DegronMD

Uniprot ID: Q8WYQ9

Source protein: Zinc finger CCHC domain-containing protein 14

Source gene: ZCCHC14

Class: DEG_SCF_FBW7_2

Location: 54:59

E3 ligase: FBXW7

DEGRON score: 0.9007

ASA_SCORE: 91.3

COIL: 0.8555

CONS_SCORE: 0.4833

DSS_SCORE: 0.4776

HELIX: 0.0378

FCONS_SCORE: 0.8469

RIG_SCORE: 0.7236

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V62I	TCGA-A5-A0GB	UCEC	TCGA	ITPRTE	DEG_SCF_FBW7_2	0.25
p.V62I	DO41434	UCEC	ICGC	ITPRTE	DEG_SCF_FBW7_2	0.25
p.V65I	TCGA-CD-A4MI	STAD	TCGA	ITPRTE	DEG_SCF_FBW7_2	0.1667
p.V65I	DO47717	STAD	ICGC	ITPRTE	DEG_SCF_FBW7_2	0.1667
p.R57T	TCGA-CZ-5467	KIRC	TCGA	ITPRTE	DEG_SCF_FBW7_2	0.6765
p.R57T	DO16256	KIRC	ICGC	ITPRTE	DEG_SCF_FBW7_2	0.6765
p.I54V	DO229346	LAML	ICGC	ITPRTE	DEG_SCF_FBW7_2	0.5965
p.I54V	DO52365	LUSC	ICGC	ITPRTE	DEG_SCF_FBW7_2	0.5965
p.H52N	DO229015	LICA	ICGC	ITPRTE	DEG_SCF_FBW7_2	0.2778
p.P46S	DO229275	THCA	ICGC	ITPRTE	DEG_SCF_FBW7_2	0.1111
p.S68G	ACH-000157	Lymphoma	CCLE	ITPRTE	DEG_SCF_FBW7_2	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8WYQ9	Zinc finger CCHC domain-containing protein 14	DEG_SCF_FBW7_2	54:59	ITPRTE	FBXW7	0.9007	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons