DegronMD - Q2TAZ0(ATG2A)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Data table is loading....

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S745C	TCGA-33-AASD	LUSC	TCGA	PQSSS	DEG_SPOP_SBC_1	742:746	Mutation altering degron motif	0.7541
p.S745C	DO219127	LUSC	ICGC	PQSSS	DEG_SPOP_SBC_1	742:746	Mutation altering degron motif	0.7541
p.E237K	TCGA-AJ-A3EL	UCEC	TCGA	VRLHYE	LIG_APCC_ABBA_1	232:237	Mutation altering degron motif	0.7022
p.E237K	DO41542	UCEC	ICGC	VRLHYE	LIG_APCC_ABBA_1	232:237	Mutation altering degron motif	0.7022
p.E237K	ACH-002396	Bone Cancer	CCLE	VRLHYE	LIG_APCC_ABBA_1	232:237	Mutation altering degron motif	0.7022
p.E237K	Sarc9371	bone	COSMIC	VRLHYE	LIG_APCC_ABBA_1	232:237	Mutation altering degron motif	0.7022
p.S746N	TCGA-BG-A222	UCEC	TCGA	PQSSS	DEG_SPOP_SBC_1	742:746	Mutation altering degron motif	0.7069
p.S746N	DO42977	UCEC	ICGC	PQSSS	DEG_SPOP_SBC_1	742:746	Mutation altering degron motif	0.7069
p.W749C	TCGA-BP-4801	KIRC	TCGA	PQSSS	DEG_SPOP_SBC_1	742:746	Mutation rewiring degron network	0.25
p.W749C	DO18066	KIRC	ICGC	PQSSS	DEG_SPOP_SBC_1	742:746	Mutation rewiring degron network	0.25
p.Q735P	TCGA-BR-6852	STAD	TCGA	PQSSS	DEG_SPOP_SBC_1	742:746	Mutation rewiring degron network	0.1389
p.Q735P	DO38202	STAD	ICGC	PQSSS	DEG_SPOP_SBC_1	742:746	Mutation rewiring degron network	0.1389
p.P753Q	TCGA-EB-A24D	SKCM	TCGA	PQSSS	DEG_SPOP_SBC_1	742:746	Mutation rewiring degron network	0.1389
p.P753Q	DO37440	SKCM	ICGC	PQSSS	DEG_SPOP_SBC_1	742:746	Mutation rewiring degron network	0.1389
p.P742L	TCGA-ER-A2NH	SKCM	TCGA	PQSSS	DEG_SPOP_SBC_1	742:746	Mutation altering degron motif	0.7582
p.P742L	DO47683	SKCM	ICGC	PQSSS	DEG_SPOP_SBC_1	742:746	Mutation altering degron motif	0.7582
p.S745R	TCGA-X6-A7WA	SARC	TCGA	PQSSS	DEG_SPOP_SBC_1	742:746	Mutation altering degron motif	0.7427
p.S745R	DO220312	SARC	ICGC	PQSSS	DEG_SPOP_SBC_1	742:746	Mutation altering degron motif	0.7427
p.Q735H	DO234164	ESAD	ICGC	PQSSS	DEG_SPOP_SBC_1	742:746	Mutation rewiring degron network	0.1389
p.S744F	DO222595	MELA	ICGC	PQSSS	DEG_SPOP_SBC_1	742:746	Mutation altering degron motif	0.7982
p.Q242L	DO229216	THCA	ICGC	VRLHYE	LIG_APCC_ABBA_1	232:237	Mutation rewiring degron network	0.1944
p.F732L	SIDM00963	Breast Carcinoma	GDSC	PQSSS	DEG_SPOP_SBC_1	742:746	Mutation rewiring degron network	0.0556
p.F732L	BT-474	breast	COSMIC	PQSSS	DEG_SPOP_SBC_1	742:746	Mutation rewiring degron network	0.0556
p.G231E	SIDM01182	Bladder Carcinoma	GDSC	VRLHYE	LIG_APCC_ABBA_1	232:237	Mutation rewiring degron network	0.3056
p.G231E	ACH-000522	Bladder Cancer	CCLE	VRLHYE	LIG_APCC_ABBA_1	232:237	Mutation rewiring degron network	0.3056
p.G231E	UM-UC-3	urinary tract	COSMIC	VRLHYE	LIG_APCC_ABBA_1	232:237	Mutation rewiring degron network	0.3056
p.R233C	ACH-000398	Lymphoma	CCLE	VRLHYE	LIG_APCC_ABBA_1	232:237	Mutation altering degron motif	0.719
p.D224V	H2369	pleura	COSMIC	VRLHYE	LIG_APCC_ABBA_1	232:237	Mutation rewiring degron network	0.1111

Kaplan plot for ATG2A in

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ATG2A

UniProt ID: Q2TAZ0

Entrez ID: 23130

Protein name: Autophagy-related protein 2 homolog A

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for ATG2A in