TRAF1
UniProt ID: Q13077
Entrez ID: 7185
Protein name: TNF receptor-associated factor 1 (Epstein-Barr virus-induced protein 6)
External links: UniprotKB HGNC RefSeq COSMIC
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FUNCTION: Adapter molecule that regulates the activation of NF-kappa-B and JNK. Plays a role in the regulation of cell survival and apoptosis. The heterotrimer formed by TRAF1 and TRAF2 is part of a E3 ubiquitin-protein ligase complex that promotes ubiquitination of target proteins, such as MAP3K14....
FUNCTION: Adapter molecule that regulates the activation of NF-kappa-B and JNK. Plays a role in the regulation of cell survival and apoptosis. The heterotrimer formed by TRAF1 and TRAF2 is part of a E3 ubiquitin-protein ligase complex that promotes ubiquitination of target proteins, such as MAP3K14. The TRAF1/TRAF2 complex recruits the antiapoptotic E3 protein-ubiquitin ligases BIRC2 and BIRC3 to TNFRSF1B/TNFR2. {ECO:0000269|PubMed:10692572, ECO:0000269|PubMed:16323247, ECO:0000269|PubMed:18429822, ECO:0000269|PubMed:19287455, ECO:0000269|PubMed:19698991, ECO:0000269|PubMed:20385093}.
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GO - Biological processes (BP):
apoptotic process [GO:0006915]; positive regulation of JNK cascade [GO:0046330]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; protein-containing complex assembly [GO:0065003]; protein K63-linked ubiquitination [GO:0070534]; regulation of extrinsic apoptotic signaling ...
apoptotic process [GO:0006915]; positive regulation of JNK cascade [GO:0046330]; positive regulation of NF-kappaB transcription factor activity [GO:0051092]; protein-containing complex assembly [GO:0065003]; protein K63-linked ubiquitination [GO:0070534]; regulation of extrinsic apoptotic signaling pathway [GO:2001236]; regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043122]; tumor necrosis factor-mediated signaling pathway [GO:0033209]
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GO - Molecular function (MF):
identical protein binding [GO:0042802]; thioesterase binding [GO:0031996]; tumor necrosis factor receptor binding [GO:0005164]; ubiquitin protein ligase binding [GO:0031625]; zinc ion binding [GO:0008270]...
identical protein binding [GO:0042802]; thioesterase binding [GO:0031996]; tumor necrosis factor receptor binding [GO:0005164]; ubiquitin protein ligase binding [GO:0031625]; zinc ion binding [GO:0008270]
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GO - Cellular component (CC):
cytoplasm [GO:0005737]; cytoplasmic side of plasma membrane [GO:0009898]; cytosol [GO:0005829]...
cytoplasm [GO:0005737]; cytoplasmic side of plasma membrane [GO:0009898]; cytosol [GO:0005829]
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TRAF1
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*NOTE: the Kaplan plots were collected from OncoLnc