DegronMD

Uniprot ID: Q8WYQ9

Source protein: Zinc finger CCHC domain-containing protein 14

Source gene: ZCCHC14

Class: DEG_APCC_DBOX_1

Location: 16:24

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6017

ASA_SCORE: 62.0556

COIL: 0.0497

CONS_SCORE: 0.5886

DSS_SCORE: 0.5766

HELIX: 0.9472

FCONS_SCORE: 1.154

RIG_SCORE: 0.7855

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R17L	TCGA-50-7109	LUAD	TCGA	LRQELTQIQ	DEG_APCC_DBOX_1	0.8428
p.R17L	DO24487	LUAD	ICGC	LRQELTQIQ	DEG_APCC_DBOX_1	0.8428
p.G31R	DO229493	LAML	ICGC	LRQELTQIQ	DEG_APCC_DBOX_1	0.1389
p.Q24L	DO23158	LINC	ICGC	LRQELTQIQ	DEG_APCC_DBOX_1	0.6654
p.Q14K	DO50733	ORCA	ICGC	LRQELTQIQ	DEG_APCC_DBOX_1	0.2778
p.G29S	SIDM00845	Burkitt's Lymphoma	GDSC	LRQELTQIQ	DEG_APCC_DBOX_1	0.1944
p.G29S	SIDM01519	Head and Neck Carcinoma	GDSC	LRQELTQIQ	DEG_APCC_DBOX_1	0.1944
p.S9C	SIDM00290	Gastric Carcinoma	GDSC	LRQELTQIQ	DEG_APCC_DBOX_1	0.1389
p.S9C	SIDM01444	Glioblastoma	GDSC	LRQELTQIQ	DEG_APCC_DBOX_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8WYQ9	Zinc finger CCHC domain-containing protein 14	DEG_APCC_DBOX_1	16:24	LRQELTQIQ	APC,CDC20,FZR1	0.6017	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons