DegronMD

Uniprot ID: Q9BWV1

Source protein: Brother of CDO

Source gene: BOC

Class: DEG_APCC_DBOX_1

Location: 532:540

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7156

ASA_SCORE: 53.2667

COIL: 0.3656

CONS_SCORE: 0.3343

DSS_SCORE: 0.31

HELIX: 0.004

FCONS_SCORE: 1.002

RIG_SCORE: 0.8118

Degron related mutations and impact score

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R533C	DO33552	PACA	ICGC	HRLTLTRLD	DEG_APCC_DBOX_1	0.8301
p.R533C	NCI-H2023	lung	COSMIC	HRLTLTRLD	DEG_APCC_DBOX_1	0.8301
p.R534C	SIDM00753	Squamous Cell Lung Carcinoma	GDSC	HRLTLTRLD	DEG_APCC_DBOX_1	0.8301
p.R534C	NCI-H2023	lung	COSMIC	HRLTLTRLD	DEG_APCC_DBOX_1	0.8301
p.R533H	TCGA-76-6282	GBM	TCGA	HRLTLTRLD	DEG_APCC_DBOX_1	0.8244
p.R533H	DO230315	COCA	ICGC	HRLTLTRLD	DEG_APCC_DBOX_1	0.8244
p.R533H	DO10965	GBM	ICGC	HRLTLTRLD	DEG_APCC_DBOX_1	0.8244
p.R533H	DO228138	PBCA	ICGC	HRLTLTRLD	DEG_APCC_DBOX_1	0.8244
p.R533H	MDA-MB-330	breast	COSMIC	HRLTLTRLD	DEG_APCC_DBOX_1	0.8244
p.R534H	SIDM00631	Breast Carcinoma	GDSC	HRLTLTRLD	DEG_APCC_DBOX_1	0.8244
p.R534H	MDA-MB-330	breast	COSMIC	HRLTLTRLD	DEG_APCC_DBOX_1	0.8244
p.R538I	DO228874	LICA	ICGC	HRLTLTRLD	DEG_APCC_DBOX_1	0.6991
p.D540E	ACH-000677	Lung Cancer	CCLE	HRLTLTRLD	DEG_APCC_DBOX_1	0.5647
p.D540E	SW1573	lung	COSMIC	HRLTLTRLD	DEG_APCC_DBOX_1	0.5647
p.Q531P	TCGA-AZ-4615	COAD	TCGA	HRLTLTRLD	DEG_APCC_DBOX_1	0.3056
p.Q531P	DO7977	COAD	ICGC	HRLTLTRLD	DEG_APCC_DBOX_1	0.3056
p.D541E	SIDM01163	Non-Small Cell Lung Carcinoma	GDSC	HRLTLTRLD	DEG_APCC_DBOX_1	0.3056
p.D541E	SW1573	lung	COSMIC	HRLTLTRLD	DEG_APCC_DBOX_1	0.3056
p.A529V	TCGA-CN-A497	HNSC	TCGA	HRLTLTRLD	DEG_APCC_DBOX_1	0.25
p.A529V	DO218992	HNSC	ICGC	HRLTLTRLD	DEG_APCC_DBOX_1	0.25
p.S543C	TCGA-DD-AAEI	LIHC	TCGA	HRLTLTRLD	DEG_APCC_DBOX_1	0.25
p.S543C	DO219575	LIHC	ICGC	HRLTLTRLD	DEG_APCC_DBOX_1	0.25
p.G526C	DO52171	LIHC	ICGC	HRLTLTRLD	DEG_APCC_DBOX_1	0.1667
p.S525C	DO50662	ORCA	ICGC	HRLTLTRLD	DEG_APCC_DBOX_1	0.1389
p.M549T	TCGA-43-A56V	LUSC	TCGA	HRLTLTRLD	DEG_APCC_DBOX_1	0.0833

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Drug responses associated with BOC mutations

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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All proteins holding degron of HRLTLTRLD

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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9BWV1	Brother of CDO	DEG_APCC_DBOX_1	532:540	HRLTLTRLD	APC,CDC20,FZR1	0.7156	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: HRLTLTRLD

Degron related mutations and impact score

Drug responses associated with BOC mutations

All proteins holding degron of HRLTLTRLD