DegronMD

Uniprot ID: A7KAX9

Source protein: Rho GTPase-activating protein 32

Source gene: ARHGAP32

Class: DEG_SPOP_SBC_1

Location: 1652:1656

E3 ligase: SPOP

DEGRON score: 0.9915

ASA_SCORE: 92.24

COIL: 0.9422

CONS_SCORE: 0.4089

DSS_SCORE: 0.3681

HELIX: 0.0288

FCONS_SCORE: 1.1177

RIG_SCORE: 0.6553

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R1645Q	TCGA-CK-5913	COAD	TCGA	PYSSS	DEG_SPOP_SBC_1	0.1389
p.R1645W	TCGA-HU-A4GP	STAD	TCGA	PYSSS	DEG_SPOP_SBC_1	0.1389
p.S1657C	TCGA-VS-A9UC	CESC	TCGA	PYSSS	DEG_SPOP_SBC_1	0.3056
p.S1653C	DO219014	BLCA	ICGC	PYSSS	DEG_SPOP_SBC_1	0.7541
p.G1662V	DO767	BLCA	ICGC	PYSSS	DEG_SPOP_SBC_1	0.1667
p.Q1657K	DO229029	LICA	ICGC	PYSSS	DEG_SPOP_SBC_1	0.3056
p.Q1657K	DO229027	LICA	ICGC	PYSSS	DEG_SPOP_SBC_1	0.3056
p.S1666R	DO25104	LUAD	ICGC	PYSSS	DEG_SPOP_SBC_1	0.0556
p.D1651N	DO26444	LUSC	ICGC	PYSSS	DEG_SPOP_SBC_1	0.3056
p.P1652T	DO232761	PBCA	ICGC	PYSSS	DEG_SPOP_SBC_1	0.7031
p.R1664H	DO51407	PRAD	ICGC	PYSSS	DEG_SPOP_SBC_1	0.1111
p.V1648M	DO50078	UCEC	ICGC	PYSSS	DEG_SPOP_SBC_1	0.2222
p.R1664C	DO41199	UCEC	ICGC	PYSSS	DEG_SPOP_SBC_1	0.1111
p.G1644V	SIDM01156	Small Cell Lung Carcinoma	GDSC	PYSSS	DEG_SPOP_SBC_1	0.1111
p.G1644V	SW1271	lung	COSMIC	PYSSS	DEG_SPOP_SBC_1	0.1111
p.A1666V	SIDM00438	B-Lymphoblastic Leukemia	GDSC	PYSSS	DEG_SPOP_SBC_1	0.0556
p.A1666V	MN-60	haematopoietic_and_lymphoid_tissue	COSMIC	PYSSS	DEG_SPOP_SBC_1	0.0556
p.R1650S	ACH-001061	Colon/Colorectal Cancer	CCLE	PYSSS	DEG_SPOP_SBC_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A7KAX9	Rho GTPase-activating protein 32	DEG_SPOP_SBC_1	1652:1656	PYSSS	SPOP	0.9915	More...
A8MQ03	Cysteine-rich tail protein 1	DEG_SPOP_SBC_1	90:94	PYSSS	SPOP	0.6254	More...
O43166	Signal-induced proliferation-associated 1-like protein 1	DEG_SPOP_SBC_1	1726:1730	PYSSS	SPOP	0.9278	More...
P54259	Atrophin-1	DEG_SPOP_SBC_1	374:378	PYSSS	SPOP	0.9833	More...
Q14004	Cyclin-dependent kinase 13	DEG_SPOP_SBC_1	386:390	PYSSS	SPOP	0.9958	More...
Q92922	SWI/SNF complex subunit SMARCC1	DEG_SPOP_SBC_1	208:212	PYSSS	SPOP	0.9771	More...
Q9BWW4	Single-stranded DNA-binding protein 3	DEG_SPOP_SBC_1	257:261	PYSSS	SPOP	0.685	More...
Q9NZM3	Intersectin-2	DEG_SPOP_SBC_1	181:185	PYSSS	SPOP	0.983	More...
Q9UL40	Zinc finger protein 346	DEG_SPOP_SBC_1	19:23	PYSSS	SPOP	0.9528	More...
Q9UQB3	Catenin delta-2	DEG_SPOP_SBC_1	1050:1054	PYSSS	SPOP	0.7199	More...
Q9Y5X4	Photoreceptor-specific nuclear receptor	DEG_SPOP_SBC_1	208:212	PYSSS	SPOP	0.9744	More...
Q8WYQ9	Zinc finger CCHC domain-containing protein 14	DEG_SPOP_SBC_1	853:857	PYSSS	SPOP	0.6609	More...
Q53SF7	Cordon-bleu protein-like 1	DEG_SPOP_SBC_1	979:983	PYSSS	SPOP	0.9833	More...
Q9BWG4	Single-stranded DNA-binding protein 4	DEG_SPOP_SBC_1	252:256	PYSSS	SPOP	0.9926	More...
Q9BZE3	BarH-like 1 homeobox protein	DEG_SPOP_SBC_1	113:117	PYSSS	SPOP	0.8569	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons