DegronMD

Uniprot ID: Q13077

Source protein: TNF receptor-associated factor 1

Source gene: TRAF1

Class: DEG_SPOP_SBC_1

Location: 412:416

E3 ligase: SPOP

DEGRON score: 0.8512

ASA_SCORE: 89.1

COIL: 0.7962

CONS_SCORE: 0.6147

DSS_SCORE: 0.594

HELIX: 0.0036

FCONS_SCORE: 0.798

RIG_SCORE: 0.8348

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K402N	TCGA-EE-A2A0	SKCM	TCGA	VETST	DEG_SPOP_SBC_1	0.1667
p.L408I	TCGA-EE-A3AA	SKCM	TCGA	VETST	DEG_SPOP_SBC_1	0.2222
p.E413D	TCGA-ER-A19P	SKCM	TCGA	VETST	DEG_SPOP_SBC_1	0.5647

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q13077	TNF receptor-associated factor 1	DEG_SPOP_SBC_1	412:416	VETST	SPOP	0.8512	More...
Q8WYQ9	Zinc finger CCHC domain-containing protein 14	DEG_SPOP_SBC_1	616:620	VETST	SPOP	0.9657	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons