DegronMD

Uniprot ID: Q6PJT7

Source protein: Zinc finger CCCH domain-containing protein 14

Source gene: ZC3H14

Class: DEG_APCC_DBOX_1

Location: 723:731

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9341

ASA_SCORE: 88.3444

COIL: 0.6242

CONS_SCORE: 0.4165

DSS_SCORE: 0.5129

HELIX: 0.1734

FCONS_SCORE: 1.081

RIG_SCORE: 0.799

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R731Q	TCGA-06-5416	GBM	TCGA	PRHALKWIR	DEG_APCC_DBOX_1	0.6218
p.R731Q	TCGA-BS-A0V4	UCEC	TCGA	PRHALKWIR	DEG_APCC_DBOX_1	0.6218
p.R731Q	SIDM00118	Colorectal Carcinoma	GDSC	PRHALKWIR	DEG_APCC_DBOX_1	0.6218
p.R731Q	HCC2998	large_intestine	COSMIC	PRHALKWIR	DEG_APCC_DBOX_1	0.6218
p.F714L	TCGA-55-7726	LUAD	TCGA	PRHALKWIR	DEG_APCC_DBOX_1	0.0833
p.R724Q	TCGA-GM-A2D9	BRCA	TCGA	PRHALKWIR	DEG_APCC_DBOX_1	0.7329
p.I719N	TCGA-W3-A824	SKCM	TCGA	PRHALKWIR	DEG_APCC_DBOX_1	0.2222
p.P732T	SIDM00886	B-Cell Non-Hodgkin's Lymphoma	GDSC	PRHALKWIR	DEG_APCC_DBOX_1	0.3056
p.P732T	DB	haematopoietic_and_lymphoid_tissue	COSMIC	PRHALKWIR	DEG_APCC_DBOX_1	0.3056
p.W729L	SIDM01611	Endometrial Carcinoma	GDSC	PRHALKWIR	DEG_APCC_DBOX_1	0.5904
p.P726T	ACH-000334	Lymphoma	CCLE	PRHALKWIR	DEG_APCC_DBOX_1	0.7031
p.P726T	DB	haematopoietic_and_lymphoid_tissue	COSMIC	PRHALKWIR	DEG_APCC_DBOX_1	0.7031
p.W723L	ACH-000996	Endometrial/Uterine Cancer	CCLE	PRHALKWIR	DEG_APCC_DBOX_1	0.7015
p.R725Q	ACH-001081	Colon/Colorectal Cancer	CCLE	PRHALKWIR	DEG_APCC_DBOX_1	0.7329
p.R725Q	HCC2998	large_intestine	COSMIC	PRHALKWIR	DEG_APCC_DBOX_1	0.7329
p.P717L	ACH-002396	Bone Cancer	CCLE	PRHALKWIR	DEG_APCC_DBOX_1	0.1667
p.P717L	Sarc9371	bone	COSMIC	PRHALKWIR	DEG_APCC_DBOX_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6PJT7	Zinc finger CCCH domain-containing protein 14	DEG_APCC_DBOX_1	723:731	PRHALKWIR	APC,CDC20,FZR1	0.9341	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons