DegronMD

Uniprot ID: Q8WYQ9

Source protein: Zinc finger CCHC domain-containing protein 14

Source gene: ZCCHC14

Class: DEG_SIAH_1

Location: 471:479

E3 ligase: SIAH1,SIAH2,SIAH3

DEGRON score: 0.9786

ASA_SCORE: 87.3111

COIL: 0.7859

CONS_SCORE: 0.9415

DSS_SCORE: 0.6272

HELIX: 0.0358

FCONS_SCORE: 1.3628

RIG_SCORE: 0.6791

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.F465S	TCGA-D1-A17Q	UCEC	TCGA	RPTAQVLPV	DEG_SIAH_1	0.1667
p.F465S	DO41903	UCEC	ICGC	RPTAQVLPV	DEG_SIAH_1	0.1667
p.L462V	SIDM00604	Oral Cavity Carcinoma	GDSC	RPTAQVLPV	DEG_SIAH_1	0.0833
p.L462V	KON	upper_aerodigestive_tract	COSMIC	RPTAQVLPV	DEG_SIAH_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8WYQ9	Zinc finger CCHC domain-containing protein 14	DEG_SIAH_1	471:479	RPTAQVLPV	SIAH1,SIAH2,SIAH3	0.9786	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons