DegronMD - Q14004(CDK13)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R1426I	TCGA-19-5956	GBM	TCGA	DHRFEYSHGP	CBL_PTK	1424:1433	Mutation altering degron motif	0.6991
p.R1426I	DO13863	GBM	ICGC	DHRFEYSHGP	CBL_PTK	1424:1433	Mutation altering degron motif	0.6991
p.D1144Y	TCGA-A5-A1OF	UCEC	TCGA	PSTPQQE	DEG_SCF_FBW7_2	1145:1151	Mutation rewiring degron network	0.3056
p.D1144Y	DO42568	UCEC	ICGC	PSTPQQE	DEG_SCF_FBW7_2	1145:1151	Mutation rewiring degron network	0.3056
p.S1153L	TCGA-AX-A0J0	UCEC	TCGA	PSTPQQE	DEG_SCF_FBW7_2	1145:1151	Mutation blocking phosphorylation signal	0.7222
p.S1153L	TCGA-BR-8680	STAD	TCGA	PSTPQQE	DEG_SCF_FBW7_2	1145:1151	Mutation blocking phosphorylation signal	0.7222
p.Y376H	TCGA-CZ-5982	KIRC	TCGA	PYSSS	DEG_SPOP_SBC_1	386:390	Mutation blocking phosphorylation signal	0.5
p.Y376H	DO16550	KIRC	ICGC	PYSSS	DEG_SPOP_SBC_1	386:390	Mutation blocking phosphorylation signal	0.5
p.F1419L	TCGA-DI-A1BU	UCEC	TCGA	DHRFEYSHGP	CBL_PTK	1424:1433	Mutation rewiring degron network	0.1944
p.F1419L	DO42023	UCEC	ICGC	DHRFEYSHGP	CBL_PTK	1424:1433	Mutation rewiring degron network	0.1944
p.T1287I	TCGA-DU-6392	LGG	TCGA	VPTTS	DEG_SPOP_SBC_1	1284:1288	Mutation altering degron motif	0.7078
p.Q1149H	TCGA-EO-A22X	UCEC	TCGA	PSTPQQE	DEG_SCF_FBW7_2	1145:1151	Mutation altering degron motif	0.647
p.A1137T	TCGA-HU-A4G8	STAD	TCGA	PSTPQQE	DEG_SCF_FBW7_2	1145:1151	Mutation rewiring degron network	0.1111
p.A1137T	DO47819	STAD	ICGC	PSTPQQE	DEG_SCF_FBW7_2	1145:1151	Mutation rewiring degron network	0.1111
p.R393H	TCGA-HU-A4H4	STAD	TCGA	PYSSS	DEG_SPOP_SBC_1	386:390	Mutation rewiring degron network	0.25
p.R393H	DO47721	STAD	ICGC	PYSSS	DEG_SPOP_SBC_1	386:390	Mutation rewiring degron network	0.25
p.S400I	TCGA-IB-7651	PAAD	TCGA	PYSSS	DEG_SPOP_SBC_1	386:390	Mutation blocking phosphorylation signal	0.5
p.S400I	DO46657	PAAD	ICGC	PYSSS	DEG_SPOP_SBC_1	386:390	Mutation blocking phosphorylation signal	0.5
p.P1269L	TCGA-LD-A74U	BRCA	TCGA	DYR	CBL_MET	1276:1278	Mutation rewiring degron network	0.1389
p.S390N	TCGA-VQ-A8P2	STAD	TCGA	PYSSS	DEG_SPOP_SBC_1	386:390	Mutation altering degron motif	0.7069
p.S390N	DO51761	STAD	ICGC	PYSSS	DEG_SPOP_SBC_1	386:390	Mutation altering degron motif	0.7069
p.S1271C	DO477	BLCA	ICGC	DYR	CBL_MET	1276:1278	Mutation rewiring degron network	0.1944
p.K1139T	DO224895	BRCA	ICGC	PSTPQQE	DEG_SCF_FBW7_2	1145:1151	Mutation rewiring degron network	0.1667
p.N1292S	DO8264	COAD	ICGC	VPTTS	DEG_SPOP_SBC_1	1284:1288	Mutation rewiring degron network	0.2222
p.S268R	DO234276	ESAD	ICGC	ATSSS	DEG_SPOP_SBC_1	263:267	Mutation blocking phosphorylation signal	0.75
p.S184P	DO233935	GACA	ICGC	PASSS	DEG_SPOP_SBC_1	181:185	Mutation altering degron motif	0.6752
p.S388I	DO229019	LICA	ICGC	PYSSS	DEG_SPOP_SBC_1	386:390	Mutation altering degron motif	0.7341
p.H1431R	DO231909	LINC	ICGC	DHRFEYSHGP	CBL_PTK	1424:1433	Mutation altering degron motif	0.7133
p.G175V	DO232761	PBCA	ICGC	PASSS	DEG_SPOP_SBC_1	181:185	Mutation rewiring degron network	0.1667
p.S260R	DO36556	READ	ICGC	ATSSS	DEG_SPOP_SBC_1	263:267	Mutation blocking phosphorylation signal	0.6944
p.P181A	DO47072	RECA	ICGC	PASSS	DEG_SPOP_SBC_1	181:185	Mutation altering degron motif	0.6392
p.V1270M	DO220163	SARC	ICGC	DYR	CBL_MET	1276:1278	Mutation rewiring degron network	0.1667
p.R1435S	DO47623	SKCM	ICGC	DHRFEYSHGP	CBL_PTK	1424:1433	Mutation rewiring degron network	0.2778
p.H1431L	DO38404	STAD	ICGC	DHRFEYSHGP	CBL_PTK	1424:1433	Mutation altering degron motif	0.6202
p.L319V	DO229272	THCA	ICGC	RRRSLSPLG	DEG_APCC_DBOX_1	312:320	Mutation altering degron motif	0.5654
p.R257C	DO229213	THCA	ICGC	ATSSS	DEG_SPOP_SBC_1	263:267	Mutation rewiring degron network	0.1667
p.S254G	DO229092	THCA	ICGC	ATSSS	DEG_SPOP_SBC_1	263:267	Mutation rewiring degron network	0.0833
p.N1278S	DO43578	UCEC	ICGC	DYR	CBL_MET	1276:1278	Mutation altering degron motif	0.7069
p.P1155S	SIDM00845	Burkitt's Lymphoma	GDSC	PSTPQQE	DEG_SCF_FBW7_2	1145:1151	Mutation rewiring degron network	0.2222
p.S1441N	SIDM00845	Burkitt's Lymphoma	GDSC	DHRFEYSHGP	CBL_PTK	1424:1433	Mutation rewiring degron network	0.1111
p.S395C	SIDM01251	T-Cell Non-Hodgkin's Lymphoma	GDSC	PYSSS	DEG_SPOP_SBC_1	386:390	Mutation blocking phosphorylation signal	0.6389
p.S395C	ACH-002240	Lymphoma	CCLE	PYSSS	DEG_SPOP_SBC_1	386:390	Mutation blocking phosphorylation signal	0.6389
p.S395C	H9	haematopoietic and lymphoid tissue	COSMIC	PYSSS	DEG_SPOP_SBC_1	386:390	Mutation blocking phosphorylation signal	0.6389
p.R1278Q	SIDM00660	Colorectal Carcinoma	GDSC	DYR	CBL_MET	1276:1278	Mutation altering degron motif	0.7329
p.R1278Q	ACH-000985	Colon/Colorectal Cancer	CCLE	DYR	CBL_MET	1276:1278	Mutation altering degron motif	0.7329
p.R1278Q	LS-411N	large intestine	COSMIC	DYR	CBL_MET	1276:1278	Mutation altering degron motif	0.7329
p.S383P	SIDM00537	Colorectal Carcinoma	GDSC	PYSSS	DEG_SPOP_SBC_1	386:390	Mutation blocking phosphorylation signal	0.6944
p.S383P	ACH-000982	Colon/Colorectal Cancer	CCLE	PYSSS	DEG_SPOP_SBC_1	386:390	Mutation blocking phosphorylation signal	0.6944
p.S383P	ACH-001345	Colon/Colorectal Cancer	CCLE	PYSSS	DEG_SPOP_SBC_1	386:390	Mutation blocking phosphorylation signal	0.6944
p.S383P	GP5d	large intestine	COSMIC	PYSSS	DEG_SPOP_SBC_1	386:390	Mutation blocking phosphorylation signal	0.6944
p.E1266K	SIDM00988	Kidney Carcinoma	GDSC	DYR	CBL_MET	1276:1278	Mutation rewiring degron network	0.0556
p.E1266K	ACH-000792	Kidney Cancer	CCLE	DYR	CBL_MET	1276:1278	Mutation rewiring degron network	0.0556
p.E1266K	BFTC-909	kidney	COSMIC	DYR	CBL_MET	1276:1278	Mutation rewiring degron network	0.0556
p.P1443T	SIDM00956	Esophageal Squamous Cell Carcinoma	GDSC	DHRFEYSHGP	CBL_PTK	1424:1433	Mutation rewiring degron network	0.0556
p.P1443T	ACH-000717	Esophageal Cancer	CCLE	DHRFEYSHGP	CBL_PTK	1424:1433	Mutation rewiring degron network	0.0556
p.P1443T	COLO-680N	oesophagus	COSMIC	DHRFEYSHGP	CBL_PTK	1424:1433	Mutation rewiring degron network	0.0556
p.H1283Y	ACH-000612	Lymphoma	CCLE	VPTTS	DEG_SPOP_SBC_1	1284:1288	Mutation rewiring degron network	0.3056
p.H1283Y	ACH-000612	Lymphoma	CCLE	DYR	CBL_MET	1276:1278	Mutation rewiring degron network	0.1944
p.D323N	ACH-000690	Lung Cancer	CCLE	RRRSLSPLG	DEG_APCC_DBOX_1	312:320	Mutation rewiring degron network	0.25
p.G186D	ACH-000969	Colon/Colorectal Cancer	CCLE	PASSS	DEG_SPOP_SBC_1	181:185	Mutation rewiring degron network	0.3056
p.T1442A	Daudi	haematopoietic and lymphoid tissue	COSMIC	DHRFEYSHGP	CBL_PTK	1424:1433	Mutation rewiring degron network	0.0833
p.T1442A	OCI-AML5	haematopoietic and lymphoid tissue	COSMIC	DHRFEYSHGP	CBL_PTK	1424:1433	Mutation rewiring degron network	0.0833
p.G1280R	KYSE-150	oesophagus	COSMIC	VPTTS	DEG_SPOP_SBC_1	1284:1288	Mutation rewiring degron network	0.2222
p.G1280R	KYSE-150	oesophagus	COSMIC	DYR	CBL_MET	1276:1278	Mutation rewiring degron network	0.2778
p.G171C	SNU-1040	large intestine	COSMIC	PASSS	DEG_SPOP_SBC_1	181:185	Mutation rewiring degron network	0.0556
p.T146S	NB14	autonomic ganglia	COSMIC	VTPLVE	DEG_SCF_FBW7_2	140:145	Mutation rewiring degron network	0.3056
p.G1151E	WSU-NHL	haematopoietic and lymphoid tissue	COSMIC	PSTPQQE	DEG_SCF_FBW7_2	1145:1151	Mutation altering degron motif	0.7199
p.M153T	SNU-1040	large intestine	COSMIC	VTPLVE	DEG_SCF_FBW7_2	140:145	Mutation rewiring degron network	0.1111
p.M1416T	SNG-M	endometrium	COSMIC	DHRFEYSHGP	CBL_PTK	1424:1433	Mutation rewiring degron network	0.1111

Kaplan plot for CDK13 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CDK13

UniProt ID: Q14004

Entrez ID: 8621

Protein name: Cyclin-dependent kinase 13 (EC 2.7.11.22) (EC 2.7.11.23) (CDC2-related protein kinase 5) (Cell division cycle 2-like protein kinase 5) (Cell division protein kinase 13) (hCDK13) (Cholinesterase-related cell division controller)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CDK13 in