DegronMD - Q9UQB3(CTNND2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P139Q	TCGA-33-4583	LUSC	TCGA	DYSTGE	DEG_Kelch_Keap1_1	141:146	Mutation rewiring degron network	0.2778
p.Q132K	TCGA-50-5933	LUAD	TCGA	DYSTGE	DEG_Kelch_Keap1_1	141:146	Mutation rewiring degron network	0.0833
p.R1063C	TCGA-62-A46O	LUAD	TCGA	PYSSS	DEG_SPOP_SBC_1	1050:1054	Mutation rewiring degron network	0.0833
p.R1063C	TCGA-AX-A1CE	UCEC	TCGA	PYSSS	DEG_SPOP_SBC_1	1050:1054	Mutation rewiring degron network	0.0833
p.R1063C	TCGA-BR-6452	STAD	TCGA	PYSSS	DEG_SPOP_SBC_1	1050:1054	Mutation rewiring degron network	0.0833
p.R1063C	TCGA-EA-A3HU	CESC	TCGA	PYSSS	DEG_SPOP_SBC_1	1050:1054	Mutation rewiring degron network	0.0833
p.R1063C	SIDM00958	Chronic Myelogenous Leukemia	GDSC	PYSSS	DEG_SPOP_SBC_1	1050:1054	Mutation rewiring degron network	0.0833
p.R1063C	ACH-000920	Leukemia	CCLE	PYSSS	DEG_SPOP_SBC_1	1050:1054	Mutation rewiring degron network	0.0833
p.R1063C	CML-T1	haematopoietic and lymphoid tissue	COSMIC	PYSSS	DEG_SPOP_SBC_1	1050:1054	Mutation rewiring degron network	0.0833
p.L150M	TCGA-66-2782	LUSC	TCGA	DYSTGE	DEG_Kelch_Keap1_1	141:146	Mutation rewiring degron network	0.2222
p.L150M	DO26680	LUSC	ICGC	DYSTGE	DEG_Kelch_Keap1_1	141:146	Mutation rewiring degron network	0.2222
p.S1054Y	TCGA-85-A50Z	LUSC	TCGA	PYSSS	DEG_SPOP_SBC_1	1050:1054	Mutation altering degron motif	0.712
p.L151F	TCGA-A5-A0G1	UCEC	TCGA	DYSTGE	DEG_Kelch_Keap1_1	141:146	Mutation rewiring degron network	0.1944
p.L151F	DO42472	UCEC	ICGC	DYSTGE	DEG_Kelch_Keap1_1	141:146	Mutation rewiring degron network	0.1944
p.R1055C	TCGA-A5-A0G2	UCEC	TCGA	PYSSS	DEG_SPOP_SBC_1	1050:1054	Mutation rewiring degron network	0.3056
p.R1047Q	TCGA-B1-A654	KIRP	TCGA	VASSS	DEG_SPOP_SBC_1	1037:1041	Mutation rewiring degron network	0.1667
p.R1047Q	TCGA-B1-A654	KIRP	TCGA	PYSSS	DEG_SPOP_SBC_1	1050:1054	Mutation rewiring degron network	0.25
p.R1047Q	TCGA-OR-A5JE	ACC	TCGA	VASSS	DEG_SPOP_SBC_1	1037:1041	Mutation rewiring degron network	0.1667
p.R1047Q	TCGA-OR-A5JE	ACC	TCGA	PYSSS	DEG_SPOP_SBC_1	1050:1054	Mutation rewiring degron network	0.25
p.T1056M	TCGA-CD-5798	STAD	TCGA	PYSSS	DEG_SPOP_SBC_1	1050:1054	Mutation rewiring degron network	0.2778
p.I1059M	TCGA-CV-5978	HNSC	TCGA	PYSSS	DEG_SPOP_SBC_1	1050:1054	Mutation rewiring degron network	0.1944
p.S152F	TCGA-D3-A8GI	SKCM	TCGA	DYSTGE	DEG_Kelch_Keap1_1	141:146	Mutation rewiring degron network	0.1667
p.S152F	DO50284	SKCM	ICGC	DYSTGE	DEG_Kelch_Keap1_1	141:146	Mutation rewiring degron network	0.1667
p.Q153H	TCGA-DU-7294	LGG	TCGA	DYSTGE	DEG_Kelch_Keap1_1	141:146	Mutation rewiring degron network	0.1389
p.Q153H	TCGA-XF-AAMZ	BLCA	TCGA	DYSTGE	DEG_Kelch_Keap1_1	141:146	Mutation rewiring degron network	0.1389
p.Q153H	DO219051	BLCA	ICGC	DYSTGE	DEG_Kelch_Keap1_1	141:146	Mutation rewiring degron network	0.1389
p.Q153H	DO22333	LGG	ICGC	DYSTGE	DEG_Kelch_Keap1_1	141:146	Mutation rewiring degron network	0.1389
p.P1050L	TCGA-EB-A97M	SKCM	TCGA	PYSSS	DEG_SPOP_SBC_1	1050:1054	Mutation altering degron motif	0.7582
p.D1029N	TCGA-EE-A29M	SKCM	TCGA	VASSS	DEG_SPOP_SBC_1	1037:1041	Mutation rewiring degron network	0.1111
p.S1058F	TCGA-ER-A19L	SKCM	TCGA	PYSSS	DEG_SPOP_SBC_1	1050:1054	Mutation rewiring degron network	0.2222
p.S1039L	TCGA-FW-A3R5	SKCM	TCGA	VASSS	DEG_SPOP_SBC_1	1037:1041	Mutation altering degron motif	0.7667
p.S1039L	SIDM01950	Colorectal Carcinoma	GDSC	VASSS	DEG_SPOP_SBC_1	1037:1041	Mutation altering degron motif	0.7667
p.Q153K	TCGA-FY-A3BL	THCA	TCGA	DYSTGE	DEG_Kelch_Keap1_1	141:146	Mutation rewiring degron network	0.1389
p.Q153K	DO40190	THCA	ICGC	DYSTGE	DEG_Kelch_Keap1_1	141:146	Mutation rewiring degron network	0.1389
p.V1064M	TCGA-G4-6627	COAD	TCGA	PYSSS	DEG_SPOP_SBC_1	1050:1054	Mutation rewiring degron network	0.0556
p.V1064M	SIDM01004	Chronic Myelogenous Leukemia	GDSC	PYSSS	DEG_SPOP_SBC_1	1050:1054	Mutation rewiring degron network	0.0556
p.V1064M	SIDM00352	Ovarian Carcinoma	GDSC	PYSSS	DEG_SPOP_SBC_1	1050:1054	Mutation rewiring degron network	0.0556
p.V1064M	KCL-22	haematopoietic and lymphoid tissue	COSMIC	PYSSS	DEG_SPOP_SBC_1	1050:1054	Mutation rewiring degron network	0.0556
p.R134H	DO51634	CESC	ICGC	DYSTGE	DEG_Kelch_Keap1_1	141:146	Mutation rewiring degron network	0.1389
p.R134H	DO27184	LUSC	ICGC	DYSTGE	DEG_Kelch_Keap1_1	141:146	Mutation rewiring degron network	0.1389
p.R134H	DO37146	READ	ICGC	DYSTGE	DEG_Kelch_Keap1_1	141:146	Mutation rewiring degron network	0.1389
p.R134H	DO48173	UCEC	ICGC	DYSTGE	DEG_Kelch_Keap1_1	141:146	Mutation rewiring degron network	0.1389
p.Q142H	DO9002	COAD	ICGC	DYSTGE	DEG_Kelch_Keap1_1	141:146	Mutation altering degron motif	0.7582
p.G140S	DO7781	COAD	ICGC	DYSTGE	DEG_Kelch_Keap1_1	141:146	Mutation rewiring degron network	0.3056
p.G140S	DO7804	COAD	ICGC	DYSTGE	DEG_Kelch_Keap1_1	141:146	Mutation rewiring degron network	0.3056
p.G140S	SIMA	autonomic ganglia	COSMIC	DYSTGE	DEG_Kelch_Keap1_1	141:146	Mutation rewiring degron network	0.3056
p.A146V	DO9756	COAD	ICGC	DYSTGE	DEG_Kelch_Keap1_1	141:146	Mutation altering degron motif	0.6936
p.A146V	DO219138	LUSC	ICGC	DYSTGE	DEG_Kelch_Keap1_1	141:146	Mutation altering degron motif	0.6936
p.A146V	DO27835	MALY	ICGC	DYSTGE	DEG_Kelch_Keap1_1	141:146	Mutation altering degron motif	0.6936
p.G1061E	DO11854	GBM	ICGC	PYSSS	DEG_SPOP_SBC_1	1050:1054	Mutation rewiring degron network	0.1389
p.Q142E	DO49067	HNSC	ICGC	DYSTGE	DEG_Kelch_Keap1_1	141:146	Mutation altering degron motif	0.6744
p.Q150H	DO14654	HNSC	ICGC	DYSTGE	DEG_Kelch_Keap1_1	141:146	Mutation rewiring degron network	0.2222
p.H139Q	DO14173	HNSC	ICGC	DYSTGE	DEG_Kelch_Keap1_1	141:146	Mutation rewiring degron network	0.2778
p.H1042Q	DO228948	LICA	ICGC	VASSS	DEG_SPOP_SBC_1	1037:1041	Mutation blocking phosphorylation signal	0.75
p.H1042Q	DO228948	LICA	ICGC	PYSSS	DEG_SPOP_SBC_1	1050:1054	Mutation blocking phosphorylation signal	0.5556
p.A152V	DO45402	LUAD	ICGC	DYSTGE	DEG_Kelch_Keap1_1	141:146	Mutation rewiring degron network	0.1667
p.G136C	DO23604	LUAD	ICGC	DYSTGE	DEG_Kelch_Keap1_1	141:146	Mutation rewiring degron network	0.1944
p.Y154C	DO23597	LUAD	ICGC	DYSTGE	DEG_Kelch_Keap1_1	141:146	Mutation rewiring degron network	0.1111
p.G136V	DO26052	LUAD	ICGC	DYSTGE	DEG_Kelch_Keap1_1	141:146	Mutation rewiring degron network	0.1944
p.T1056K	DO231043	LUSC	ICGC	PYSSS	DEG_SPOP_SBC_1	1050:1054	Mutation rewiring degron network	0.2778
p.A145T	DO45494	LUSC	ICGC	DYSTGE	DEG_Kelch_Keap1_1	141:146	Mutation altering degron motif	0.7139
p.A147S	DO45442	LUSC	ICGC	DYSTGE	DEG_Kelch_Keap1_1	141:146	Mutation rewiring degron network	0.3056
p.T148A	DO36556	READ	ICGC	DYSTGE	DEG_Kelch_Keap1_1	141:146	Mutation rewiring degron network	0.2778
p.G140D	DO218863	SKCA	ICGC	DYSTGE	DEG_Kelch_Keap1_1	141:146	Mutation rewiring degron network	0.3056
p.A147V	DO223907	SKCM	ICGC	DYSTGE	DEG_Kelch_Keap1_1	141:146	Mutation rewiring degron network	0.3056
p.A156T	DO47757	STAD	ICGC	DYSTGE	DEG_Kelch_Keap1_1	141:146	Mutation rewiring degron network	0.0556
p.Q153L	DO229221	THCA	ICGC	DYSTGE	DEG_Kelch_Keap1_1	141:146	Mutation rewiring degron network	0.1389
p.R134C	DO42201	UCEC	ICGC	DYSTGE	DEG_Kelch_Keap1_1	141:146	Mutation rewiring degron network	0.1389
p.R1063H	SIDM02017	Colorectal Carcinoma	GDSC	PYSSS	DEG_SPOP_SBC_1	1050:1054	Mutation rewiring degron network	0.0833
p.S1060F	SIDM00545	Melanoma	GDSC	PYSSS	DEG_SPOP_SBC_1	1050:1054	Mutation blocking phosphorylation signal	0.6111
p.S1060F	ACH-000987	Skin Cancer	CCLE	PYSSS	DEG_SPOP_SBC_1	1050:1054	Mutation blocking phosphorylation signal	0.6111
p.S1060F	Mewo	skin	COSMIC	PYSSS	DEG_SPOP_SBC_1	1050:1054	Mutation blocking phosphorylation signal	0.6111
p.V1062A	SIDM00383	Gastric Carcinoma	GDSC	PYSSS	DEG_SPOP_SBC_1	1050:1054	Mutation rewiring degron network	0.1111
p.V1062A	ACH-002198	Gastric Cancer	CCLE	PYSSS	DEG_SPOP_SBC_1	1050:1054	Mutation rewiring degron network	0.1111
p.V1062A	SCH	stomach	COSMIC	PYSSS	DEG_SPOP_SBC_1	1050:1054	Mutation rewiring degron network	0.1111
p.L150R	SIDM00302	Other Solid Cancers	GDSC	DYSTGE	DEG_Kelch_Keap1_1	141:146	Mutation rewiring degron network	0.2222
p.L150R	ACH-002149	Ovarian Cancer	CCLE	DYSTGE	DEG_Kelch_Keap1_1	141:146	Mutation rewiring degron network	0.2222
p.L150R	KGN	ovary	COSMIC	DYSTGE	DEG_Kelch_Keap1_1	141:146	Mutation rewiring degron network	0.2222
p.A1041P	KYAE-1	oesophagus	COSMIC	VASSS	DEG_SPOP_SBC_1	1037:1041	Mutation altering degron motif	0.7503
p.A1041P	WIL2-NS	haematopoietic and lymphoid tissue	COSMIC	VASSS	DEG_SPOP_SBC_1	1037:1041	Mutation altering degron motif	0.7503
p.G1028E	SK-MEL-3	skin	COSMIC	VASSS	DEG_SPOP_SBC_1	1037:1041	Mutation substituting flanking lysine	0.1944
p.A146T	MDA-MB-157	breast	COSMIC	DYSTGE	DEG_Kelch_Keap1_1	141:146	Mutation altering degron motif	0.7139
p.S155F	Mewo	skin	COSMIC	DYSTGE	DEG_Kelch_Keap1_1	141:146	Mutation rewiring degron network	0.0833
p.P131L	NCI-H520	lung	COSMIC	DYSTGE	DEG_Kelch_Keap1_1	141:146	Mutation rewiring degron network	0.0556
p.N143K	NCI-H2066	lung	COSMIC	DYSTGE	DEG_Kelch_Keap1_1	141:146	Mutation altering degron motif	0.6918

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CTNND2

UniProt ID: Q9UQB3

Entrez ID: 1501

Protein name: Catenin delta-2 (Delta-catenin) (GT24) (Neural plakophilin-related ARM-repeat protein) (NPRAP) (Neurojungin)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CTNND2 in