DegronMD

Uniprot ID: Q9NZM3

Source protein: Intersectin-2

Source gene: ITSN2

Class: DEG_SPOP_SBC_1

Location: 181:185

E3 ligase: SPOP

DEGRON score: 0.983

ASA_SCORE: 78.92

COIL: 0.9182

CONS_SCORE: 0.2654

DSS_SCORE: 0.344

HELIX: 0.034

FCONS_SCORE: 1.0091

RIG_SCORE: 0.6841

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G190E	TCGA-2L-AAQJ	PAAD	TCGA	PYSSS	DEG_SPOP_SBC_1	0.1944
p.G190E	DO218949	PAAD	ICGC	PYSSS	DEG_SPOP_SBC_1	0.1944
p.L195V	TCGA-86-6851	LUAD	TCGA	PYSSS	DEG_SPOP_SBC_1	0.0556
p.L195V	DO23798	LUAD	ICGC	PYSSS	DEG_SPOP_SBC_1	0.0556
p.P188S	DO48223	ESCA	ICGC	PYSSS	DEG_SPOP_SBC_1	0.25
p.A172T	DO233210	GACA	ICGC	PYSSS	DEG_SPOP_SBC_1	0.0833
p.T171N	DO229036	LICA	ICGC	PYSSS	DEG_SPOP_SBC_1	0.0556
p.H189N	DO231026	LUSC	ICGC	PYSSS	DEG_SPOP_SBC_1	0.2222
p.P181S	DO220908	MELA	ICGC	PYSSS	DEG_SPOP_SBC_1	0.6752
p.P179S	SIDM00845	Burkitt's Lymphoma	GDSC	PYSSS	DEG_SPOP_SBC_1	0.2778
p.P179S	SIDM01519	Head and Neck Carcinoma	GDSC	PYSSS	DEG_SPOP_SBC_1	0.2778
p.S185L	SIDM00694	Other Solid Cancers	GDSC	PYSSS	DEG_SPOP_SBC_1	0.7667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A7KAX9	Rho GTPase-activating protein 32	DEG_SPOP_SBC_1	1652:1656	PYSSS	SPOP	0.9915	More...
A8MQ03	Cysteine-rich tail protein 1	DEG_SPOP_SBC_1	90:94	PYSSS	SPOP	0.6254	More...
O43166	Signal-induced proliferation-associated 1-like protein 1	DEG_SPOP_SBC_1	1726:1730	PYSSS	SPOP	0.9278	More...
P54259	Atrophin-1	DEG_SPOP_SBC_1	374:378	PYSSS	SPOP	0.9833	More...
Q14004	Cyclin-dependent kinase 13	DEG_SPOP_SBC_1	386:390	PYSSS	SPOP	0.9958	More...
Q92922	SWI/SNF complex subunit SMARCC1	DEG_SPOP_SBC_1	208:212	PYSSS	SPOP	0.9771	More...
Q9BWW4	Single-stranded DNA-binding protein 3	DEG_SPOP_SBC_1	257:261	PYSSS	SPOP	0.685	More...
Q9NZM3	Intersectin-2	DEG_SPOP_SBC_1	181:185	PYSSS	SPOP	0.983	More...
Q9UL40	Zinc finger protein 346	DEG_SPOP_SBC_1	19:23	PYSSS	SPOP	0.9528	More...
Q9UQB3	Catenin delta-2	DEG_SPOP_SBC_1	1050:1054	PYSSS	SPOP	0.7199	More...
Q9Y5X4	Photoreceptor-specific nuclear receptor	DEG_SPOP_SBC_1	208:212	PYSSS	SPOP	0.9744	More...
Q8WYQ9	Zinc finger CCHC domain-containing protein 14	DEG_SPOP_SBC_1	853:857	PYSSS	SPOP	0.6609	More...
Q53SF7	Cordon-bleu protein-like 1	DEG_SPOP_SBC_1	979:983	PYSSS	SPOP	0.9833	More...
Q9BWG4	Single-stranded DNA-binding protein 4	DEG_SPOP_SBC_1	252:256	PYSSS	SPOP	0.9926	More...
Q9BZE3	BarH-like 1 homeobox protein	DEG_SPOP_SBC_1	113:117	PYSSS	SPOP	0.8569	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons