DegronMD

Uniprot ID: Q6PJT7

Source protein: Zinc finger CCCH domain-containing protein 14

Source gene: ZC3H14

Class: DEG_APCC_DBOX_1

Location: 430:438

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9945

ASA_SCORE: 100.8667

COIL: 0.3761

CONS_SCORE: 0.3467

DSS_SCORE: 0.5241

HELIX: 0.603

FCONS_SCORE: 1.0828

RIG_SCORE: 0.7888

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q432K	TCGA-A5-A0G2	UCEC	TCGA	QRQLLSRLQ	DEG_APCC_DBOX_1	0.5833
p.Q426K	TCGA-BS-A0UV	UCEC	TCGA	QRQLLSRLQ	DEG_APCC_DBOX_1	0.2222
p.Q426K	DO42793	UCEC	ICGC	QRQLLSRLQ	DEG_APCC_DBOX_1	0.2222
p.N425I	TCGA-BT-A3PJ	BLCA	TCGA	QRQLLSRLQ	DEG_APCC_DBOX_1	0.1944
p.N425I	DO44097	BLCA	ICGC	QRQLLSRLQ	DEG_APCC_DBOX_1	0.1944
p.P441Q	TCGA-D3-A2JP	SKCM	TCGA	QRQLLSRLQ	DEG_APCC_DBOX_1	0.25
p.Q448H	TCGA-DA-A95Z	SKCM	TCGA	QRQLLSRLQ	DEG_APCC_DBOX_1	0.0556
p.N425S	TCGA-IB-7651	PAAD	TCGA	QRQLLSRLQ	DEG_APCC_DBOX_1	0.1944
p.N425S	DO46657	PAAD	ICGC	QRQLLSRLQ	DEG_APCC_DBOX_1	0.1944
p.V423F	DO229026	LICA	ICGC	QRQLLSRLQ	DEG_APCC_DBOX_1	0.1389
p.E423K	DO229253	THCA	ICGC	QRQLLSRLQ	DEG_APCC_DBOX_1	0.1389
p.R436Q	SIDM01618	B-Lymphoblastic Leukemia	GDSC	QRQLLSRLQ	DEG_APCC_DBOX_1	0.6218
p.R436Q	ACH-000942	Leukemia	CCLE	QRQLLSRLQ	DEG_APCC_DBOX_1	0.6218
p.G445E	HOP-92	lung	COSMIC	QRQLLSRLQ	DEG_APCC_DBOX_1	0.1389
p.L442W	PA-1	ovary	COSMIC	QRQLLSRLQ	DEG_APCC_DBOX_1	0.2222
p.R435C	639-V	urinary_tract	COSMIC	QRQLLSRLQ	DEG_APCC_DBOX_1	0.8301
p.R433Q	HCC2998	large_intestine	COSMIC	QRQLLSRLQ	DEG_APCC_DBOX_1	0.7329
p.R444H	KOPN-8	haematopoietic_and_lymphoid_tissue	COSMIC	QRQLLSRLQ	DEG_APCC_DBOX_1	0.1667
p.P434T	DB	haematopoietic_and_lymphoid_tissue	COSMIC	QRQLLSRLQ	DEG_APCC_DBOX_1	0.7031
p.L433W	PA-1	ovary	COSMIC	QRQLLSRLQ	DEG_APCC_DBOX_1	0.5904
p.R444C	639-V	urinary_tract	COSMIC	QRQLLSRLQ	DEG_APCC_DBOX_1	0.1667
p.R435H	KOPN-8	haematopoietic_and_lymphoid_tissue	COSMIC	QRQLLSRLQ	DEG_APCC_DBOX_1	0.8244

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6PJT7	Zinc finger CCCH domain-containing protein 14	DEG_APCC_DBOX_1	430:438	QRQLLSRLQ	APC,CDC20,FZR1	0.9945	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons