DegronMD

Uniprot ID: Q2TAZ0

Source protein: Autophagy-related protein 2 homolog A

Source gene: ATG2A

Class: LIG_APCC_ABBA_1

Location: 232:237

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5653

ASA_SCORE: 52.8

COIL: 0.088

CONS_SCORE: 0.3356

DSS_SCORE: 0.356

HELIX: 0.0088

FCONS_SCORE: 1.0437

RIG_SCORE: 0.7777

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E237K	TCGA-AJ-A3EL	UCEC	TCGA	VRLHYE	LIG_APCC_ABBA_1	0.7022
p.E237K	DO41542	UCEC	ICGC	VRLHYE	LIG_APCC_ABBA_1	0.7022
p.E237K	ACH-002396	Bone Cancer	CCLE	VRLHYE	LIG_APCC_ABBA_1	0.7022
p.E237K	Sarc9371	bone	COSMIC	VRLHYE	LIG_APCC_ABBA_1	0.7022
p.Q242L	DO229216	THCA	ICGC	VRLHYE	LIG_APCC_ABBA_1	0.1944
p.G231E	SIDM01182	Bladder Carcinoma	GDSC	VRLHYE	LIG_APCC_ABBA_1	0.3056
p.G231E	ACH-000522	Bladder Cancer	CCLE	VRLHYE	LIG_APCC_ABBA_1	0.3056
p.G231E	UM-UC-3	urinary_tract	COSMIC	VRLHYE	LIG_APCC_ABBA_1	0.3056
p.R233C	ACH-000398	Lymphoma	CCLE	VRLHYE	LIG_APCC_ABBA_1	0.719
p.D224V	H2369	pleura	COSMIC	VRLHYE	LIG_APCC_ABBA_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q2TAZ0	Autophagy-related protein 2 homolog A	LIG_APCC_ABBA_1	232:237	VRLHYE	APC,CDC20,FZR1	0.5653	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons