DegronMD - Q5TCM9(LCE5A)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R73M	TCGA-17-Z031	LUAD	TCGA	PQSSS	DEG_SPOP_SBC_1	82:86	Mutation rewiring degron network	0.0833
p.G89V	TCGA-A5-A0G2	UCEC	TCGA	PQSSS	DEG_SPOP_SBC_1	82:86	Mutation rewiring degron network	0.25
p.G89V	DO41235	UCEC	ICGC	PQSSS	DEG_SPOP_SBC_1	82:86	Mutation rewiring degron network	0.25
p.R75C	TCGA-AA-3663	COAD	TCGA	PQSSS	DEG_SPOP_SBC_1	82:86	Mutation rewiring degron network	0.1389
p.R75C	DO9346	COAD	ICGC	PQSSS	DEG_SPOP_SBC_1	82:86	Mutation rewiring degron network	0.1389
p.R81Q	TCGA-AN-A0AK	BRCA	TCGA	PQSSS	DEG_SPOP_SBC_1	82:86	Mutation rewiring degron network	0.3056
p.R81Q	DO1608	BRCA	ICGC	PQSSS	DEG_SPOP_SBC_1	82:86	Mutation rewiring degron network	0.3056
p.R79Q	TCGA-AP-A1DV	UCEC	TCGA	PQSSS	DEG_SPOP_SBC_1	82:86	Mutation rewiring degron network	0.25
p.R79Q	TCGA-E6-A1LX	UCEC	TCGA	PQSSS	DEG_SPOP_SBC_1	82:86	Mutation rewiring degron network	0.25
p.R79Q	TCGA-EO-A22X	UCEC	TCGA	PQSSS	DEG_SPOP_SBC_1	82:86	Mutation rewiring degron network	0.25
p.R79Q	TCGA-FG-7638	LGG	TCGA	PQSSS	DEG_SPOP_SBC_1	82:86	Mutation rewiring degron network	0.25
p.R79Q	DO41020	UCEC	ICGC	PQSSS	DEG_SPOP_SBC_1	82:86	Mutation rewiring degron network	0.25
p.R79Q	DO43186	UCEC	ICGC	PQSSS	DEG_SPOP_SBC_1	82:86	Mutation rewiring degron network	0.25
p.R79Q	DO43907	UCEC	ICGC	PQSSS	DEG_SPOP_SBC_1	82:86	Mutation rewiring degron network	0.25
p.R75H	TCGA-CM-6679	COAD	TCGA	PQSSS	DEG_SPOP_SBC_1	82:86	Mutation rewiring degron network	0.1389
p.R75H	DO8272	COAD	ICGC	PQSSS	DEG_SPOP_SBC_1	82:86	Mutation rewiring degron network	0.1389
p.G93S	TCGA-D6-A6ES	HNSC	TCGA	PQSSS	DEG_SPOP_SBC_1	82:86	Mutation rewiring degron network	0.1389
p.G93S	DO52086	HNSC	ICGC	PQSSS	DEG_SPOP_SBC_1	82:86	Mutation rewiring degron network	0.1389
p.S77F	TCGA-EB-A5UM	SKCM	TCGA	PQSSS	DEG_SPOP_SBC_1	82:86	Mutation rewiring degron network	0.1944
p.S77F	DO47282	SKCM	ICGC	PQSSS	DEG_SPOP_SBC_1	82:86	Mutation rewiring degron network	0.1944
p.S90N	TCGA-EO-A3KX	UCEC	TCGA	PQSSS	DEG_SPOP_SBC_1	82:86	Mutation rewiring degron network	0.2222
p.S90N	DO219774	UCEC	ICGC	PQSSS	DEG_SPOP_SBC_1	82:86	Mutation rewiring degron network	0.2222
p.R80H	TCGA-FI-A2D0	UCEC	TCGA	PQSSS	DEG_SPOP_SBC_1	82:86	Mutation rewiring degron network	0.2778
p.R80H	DO43891	UCEC	ICGC	PQSSS	DEG_SPOP_SBC_1	82:86	Mutation rewiring degron network	0.2778
p.R80S	TCGA-NJ-A4YQ	LUAD	TCGA	PQSSS	DEG_SPOP_SBC_1	82:86	Mutation rewiring degron network	0.2778
p.R80S	DO218944	LUAD	ICGC	PQSSS	DEG_SPOP_SBC_1	82:86	Mutation rewiring degron network	0.2778
p.R81L	DO229018	LICA	ICGC	PQSSS	DEG_SPOP_SBC_1	82:86	Mutation rewiring degron network	0.3056
p.S84I	DO229036	LICA	ICGC	PQSSS	DEG_SPOP_SBC_1	82:86	Mutation altering degron motif	0.7341
p.S86I	SIDM00946	T-Lymphoblastic Leukemia	GDSC	PQSSS	DEG_SPOP_SBC_1	82:86	Mutation altering degron motif	0.7341
p.S86I	ACH-000981	Leukemia	CCLE	PQSSS	DEG_SPOP_SBC_1	82:86	Mutation altering degron motif	0.7341
p.S86I	DND-41	haematopoietic and lymphoid tissue	COSMIC	PQSSS	DEG_SPOP_SBC_1	82:86	Mutation altering degron motif	0.7341
p.Q76L	SIDM00356	Non-Small Cell Lung Carcinoma	GDSC	PQSSS	DEG_SPOP_SBC_1	82:86	Mutation rewiring degron network	0.1667
p.Q76L	ACH-000482	Lung Cancer	CCLE	PQSSS	DEG_SPOP_SBC_1	82:86	Mutation rewiring degron network	0.1667
p.Q76L	RERF-LC-KJ	lung	COSMIC	PQSSS	DEG_SPOP_SBC_1	82:86	Mutation rewiring degron network	0.1667

DegronMD: protein-targeted degradation, mutation and drug response to degrons

LCE5A

UniProt ID: Q5TCM9

Entrez ID: 254910

Protein name: Late cornified envelope protein 5A (Late envelope protein 18) (Small proline-rich-like epidermal differentiation complex protein 5A)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for LCE5A in