DegronMD

Uniprot ID: Q9UQB3

Source protein: Catenin delta-2

Source gene: CTNND2

Class: DEG_SPOP_SBC_1

Location: 1050:1054

E3 ligase: SPOP

DEGRON score: 0.7199

ASA_SCORE: 88.22

COIL: 0.907

CONS_SCORE: 0.335

DSS_SCORE: 0.6129

HELIX: 0.0636

FCONS_SCORE: 0.9177

RIG_SCORE: 0.6083

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R1063C	TCGA-62-A46O	LUAD	TCGA	PYSSS	DEG_SPOP_SBC_1	0.0833
p.R1063C	TCGA-AX-A1CE	UCEC	TCGA	PYSSS	DEG_SPOP_SBC_1	0.0833
p.R1063C	TCGA-BR-6452	STAD	TCGA	PYSSS	DEG_SPOP_SBC_1	0.0833
p.R1063C	TCGA-EA-A3HU	CESC	TCGA	PYSSS	DEG_SPOP_SBC_1	0.0833
p.R1063C	SIDM00958	Chronic Myelogenous Leukemia	GDSC	PYSSS	DEG_SPOP_SBC_1	0.0833
p.R1063C	ACH-000920	Leukemia	CCLE	PYSSS	DEG_SPOP_SBC_1	0.0833
p.R1063C	CML-T1	haematopoietic_and_lymphoid_tissue	COSMIC	PYSSS	DEG_SPOP_SBC_1	0.0833
p.S1054Y	TCGA-85-A50Z	LUSC	TCGA	PYSSS	DEG_SPOP_SBC_1	0.712
p.R1055C	TCGA-A5-A0G2	UCEC	TCGA	PYSSS	DEG_SPOP_SBC_1	0.3056
p.R1047Q	TCGA-B1-A654	KIRP	TCGA	PYSSS	DEG_SPOP_SBC_1	0.25
p.R1047Q	TCGA-OR-A5JE	ACC	TCGA	PYSSS	DEG_SPOP_SBC_1	0.25
p.T1056M	TCGA-CD-5798	STAD	TCGA	PYSSS	DEG_SPOP_SBC_1	0.2778
p.I1059M	TCGA-CV-5978	HNSC	TCGA	PYSSS	DEG_SPOP_SBC_1	0.1944
p.P1050L	TCGA-EB-A97M	SKCM	TCGA	PYSSS	DEG_SPOP_SBC_1	0.7582
p.S1058F	TCGA-ER-A19L	SKCM	TCGA	PYSSS	DEG_SPOP_SBC_1	0.2222
p.V1064M	TCGA-G4-6627	COAD	TCGA	PYSSS	DEG_SPOP_SBC_1	0.0556
p.V1064M	SIDM01004	Chronic Myelogenous Leukemia	GDSC	PYSSS	DEG_SPOP_SBC_1	0.0556
p.V1064M	SIDM00352	Ovarian Carcinoma	GDSC	PYSSS	DEG_SPOP_SBC_1	0.0556
p.V1064M	KCL-22	haematopoietic_and_lymphoid_tissue	COSMIC	PYSSS	DEG_SPOP_SBC_1	0.0556
p.G1061E	DO11854	GBM	ICGC	PYSSS	DEG_SPOP_SBC_1	0.1389
p.H1042Q	DO228948	LICA	ICGC	PYSSS	DEG_SPOP_SBC_1	0.5556
p.T1056K	DO231043	LUSC	ICGC	PYSSS	DEG_SPOP_SBC_1	0.2778
p.R1063H	SIDM02017	Colorectal Carcinoma	GDSC	PYSSS	DEG_SPOP_SBC_1	0.0833
p.S1060F	SIDM00545	Melanoma	GDSC	PYSSS	DEG_SPOP_SBC_1	0.6111
p.S1060F	ACH-000987	Skin Cancer	CCLE	PYSSS	DEG_SPOP_SBC_1	0.6111
p.S1060F	Mewo	skin	COSMIC	PYSSS	DEG_SPOP_SBC_1	0.6111
p.V1062A	SIDM00383	Gastric Carcinoma	GDSC	PYSSS	DEG_SPOP_SBC_1	0.1111
p.V1062A	ACH-002198	Gastric Cancer	CCLE	PYSSS	DEG_SPOP_SBC_1	0.1111
p.V1062A	SCH	stomach	COSMIC	PYSSS	DEG_SPOP_SBC_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A7KAX9	Rho GTPase-activating protein 32	DEG_SPOP_SBC_1	1652:1656	PYSSS	SPOP	0.9915	More...
A8MQ03	Cysteine-rich tail protein 1	DEG_SPOP_SBC_1	90:94	PYSSS	SPOP	0.6254	More...
O43166	Signal-induced proliferation-associated 1-like protein 1	DEG_SPOP_SBC_1	1726:1730	PYSSS	SPOP	0.9278	More...
P54259	Atrophin-1	DEG_SPOP_SBC_1	374:378	PYSSS	SPOP	0.9833	More...
Q14004	Cyclin-dependent kinase 13	DEG_SPOP_SBC_1	386:390	PYSSS	SPOP	0.9958	More...
Q92922	SWI/SNF complex subunit SMARCC1	DEG_SPOP_SBC_1	208:212	PYSSS	SPOP	0.9771	More...
Q9BWW4	Single-stranded DNA-binding protein 3	DEG_SPOP_SBC_1	257:261	PYSSS	SPOP	0.685	More...
Q9NZM3	Intersectin-2	DEG_SPOP_SBC_1	181:185	PYSSS	SPOP	0.983	More...
Q9UL40	Zinc finger protein 346	DEG_SPOP_SBC_1	19:23	PYSSS	SPOP	0.9528	More...
Q9UQB3	Catenin delta-2	DEG_SPOP_SBC_1	1050:1054	PYSSS	SPOP	0.7199	More...
Q9Y5X4	Photoreceptor-specific nuclear receptor	DEG_SPOP_SBC_1	208:212	PYSSS	SPOP	0.9744	More...
Q8WYQ9	Zinc finger CCHC domain-containing protein 14	DEG_SPOP_SBC_1	853:857	PYSSS	SPOP	0.6609	More...
Q53SF7	Cordon-bleu protein-like 1	DEG_SPOP_SBC_1	979:983	PYSSS	SPOP	0.9833	More...
Q9BWG4	Single-stranded DNA-binding protein 4	DEG_SPOP_SBC_1	252:256	PYSSS	SPOP	0.9926	More...
Q9BZE3	BarH-like 1 homeobox protein	DEG_SPOP_SBC_1	113:117	PYSSS	SPOP	0.8569	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PYSSS

Degron related mutations and impact score

Drug responses associated with CTNND2 mutations

All proteins holding degron of PYSSS