DegronMD

Uniprot ID: Q9BWV1

Source protein: Brother of CDO

Source gene: BOC

Class: DEG_APCC_DBOX_1

Location: 277:285

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9392

ASA_SCORE: 54.6444

COIL: 0.2566

CONS_SCORE: 0.6432

DSS_SCORE: 0.2745

HELIX: 0.0116

FCONS_SCORE: 1.2583

RIG_SCORE: 0.8844

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D287N	TCGA-06-5416	GBM	TCGA	TRFLLSNLL	DEG_APCC_DBOX_1	0.2778
p.D287N	TCGA-EY-A1GX	UCEC	TCGA	TRFLLSNLL	DEG_APCC_DBOX_1	0.2778
p.D287N	DO10880	GBM	ICGC	TRFLLSNLL	DEG_APCC_DBOX_1	0.2778
p.D287N	DO41967	UCEC	ICGC	TRFLLSNLL	DEG_APCC_DBOX_1	0.2778
p.R278L	TCGA-17-Z010	LUAD	TCGA	TRFLLSNLL	DEG_APCC_DBOX_1	0.8428
p.G273C	TCGA-77-7141	LUSC	TCGA	TRFLLSNLL	DEG_APCC_DBOX_1	0.2222
p.G273C	DO26450	LUSC	ICGC	TRFLLSNLL	DEG_APCC_DBOX_1	0.2222
p.E292G	TCGA-EY-A215	UCEC	TCGA	TRFLLSNLL	DEG_APCC_DBOX_1	0.1389
p.E292G	DO42665	UCEC	ICGC	TRFLLSNLL	DEG_APCC_DBOX_1	0.1389
p.V271I	TCGA-UF-A71E	HNSC	TCGA	TRFLLSNLL	DEG_APCC_DBOX_1	0.1667
p.V271I	DO52110	HNSC	ICGC	TRFLLSNLL	DEG_APCC_DBOX_1	0.1667
p.V271I	DO232224	PBCA	ICGC	TRFLLSNLL	DEG_APCC_DBOX_1	0.1667
p.L281P	DO23482	LINC	ICGC	TRFLLSNLL	DEG_APCC_DBOX_1	0.7582
p.S270R	SIDM00411	Pancreatic Carcinoma	GDSC	TRFLLSNLL	DEG_APCC_DBOX_1	0.1389
p.S270R	SIDM00292	Small Cell Lung Carcinoma	GDSC	TRFLLSNLL	DEG_APCC_DBOX_1	0.1389
p.S270R	SIDM00498	Colorectal Carcinoma	GDSC	TRFLLSNLL	DEG_APCC_DBOX_1	0.1389
p.S270R	SIDM00616	Hepatocellular Carcinoma	GDSC	TRFLLSNLL	DEG_APCC_DBOX_1	0.1389
p.S270R	SIDM00579	Neuroblastoma	GDSC	TRFLLSNLL	DEG_APCC_DBOX_1	0.1389
p.S270R	SIDM00233	T-Lymphoblastic Leukemia	GDSC	TRFLLSNLL	DEG_APCC_DBOX_1	0.1389
p.S270R	SIDM01444	Glioblastoma	GDSC	TRFLLSNLL	DEG_APCC_DBOX_1	0.1389
p.S270R	ATN-1	haematopoietic_and_lymphoid_tissue	COSMIC	TRFLLSNLL	DEG_APCC_DBOX_1	0.1389
p.S270R	LU-165	lung	COSMIC	TRFLLSNLL	DEG_APCC_DBOX_1	0.1389
p.S270R	YAPC	pancreas	COSMIC	TRFLLSNLL	DEG_APCC_DBOX_1	0.1389
p.S270R	JHH-4	liver	COSMIC	TRFLLSNLL	DEG_APCC_DBOX_1	0.1389
p.D293G	SIDM00789	Colorectal Carcinoma	GDSC	TRFLLSNLL	DEG_APCC_DBOX_1	0.1111
p.D293G	ACH-000997	Colon/Colorectal Cancer	CCLE	TRFLLSNLL	DEG_APCC_DBOX_1	0.1111
p.D293G	HCT-15	large_intestine	COSMIC	TRFLLSNLL	DEG_APCC_DBOX_1	0.1111
p.T272N	SIDM00156	Neuroblastoma	GDSC	TRFLLSNLL	DEG_APCC_DBOX_1	0.1944
p.E292Q	SIDM00844	Burkitt's Lymphoma	GDSC	TRFLLSNLL	DEG_APCC_DBOX_1	0.1389
p.E292Q	ACH-000654	Lymphoma	CCLE	TRFLLSNLL	DEG_APCC_DBOX_1	0.1389
p.E292Q	Raji	haematopoietic_and_lymphoid_tissue	COSMIC	TRFLLSNLL	DEG_APCC_DBOX_1	0.1389
p.V271D	ACH-002287	Colon/Colorectal Cancer	CCLE	TRFLLSNLL	DEG_APCC_DBOX_1	0.1667
p.V271D	NCI-H630	large_intestine	COSMIC	TRFLLSNLL	DEG_APCC_DBOX_1	0.1667

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: TRFLLSNLL

Degron related mutations and impact score

Drug responses associated with BOC mutations

All proteins holding degron of TRFLLSNLL

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9BWV1	Brother of CDO	DEG_APCC_DBOX_1	277:285	TRFLLSNLL	APC,CDC20,FZR1	0.9392	More...