DegronMD

Uniprot ID: Q14004

Source protein: Cyclin-dependent kinase 13

Source gene: CDK13

Class: DEG_SPOP_SBC_1

Location: 386:390

E3 ligase: SPOP

DEGRON score: 0.9958

ASA_SCORE: 86.92

COIL: 0.9062

CONS_SCORE: 0.3585

DSS_SCORE: 0.5211

HELIX: 0.0794

FCONS_SCORE: 1.0661

RIG_SCORE: 0.5795

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Y376H	TCGA-CZ-5982	KIRC	TCGA	PYSSS	DEG_SPOP_SBC_1	0.5
p.Y376H	DO16550	KIRC	ICGC	PYSSS	DEG_SPOP_SBC_1	0.5
p.R393H	TCGA-HU-A4H4	STAD	TCGA	PYSSS	DEG_SPOP_SBC_1	0.25
p.R393H	DO47721	STAD	ICGC	PYSSS	DEG_SPOP_SBC_1	0.25
p.S400I	TCGA-IB-7651	PAAD	TCGA	PYSSS	DEG_SPOP_SBC_1	0.5
p.S400I	DO46657	PAAD	ICGC	PYSSS	DEG_SPOP_SBC_1	0.5
p.S390N	TCGA-VQ-A8P2	STAD	TCGA	PYSSS	DEG_SPOP_SBC_1	0.7069
p.S390N	DO51761	STAD	ICGC	PYSSS	DEG_SPOP_SBC_1	0.7069
p.S388I	DO229019	LICA	ICGC	PYSSS	DEG_SPOP_SBC_1	0.7341
p.S395C	SIDM01251	T-Cell Non-Hodgkin's Lymphoma	GDSC	PYSSS	DEG_SPOP_SBC_1	0.6389
p.S395C	ACH-002240	Lymphoma	CCLE	PYSSS	DEG_SPOP_SBC_1	0.6389
p.S395C	H9	haematopoietic_and_lymphoid_tissue	COSMIC	PYSSS	DEG_SPOP_SBC_1	0.6389
p.S383P	SIDM00537	Colorectal Carcinoma	GDSC	PYSSS	DEG_SPOP_SBC_1	0.6944
p.S383P	ACH-000982	Colon/Colorectal Cancer	CCLE	PYSSS	DEG_SPOP_SBC_1	0.6944
p.S383P	ACH-001345	Colon/Colorectal Cancer	CCLE	PYSSS	DEG_SPOP_SBC_1	0.6944
p.S383P	GP5d	large_intestine	COSMIC	PYSSS	DEG_SPOP_SBC_1	0.6944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A7KAX9	Rho GTPase-activating protein 32	DEG_SPOP_SBC_1	1652:1656	PYSSS	SPOP	0.9915	More...
A8MQ03	Cysteine-rich tail protein 1	DEG_SPOP_SBC_1	90:94	PYSSS	SPOP	0.6254	More...
O43166	Signal-induced proliferation-associated 1-like protein 1	DEG_SPOP_SBC_1	1726:1730	PYSSS	SPOP	0.9278	More...
P54259	Atrophin-1	DEG_SPOP_SBC_1	374:378	PYSSS	SPOP	0.9833	More...
Q14004	Cyclin-dependent kinase 13	DEG_SPOP_SBC_1	386:390	PYSSS	SPOP	0.9958	More...
Q92922	SWI/SNF complex subunit SMARCC1	DEG_SPOP_SBC_1	208:212	PYSSS	SPOP	0.9771	More...
Q9BWW4	Single-stranded DNA-binding protein 3	DEG_SPOP_SBC_1	257:261	PYSSS	SPOP	0.685	More...
Q9NZM3	Intersectin-2	DEG_SPOP_SBC_1	181:185	PYSSS	SPOP	0.983	More...
Q9UL40	Zinc finger protein 346	DEG_SPOP_SBC_1	19:23	PYSSS	SPOP	0.9528	More...
Q9UQB3	Catenin delta-2	DEG_SPOP_SBC_1	1050:1054	PYSSS	SPOP	0.7199	More...
Q9Y5X4	Photoreceptor-specific nuclear receptor	DEG_SPOP_SBC_1	208:212	PYSSS	SPOP	0.9744	More...
Q8WYQ9	Zinc finger CCHC domain-containing protein 14	DEG_SPOP_SBC_1	853:857	PYSSS	SPOP	0.6609	More...
Q53SF7	Cordon-bleu protein-like 1	DEG_SPOP_SBC_1	979:983	PYSSS	SPOP	0.9833	More...
Q9BWG4	Single-stranded DNA-binding protein 4	DEG_SPOP_SBC_1	252:256	PYSSS	SPOP	0.9926	More...
Q9BZE3	BarH-like 1 homeobox protein	DEG_SPOP_SBC_1	113:117	PYSSS	SPOP	0.8569	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons