DegronMD - Q6PJT7(ZC3H14)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R731Q	TCGA-06-5416	GBM	TCGA	PRHALKWIR	DEG_APCC_DBOX_1	723:731	Mutation altering degron motif	0.6218
p.R731Q	TCGA-BS-A0V4	UCEC	TCGA	PRHALKWIR	DEG_APCC_DBOX_1	723:731	Mutation altering degron motif	0.6218
p.R731Q	SIDM00118	Colorectal Carcinoma	GDSC	PRHALKWIR	DEG_APCC_DBOX_1	723:731	Mutation altering degron motif	0.6218
p.R731Q	HCC2998	large intestine	COSMIC	PRHALKWIR	DEG_APCC_DBOX_1	723:731	Mutation altering degron motif	0.6218
p.N142D	TCGA-2Y-A9H7	LIHC	TCGA	VSTSS	DEG_SPOP_SBC_1	131:135	Mutation rewiring degron network	0.1389
p.N142D	DO219533	LIHC	ICGC	VSTSS	DEG_SPOP_SBC_1	131:135	Mutation rewiring degron network	0.1389
p.E537K	TCGA-3B-A9HO	SARC	TCGA	PPGY	ITCH	528:531	Mutation rewiring degron network	0.1667
p.E537K	DO219929	SARC	ICGC	PPGY	ITCH	528:531	Mutation rewiring degron network	0.1667
p.F714L	TCGA-55-7726	LUAD	TCGA	PRHALKWIR	DEG_APCC_DBOX_1	723:731	Mutation rewiring degron network	0.0833
p.P529S	TCGA-75-5126	LUAD	TCGA	PPGY	ITCH	528:531	Mutation altering degron motif	0.6752
p.P529S	DO23711	LUAD	ICGC	PPGY	ITCH	528:531	Mutation altering degron motif	0.6752
p.A122S	TCGA-93-8067	LUAD	TCGA	VSTSS	DEG_SPOP_SBC_1	131:135	Mutation rewiring degron network	0.0833
p.A122S	DO25113	LUAD	ICGC	VSTSS	DEG_SPOP_SBC_1	131:135	Mutation rewiring degron network	0.0833
p.Q432K	TCGA-A5-A0G2	UCEC	TCGA	QRQLLSRLQ	DEG_APCC_DBOX_1	430:438	Mutation altering degron motif	0.5833
p.S135L	TCGA-AP-A1E0	UCEC	TCGA	VSTSS	DEG_SPOP_SBC_1	131:135	Mutation altering degron motif	0.7667
p.S135L	TCGA-AX-A05Z	UCEC	TCGA	VSTSS	DEG_SPOP_SBC_1	131:135	Mutation altering degron motif	0.7667
p.S135L	TCGA-B5-A11N	UCEC	TCGA	VSTSS	DEG_SPOP_SBC_1	131:135	Mutation altering degron motif	0.7667
p.S135L	TCGA-EO-A22U	UCEC	TCGA	VSTSS	DEG_SPOP_SBC_1	131:135	Mutation altering degron motif	0.7667
p.S135L	TCGA-EO-A22X	UCEC	TCGA	VSTSS	DEG_SPOP_SBC_1	131:135	Mutation altering degron motif	0.7667
p.S135L	DO40884	UCEC	ICGC	VSTSS	DEG_SPOP_SBC_1	131:135	Mutation altering degron motif	0.7667
p.S135L	DO43154	UCEC	ICGC	VSTSS	DEG_SPOP_SBC_1	131:135	Mutation altering degron motif	0.7667
p.S135L	DO43907	UCEC	ICGC	VSTSS	DEG_SPOP_SBC_1	131:135	Mutation altering degron motif	0.7667
p.S135L	DO43755	UCEC	ICGC	VSTSS	DEG_SPOP_SBC_1	131:135	Mutation altering degron motif	0.7667
p.S135L	DO41458	UCEC	ICGC	VSTSS	DEG_SPOP_SBC_1	131:135	Mutation altering degron motif	0.7667
p.A122E	TCGA-B0-4700	KIRC	TCGA	VSTSS	DEG_SPOP_SBC_1	131:135	Mutation rewiring degron network	0.0833
p.A122E	DO16961	KIRC	ICGC	VSTSS	DEG_SPOP_SBC_1	131:135	Mutation rewiring degron network	0.0833
p.T521A	TCGA-B5-A3FC	UCEC	TCGA	PPGY	ITCH	528:531	Mutation rewiring degron network	0.1389
p.P528H	TCGA-BJ-A191	THCA	TCGA	PPGY	ITCH	528:531	Mutation altering degron motif	0.7694
p.P528H	DO40167	THCA	ICGC	PPGY	ITCH	528:531	Mutation altering degron motif	0.7694
p.Q426K	TCGA-BS-A0UV	UCEC	TCGA	QRQLLSRLQ	DEG_APCC_DBOX_1	430:438	Mutation rewiring degron network	0.2222
p.Q426K	DO42793	UCEC	ICGC	QRQLLSRLQ	DEG_APCC_DBOX_1	430:438	Mutation rewiring degron network	0.2222
p.N425I	TCGA-BT-A3PJ	BLCA	TCGA	QRQLLSRLQ	DEG_APCC_DBOX_1	430:438	Mutation rewiring degron network	0.1944
p.N425I	DO44097	BLCA	ICGC	QRQLLSRLQ	DEG_APCC_DBOX_1	430:438	Mutation rewiring degron network	0.1944
p.V520A	TCGA-D1-A2G0	UCEC	TCGA	PPGY	ITCH	528:531	Mutation rewiring degron network	0.1111
p.P441Q	TCGA-D3-A2JP	SKCM	TCGA	QRQLLSRLQ	DEG_APCC_DBOX_1	430:438	Mutation rewiring degron network	0.25
p.Q448H	TCGA-DA-A95Z	SKCM	TCGA	QRQLLSRLQ	DEG_APCC_DBOX_1	430:438	Mutation rewiring degron network	0.0556
p.R724Q	TCGA-GM-A2D9	BRCA	TCGA	PRHALKWIR	DEG_APCC_DBOX_1	723:731	Mutation altering degron motif	0.7329
p.N425S	TCGA-IB-7651	PAAD	TCGA	QRQLLSRLQ	DEG_APCC_DBOX_1	430:438	Mutation rewiring degron network	0.1944
p.N425S	DO46657	PAAD	ICGC	QRQLLSRLQ	DEG_APCC_DBOX_1	430:438	Mutation rewiring degron network	0.1944
p.Q136P	TCGA-L9-A443	LUAD	TCGA	VSTSS	DEG_SPOP_SBC_1	131:135	Mutation rewiring degron network	0.3056
p.Q136P	DO24285	LUAD	ICGC	VSTSS	DEG_SPOP_SBC_1	131:135	Mutation rewiring degron network	0.3056
p.I719N	TCGA-W3-A824	SKCM	TCGA	PRHALKWIR	DEG_APCC_DBOX_1	723:731	Mutation rewiring degron network	0.2222
p.C540F	DO228976	LICA	ICGC	PPGY	ITCH	528:531	Mutation rewiring degron network	0.0833
p.V423F	DO229026	LICA	ICGC	QRQLLSRLQ	DEG_APCC_DBOX_1	430:438	Mutation rewiring degron network	0.1389
p.P143Q	DO47407	SKCM	ICGC	VSTSS	DEG_SPOP_SBC_1	131:135	Mutation rewiring degron network	0.1111
p.E423K	DO229253	THCA	ICGC	QRQLLSRLQ	DEG_APCC_DBOX_1	430:438	Mutation rewiring degron network	0.1389
p.E127V	DO229275	THCA	ICGC	VSTSS	DEG_SPOP_SBC_1	131:135	Mutation rewiring degron network	0.2222
p.V126I	DO41235	UCEC	ICGC	VSTSS	DEG_SPOP_SBC_1	131:135	Mutation blocking ubiquitination signal	0.6389
p.Q134K	DO41235	UCEC	ICGC	VSTSS	DEG_SPOP_SBC_1	131:135	Mutation altering degron motif	0.6944
p.D538E	SIDM00845	Burkitt's Lymphoma	GDSC	PPGY	ITCH	528:531	Mutation rewiring degron network	0.1389
p.D538E	SIDM00461	Acute Myeloid Leukemia	GDSC	PPGY	ITCH	528:531	Mutation rewiring degron network	0.1389
p.D538E	SIDM00946	T-Lymphoblastic Leukemia	GDSC	PPGY	ITCH	528:531	Mutation rewiring degron network	0.1389
p.D538E	SIDM01519	Head and Neck Carcinoma	GDSC	PPGY	ITCH	528:531	Mutation rewiring degron network	0.1389
p.D538E	ACH-000786	Lymphoma	CCLE	PPGY	ITCH	528:531	Mutation rewiring degron network	0.1389
p.D538E	ACH-000992	Head and Neck Cancer	CCLE	PPGY	ITCH	528:531	Mutation rewiring degron network	0.1389
p.D538E	ACH-001067	Brain Cancer	CCLE	PPGY	ITCH	528:531	Mutation rewiring degron network	0.1389
p.D538E	DND-41	haematopoietic and lymphoid tissue	COSMIC	PPGY	ITCH	528:531	Mutation rewiring degron network	0.1389
p.D538E	OCI-AML5	haematopoietic and lymphoid tissue	COSMIC	PPGY	ITCH	528:531	Mutation rewiring degron network	0.1389
p.D538E	Daudi	haematopoietic and lymphoid tissue	COSMIC	PPGY	ITCH	528:531	Mutation rewiring degron network	0.1389
p.P732T	SIDM00886	B-Cell Non-Hodgkin's Lymphoma	GDSC	PRHALKWIR	DEG_APCC_DBOX_1	723:731	Mutation rewiring degron network	0.3056
p.P732T	DB	haematopoietic and lymphoid tissue	COSMIC	PRHALKWIR	DEG_APCC_DBOX_1	723:731	Mutation rewiring degron network	0.3056
p.R144I	SIDM00727	Non-Small Cell Lung Carcinoma	GDSC	VSTSS	DEG_SPOP_SBC_1	131:135	Mutation rewiring degron network	0.0833
p.R144I	NCI-H2342	lung	COSMIC	VSTSS	DEG_SPOP_SBC_1	131:135	Mutation rewiring degron network	0.0833
p.W729L	SIDM01611	Endometrial Carcinoma	GDSC	PRHALKWIR	DEG_APCC_DBOX_1	723:731	Mutation altering degron motif	0.5904
p.R436Q	SIDM01618	B-Lymphoblastic Leukemia	GDSC	QRQLLSRLQ	DEG_APCC_DBOX_1	430:438	Mutation altering degron motif	0.6218
p.R436Q	ACH-000942	Leukemia	CCLE	QRQLLSRLQ	DEG_APCC_DBOX_1	430:438	Mutation altering degron motif	0.6218
p.P726T	ACH-000334	Lymphoma	CCLE	PRHALKWIR	DEG_APCC_DBOX_1	723:731	Mutation altering degron motif	0.7031
p.P726T	DB	haematopoietic and lymphoid tissue	COSMIC	PRHALKWIR	DEG_APCC_DBOX_1	723:731	Mutation altering degron motif	0.7031
p.T521M	ACH-000811	Ovarian Cancer	CCLE	PPGY	ITCH	528:531	Mutation rewiring degron network	0.1389
p.W723L	ACH-000996	Endometrial/Uterine Cancer	CCLE	PRHALKWIR	DEG_APCC_DBOX_1	723:731	Mutation altering degron motif	0.7015
p.R725Q	ACH-001081	Colon/Colorectal Cancer	CCLE	PRHALKWIR	DEG_APCC_DBOX_1	723:731	Mutation altering degron motif	0.7329
p.R725Q	HCC2998	large intestine	COSMIC	PRHALKWIR	DEG_APCC_DBOX_1	723:731	Mutation altering degron motif	0.7329
p.P717L	ACH-002396	Bone Cancer	CCLE	PRHALKWIR	DEG_APCC_DBOX_1	723:731	Mutation rewiring degron network	0.1667
p.P717L	Sarc9371	bone	COSMIC	PRHALKWIR	DEG_APCC_DBOX_1	723:731	Mutation rewiring degron network	0.1667
p.L144W	PA-1	ovary	COSMIC	VSTSS	DEG_SPOP_SBC_1	131:135	Mutation rewiring degron network	0.0833
p.G445E	HOP-92	lung	COSMIC	QRQLLSRLQ	DEG_APCC_DBOX_1	430:438	Mutation rewiring degron network	0.1389
p.L442W	PA-1	ovary	COSMIC	QRQLLSRLQ	DEG_APCC_DBOX_1	430:438	Mutation rewiring degron network	0.2222
p.R435C	639-V	urinary tract	COSMIC	QRQLLSRLQ	DEG_APCC_DBOX_1	430:438	Mutation altering degron motif	0.8301
p.R433Q	HCC2998	large intestine	COSMIC	QRQLLSRLQ	DEG_APCC_DBOX_1	430:438	Mutation altering degron motif	0.7329
p.C531G	NCI-H2066	lung	COSMIC	PPGY	ITCH	528:531	Mutation altering degron motif	0.76
p.R444H	KOPN-8	haematopoietic and lymphoid tissue	COSMIC	QRQLLSRLQ	DEG_APCC_DBOX_1	430:438	Mutation rewiring degron network	0.1667
p.P434T	DB	haematopoietic and lymphoid tissue	COSMIC	QRQLLSRLQ	DEG_APCC_DBOX_1	430:438	Mutation altering degron motif	0.7031
p.E535K	NUGC-3	stomach	COSMIC	PPGY	ITCH	528:531	Mutation rewiring degron network	0.2222
p.A526S	Daudi	haematopoietic and lymphoid tissue	COSMIC	PPGY	ITCH	528:531	Mutation rewiring degron network	0.2778
p.A526S	DND-41	haematopoietic and lymphoid tissue	COSMIC	PPGY	ITCH	528:531	Mutation rewiring degron network	0.2778
p.L433W	PA-1	ovary	COSMIC	QRQLLSRLQ	DEG_APCC_DBOX_1	430:438	Mutation altering degron motif	0.5904
p.R444C	639-V	urinary tract	COSMIC	QRQLLSRLQ	DEG_APCC_DBOX_1	430:438	Mutation rewiring degron network	0.1667
p.R435H	KOPN-8	haematopoietic and lymphoid tissue	COSMIC	QRQLLSRLQ	DEG_APCC_DBOX_1	430:438	Mutation altering degron motif	0.8244
p.E527K	NUGC-3	stomach	COSMIC	PPGY	ITCH	528:531	Mutation blocking phosphorylation signal	0.75
p.P531S	H513	pleura	COSMIC	PPGY	ITCH	528:531	Mutation altering degron motif	0.6752
p.V144I	DG-75	haematopoietic and lymphoid tissue	COSMIC	VSTSS	DEG_SPOP_SBC_1	131:135	Mutation rewiring degron network	0.0833
p.D133N	NCI-H650	lung	COSMIC	VSTSS	DEG_SPOP_SBC_1	131:135	Mutation altering degron motif	0.6932
p.C523G	NCI-H2066	lung	COSMIC	PPGY	ITCH	528:531	Mutation rewiring degron network	0.1944

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ZC3H14

UniProt ID: Q6PJT7

Entrez ID: 79882

Protein name: Zinc finger CCCH domain-containing protein 14 (Mammalian suppressor of tau pathology-2) (MSUT-2) (Renal carcinoma antigen NY-REN-37)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ZC3H14 in