DegronMD - Q8WYQ9(ZCCHC14)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R17L	TCGA-50-7109	LUAD	TCGA	LRQELTQIQ	DEG_APCC_DBOX_1	16:24	Mutation altering degron motif	0.8428
p.R17L	DO24487	LUAD	ICGC	LRQELTQIQ	DEG_APCC_DBOX_1	16:24	Mutation altering degron motif	0.8428
p.V62I	TCGA-A5-A0GB	UCEC	TCGA	ITPRTE	DEG_SCF_FBW7_2	54:59	Mutation rewiring degron network	0.25
p.V62I	DO41434	UCEC	ICGC	ITPRTE	DEG_SCF_FBW7_2	54:59	Mutation rewiring degron network	0.25
p.V616M	TCGA-AA-3672	COAD	TCGA	VETST	DEG_SPOP_SBC_1	616:620	Mutation altering degron motif	0.7208
p.V616M	DO9010	COAD	ICGC	VETST	DEG_SPOP_SBC_1	616:620	Mutation altering degron motif	0.7208
p.V616M	DO35083	PACA	ICGC	VETST	DEG_SPOP_SBC_1	616:620	Mutation altering degron motif	0.7208
p.V616M	SIDM00282	Colorectal Carcinoma	GDSC	VETST	DEG_SPOP_SBC_1	616:620	Mutation altering degron motif	0.7208
p.V616M	ACH-000998	Colon/Colorectal Cancer	CCLE	VETST	DEG_SPOP_SBC_1	616:620	Mutation altering degron motif	0.7208
p.V616M	CW-2	large intestine	COSMIC	VETST	DEG_SPOP_SBC_1	616:620	Mutation altering degron motif	0.7208
p.S855I	TCGA-AP-A059	UCEC	TCGA	PYSSS	DEG_SPOP_SBC_1	853:857	Mutation altering degron motif	0.7341
p.S855I	DO41361	UCEC	ICGC	PYSSS	DEG_SPOP_SBC_1	853:857	Mutation altering degron motif	0.7341
p.T625M	TCGA-AX-A2HA	UCEC	TCGA	VETST	DEG_SPOP_SBC_1	616:620	Mutation rewiring degron network	0.1944
p.T625M	DO233903	GACA	ICGC	VETST	DEG_SPOP_SBC_1	616:620	Mutation rewiring degron network	0.1944
p.T625M	DO42504	UCEC	ICGC	VETST	DEG_SPOP_SBC_1	616:620	Mutation rewiring degron network	0.1944
p.A609V	TCGA-B5-A1MW	UCEC	TCGA	VETST	DEG_SPOP_SBC_1	616:620	Mutation rewiring degron network	0.1389
p.A609V	DO42913	UCEC	ICGC	VETST	DEG_SPOP_SBC_1	616:620	Mutation rewiring degron network	0.1389
p.V65I	TCGA-CD-A4MI	STAD	TCGA	ITPRTE	DEG_SCF_FBW7_2	54:59	Mutation rewiring degron network	0.1667
p.V65I	DO47717	STAD	ICGC	ITPRTE	DEG_SCF_FBW7_2	54:59	Mutation rewiring degron network	0.1667
p.R57T	TCGA-CZ-5467	KIRC	TCGA	ITPRTE	DEG_SCF_FBW7_2	54:59	Mutation altering degron motif	0.6765
p.R57T	DO16256	KIRC	ICGC	ITPRTE	DEG_SCF_FBW7_2	54:59	Mutation altering degron motif	0.6765
p.A718T	TCGA-D1-A103	UCEC	TCGA	APSSS	DEG_SPOP_SBC_1	728:732	Mutation rewiring degron network	0.0556
p.A718T	DO42312	UCEC	ICGC	APSSS	DEG_SPOP_SBC_1	728:732	Mutation rewiring degron network	0.0556
p.F465S	TCGA-D1-A17Q	UCEC	TCGA	RPTAQVLPV	DEG_SIAH_1	471:479	Mutation rewiring degron network	0.1667
p.F465S	DO41903	UCEC	ICGC	RPTAQVLPV	DEG_SIAH_1	471:479	Mutation rewiring degron network	0.1667
p.G624E	TCGA-DF-A2KN	UCEC	TCGA	VETST	DEG_SPOP_SBC_1	616:620	Mutation rewiring degron network	0.2222
p.G624E	DO223282	UCEC	ICGC	VETST	DEG_SPOP_SBC_1	616:620	Mutation rewiring degron network	0.2222
p.V616A	TCGA-DI-A1BU	UCEC	TCGA	VETST	DEG_SPOP_SBC_1	616:620	Mutation altering degron motif	0.5825
p.V616A	DO42023	UCEC	ICGC	VETST	DEG_SPOP_SBC_1	616:620	Mutation altering degron motif	0.5825
p.S856C	TCGA-EE-A29S	SKCM	TCGA	PYSSS	DEG_SPOP_SBC_1	853:857	Mutation altering degron motif	0.7541
p.S856C	DO37936	SKCM	ICGC	PYSSS	DEG_SPOP_SBC_1	853:857	Mutation altering degron motif	0.7541
p.P860L	TCGA-EE-A2MD	SKCM	TCGA	PYSSS	DEG_SPOP_SBC_1	853:857	Mutation rewiring degron network	0.25
p.P860L	DO222434	MELA	ICGC	PYSSS	DEG_SPOP_SBC_1	853:857	Mutation rewiring degron network	0.25
p.P860L	DO37851	SKCM	ICGC	PYSSS	DEG_SPOP_SBC_1	853:857	Mutation rewiring degron network	0.25
p.K607N	TCGA-ER-A19F	SKCM	TCGA	VETST	DEG_SPOP_SBC_1	616:620	Mutation substituting flanking lysine	0.1944
p.K607N	DO37679	SKCM	ICGC	VETST	DEG_SPOP_SBC_1	616:620	Mutation substituting flanking lysine	0.1944
p.A622T	TCGA-F4-6703	COAD	TCGA	VETST	DEG_SPOP_SBC_1	616:620	Mutation rewiring degron network	0.2778
p.A622T	DO9908	COAD	ICGC	VETST	DEG_SPOP_SBC_1	616:620	Mutation rewiring degron network	0.2778
p.P729R	TCGA-FR-A7U9	SKCM	TCGA	APSSS	DEG_SPOP_SBC_1	728:732	Mutation altering degron motif	0.6401
p.P729R	DO48546	SKCM	ICGC	APSSS	DEG_SPOP_SBC_1	728:732	Mutation altering degron motif	0.6401
p.S730C	TCGA-OR-A5KB	ACC	TCGA	APSSS	DEG_SPOP_SBC_1	728:732	Mutation altering degron motif	0.7541
p.A728S	DO52016	CLLE	ICGC	APSSS	DEG_SPOP_SBC_1	728:732	Mutation altering degron motif	0.7588
p.T722M	DO230311	COCA	ICGC	APSSS	DEG_SPOP_SBC_1	728:732	Mutation rewiring degron network	0.1667
p.Y854S	DO234261	ESAD	ICGC	PYSSS	DEG_SPOP_SBC_1	853:857	Mutation altering degron motif	0.6009
p.I54V	DO229346	LAML	ICGC	ITPRTE	DEG_SCF_FBW7_2	54:59	Mutation altering degron motif	0.5965
p.I54V	DO52365	LUSC	ICGC	ITPRTE	DEG_SCF_FBW7_2	54:59	Mutation altering degron motif	0.5965
p.G31R	DO229493	LAML	ICGC	LRQELTQIQ	DEG_APCC_DBOX_1	16:24	Mutation rewiring degron network	0.1389
p.S627R	DO228948	LICA	ICGC	VETST	DEG_SPOP_SBC_1	616:620	Mutation rewiring degron network	0.1389
p.S627N	DO228967	LICA	ICGC	VETST	DEG_SPOP_SBC_1	616:620	Mutation rewiring degron network	0.1389
p.H52N	DO229015	LICA	ICGC	ITPRTE	DEG_SCF_FBW7_2	54:59	Mutation rewiring degron network	0.2778
p.P733Q	DO229026	LICA	ICGC	APSSS	DEG_SPOP_SBC_1	728:732	Mutation rewiring degron network	0.3056
p.S732R	DO229031	LICA	ICGC	APSSS	DEG_SPOP_SBC_1	728:732	Mutation altering degron motif	0.7427
p.Q24L	DO23158	LINC	ICGC	LRQELTQIQ	DEG_APCC_DBOX_1	16:24	Mutation altering degron motif	0.6654
p.T620M	DO52695	MALY	ICGC	VETST	DEG_SPOP_SBC_1	616:620	Mutation altering degron motif	0.7423
p.T618I	DO222413	MELA	ICGC	VETST	DEG_SPOP_SBC_1	616:620	Mutation altering degron motif	0.7078
p.Q14K	DO50733	ORCA	ICGC	LRQELTQIQ	DEG_APCC_DBOX_1	16:24	Mutation rewiring degron network	0.2778
p.T623M	DO33063	PACA	ICGC	VETST	DEG_SPOP_SBC_1	616:620	Mutation rewiring degron network	0.25
p.P46S	DO229275	THCA	ICGC	ITPRTE	DEG_SCF_FBW7_2	54:59	Mutation rewiring degron network	0.1111
p.N719K	DO229234	THCA	ICGC	APSSS	DEG_SPOP_SBC_1	728:732	Mutation rewiring degron network	0.0833
p.A734V	SIDM02017	Colorectal Carcinoma	GDSC	APSSS	DEG_SPOP_SBC_1	728:732	Mutation rewiring degron network	0.2778
p.G29S	SIDM00845	Burkitt's Lymphoma	GDSC	LRQELTQIQ	DEG_APCC_DBOX_1	16:24	Mutation rewiring degron network	0.1944
p.G29S	SIDM01519	Head and Neck Carcinoma	GDSC	LRQELTQIQ	DEG_APCC_DBOX_1	16:24	Mutation rewiring degron network	0.1944
p.T722S	SIDM00143	Small Cell Lung Carcinoma	GDSC	APSSS	DEG_SPOP_SBC_1	728:732	Mutation rewiring degron network	0.1667
p.T722S	ACH-000803	Lung Cancer	CCLE	APSSS	DEG_SPOP_SBC_1	728:732	Mutation rewiring degron network	0.1667
p.T722S	COLO-668	lung	COSMIC	APSSS	DEG_SPOP_SBC_1	728:732	Mutation rewiring degron network	0.1667
p.G866V	SIDM00114	Non-Small Cell Lung Carcinoma	GDSC	PYSSS	DEG_SPOP_SBC_1	853:857	Mutation rewiring degron network	0.0833
p.G866V	H513	pleura	COSMIC	PYSSS	DEG_SPOP_SBC_1	853:857	Mutation rewiring degron network	0.0833
p.S9C	SIDM00290	Gastric Carcinoma	GDSC	LRQELTQIQ	DEG_APCC_DBOX_1	16:24	Mutation rewiring degron network	0.1389
p.S9C	SIDM01444	Glioblastoma	GDSC	LRQELTQIQ	DEG_APCC_DBOX_1	16:24	Mutation rewiring degron network	0.1389
p.E740K	SIDM00250	Esophageal Squamous Cell Carcinoma	GDSC	APSSS	DEG_SPOP_SBC_1	728:732	Mutation rewiring degron network	0.1111
p.E740K	ACH-000917	Esophageal Cancer	CCLE	APSSS	DEG_SPOP_SBC_1	728:732	Mutation rewiring degron network	0.1111
p.E740K	TE-4	oesophagus	COSMIC	APSSS	DEG_SPOP_SBC_1	728:732	Mutation rewiring degron network	0.1111
p.L462V	SIDM00604	Oral Cavity Carcinoma	GDSC	RPTAQVLPV	DEG_SIAH_1	471:479	Mutation rewiring degron network	0.0833
p.L462V	KON	upper aerodigestive tract	COSMIC	RPTAQVLPV	DEG_SIAH_1	471:479	Mutation rewiring degron network	0.0833
p.G844S	SIDM01591	Breast Carcinoma	GDSC	PYSSS	DEG_SPOP_SBC_1	853:857	Mutation rewiring degron network	0.0833
p.G844S	ACH-000540	Non-Cancerous	CCLE	PYSSS	DEG_SPOP_SBC_1	853:857	Mutation rewiring degron network	0.0833
p.S68G	ACH-000157	Lymphoma	CCLE	ITPRTE	DEG_SCF_FBW7_2	54:59	Mutation rewiring degron network	0.0833
p.P733L	ACH-000820	Colon/Colorectal Cancer	CCLE	APSSS	DEG_SPOP_SBC_1	728:732	Mutation rewiring degron network	0.3056

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ZCCHC14

UniProt ID: Q8WYQ9

Entrez ID: 23174

Protein name: Zinc finger CCHC domain-containing protein 14 (BDG-29)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ZCCHC14 in