.1389
p.E292Q	Raji	haematopoietic and lymphoid tissue	COSMIC	TRFLLSNLL	DEG_APCC_DBOX_1	277:285	Mutation rewiring degron network	0.1389
p.Q585R	SIDM00280	Gastric Carcinoma	GDSC	PQSSS	DEG_SPOP_SBC_1	592:596	Mutation rewiring degron network	0.1389
p.D1017N	ACH-000376	Brain Cancer	CCLE	LQPHHD	LIG_APCC_ABBA_1	1012:1017	Mutation altering degron motif	0.6932
p.D1017N	SF295	central nervous system	COSMIC	LQPHHD	LIG_APCC_ABBA_1	1012:1017	Mutation altering degron motif	0.6932
p.D540E	ACH-000677	Lung Cancer	CCLE	HRLTLTRLD	DEG_APCC_DBOX_1	532:540	Mutation altering degron motif	0.5647
p.D540E	SW1573	lung	COSMIC	HRLTLTRLD	DEG_APCC_DBOX_1	532:540	Mutation altering degron motif	0.5647
p.R1021H	ACH-001703	Lymphoma	CCLE	LQPHHD	LIG_APCC_ABBA_1	1012:1017	Mutation rewiring degron network	0.2222
p.R1021H	VAL	haematopoietic and lymphoid tissue	COSMIC	LQPHHD	LIG_APCC_ABBA_1	1012:1017	Mutation rewiring degron network	0.2222
p.V271D	ACH-002287	Colon/Colorectal Cancer	CCLE	TRFLLSNLL	DEG_APCC_DBOX_1	277:285	Mutation rewiring degron network	0.1667
p.V271D	NCI-H630	large intestine	COSMIC	TRFLLSNLL	DEG_APCC_DBOX_1	277:285	Mutation rewiring degron network	0.1667

DegronMD: protein-targeted degradation, mutation and drug response to degrons

BOC

UniProt ID: Q9BWV1

Entrez ID: 91653

Protein name: Brother of CDO (Protein BOC)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for BOC in