DegronMD

Uniprot ID: Q9BWV1

Source protein: Brother of CDO

Source gene: BOC

Class: LIG_APCC_ABBA_1

Location: 1012:1017

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9641

ASA_SCORE: 80.7

COIL: 0.74

CONS_SCORE: 0.3549

DSS_SCORE: 0.6435

HELIX: 0.1843

FCONS_SCORE: 0.9928

RIG_SCORE: 0.7199

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R1021C	TCGA-A5-A0GA	UCEC	TCGA	LQPHHD	LIG_APCC_ABBA_1	0.2222
p.R1021C	DO43763	UCEC	ICGC	LQPHHD	LIG_APCC_ABBA_1	0.2222
p.A1027D	TCGA-AA-3984	COAD	TCGA	LQPHHD	LIG_APCC_ABBA_1	0.0556
p.A1027D	DO9002	COAD	ICGC	LQPHHD	LIG_APCC_ABBA_1	0.0556
p.T1002I	TCGA-KQ-A41P	BLCA	TCGA	LQPHHD	LIG_APCC_ABBA_1	0.0556
p.T1002I	DO223590	BLCA	ICGC	LQPHHD	LIG_APCC_ABBA_1	0.0556
p.H1009D	TCGA-XF-A9SM	BLCA	TCGA	LQPHHD	LIG_APCC_ABBA_1	0.25
p.H1009D	DO223597	BLCA	ICGC	LQPHHD	LIG_APCC_ABBA_1	0.25
p.D1018N	SIDM00084	Glioblastoma	GDSC	LQPHHD	LIG_APCC_ABBA_1	0.3056
p.D1018N	SF295	central_nervous_system	COSMIC	LQPHHD	LIG_APCC_ABBA_1	0.3056
p.R1022H	SIDM00416	B-Cell Non-Hodgkin's Lymphoma	GDSC	LQPHHD	LIG_APCC_ABBA_1	0.1944
p.R1022H	VAL	haematopoietic_and_lymphoid_tissue	COSMIC	LQPHHD	LIG_APCC_ABBA_1	0.1944
p.D1017N	ACH-000376	Brain Cancer	CCLE	LQPHHD	LIG_APCC_ABBA_1	0.6932
p.D1017N	SF295	central_nervous_system	COSMIC	LQPHHD	LIG_APCC_ABBA_1	0.6932
p.R1021H	ACH-001703	Lymphoma	CCLE	LQPHHD	LIG_APCC_ABBA_1	0.2222
p.R1021H	VAL	haematopoietic_and_lymphoid_tissue	COSMIC	LQPHHD	LIG_APCC_ABBA_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9BWV1	Brother of CDO	LIG_APCC_ABBA_1	1012:1017	LQPHHD	APC,CDC20,FZR1	0.9641	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons