DegronMD

Uniprot ID: Q8WYQ9

Source protein: Zinc finger CCHC domain-containing protein 14

Source gene: ZCCHC14

Class: DEG_SPOP_SBC_1

Location: 616:620

E3 ligase: SPOP

DEGRON score: 0.9657

ASA_SCORE: 87.42

COIL: 0.7678

CONS_SCORE: 0.7714

DSS_SCORE: 0.4472

HELIX: 0.0308

FCONS_SCORE: 1.1365

RIG_SCORE: 0.7781

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V616M	TCGA-AA-3672	COAD	TCGA	VETST	DEG_SPOP_SBC_1	0.7208
p.V616M	DO9010	COAD	ICGC	VETST	DEG_SPOP_SBC_1	0.7208
p.V616M	DO35083	PACA	ICGC	VETST	DEG_SPOP_SBC_1	0.7208
p.V616M	SIDM00282	Colorectal Carcinoma	GDSC	VETST	DEG_SPOP_SBC_1	0.7208
p.V616M	ACH-000998	Colon/Colorectal Cancer	CCLE	VETST	DEG_SPOP_SBC_1	0.7208
p.V616M	CW-2	large_intestine	COSMIC	VETST	DEG_SPOP_SBC_1	0.7208
p.T625M	TCGA-AX-A2HA	UCEC	TCGA	VETST	DEG_SPOP_SBC_1	0.1944
p.T625M	DO233903	GACA	ICGC	VETST	DEG_SPOP_SBC_1	0.1944
p.T625M	DO42504	UCEC	ICGC	VETST	DEG_SPOP_SBC_1	0.1944
p.A609V	TCGA-B5-A1MW	UCEC	TCGA	VETST	DEG_SPOP_SBC_1	0.1389
p.A609V	DO42913	UCEC	ICGC	VETST	DEG_SPOP_SBC_1	0.1389
p.G624E	TCGA-DF-A2KN	UCEC	TCGA	VETST	DEG_SPOP_SBC_1	0.2222
p.G624E	DO223282	UCEC	ICGC	VETST	DEG_SPOP_SBC_1	0.2222
p.V616A	TCGA-DI-A1BU	UCEC	TCGA	VETST	DEG_SPOP_SBC_1	0.5825
p.V616A	DO42023	UCEC	ICGC	VETST	DEG_SPOP_SBC_1	0.5825
p.K607N	TCGA-ER-A19F	SKCM	TCGA	VETST	DEG_SPOP_SBC_1	0.1944
p.K607N	DO37679	SKCM	ICGC	VETST	DEG_SPOP_SBC_1	0.1944
p.A622T	TCGA-F4-6703	COAD	TCGA	VETST	DEG_SPOP_SBC_1	0.2778
p.A622T	DO9908	COAD	ICGC	VETST	DEG_SPOP_SBC_1	0.2778
p.S627R	DO228948	LICA	ICGC	VETST	DEG_SPOP_SBC_1	0.1389
p.S627N	DO228967	LICA	ICGC	VETST	DEG_SPOP_SBC_1	0.1389
p.T620M	DO52695	MALY	ICGC	VETST	DEG_SPOP_SBC_1	0.7423
p.T618I	DO222413	MELA	ICGC	VETST	DEG_SPOP_SBC_1	0.7078
p.T623M	DO33063	PACA	ICGC	VETST	DEG_SPOP_SBC_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q13077	TNF receptor-associated factor 1	DEG_SPOP_SBC_1	412:416	VETST	SPOP	0.8512	More...
Q8WYQ9	Zinc finger CCHC domain-containing protein 14	DEG_SPOP_SBC_1	616:620	VETST	SPOP	0.9657	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons