DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
VTPLVE
Uniprot ID:
Q14004
Source protein:
Cyclin-dependent kinase 13
Source gene:
CDK13
Class:
DEG_SCF_FBW7_2
Location:
140:145
E3 ligase:
FBXW7
DEGRON score:
0.9991
ASA_SCORE:
76.2333
COIL:
0.7668
CONS_SCORE:
0.3581
DSS_SCORE:
0.6007
HELIX:
0.057
FCONS_SCORE:
1.087
RIG_SCORE:
0.7472
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.T146S
NB14
autonomic_ganglia
COSMIC
VTPLVE
DEG_SCF_FBW7_2
0.3056
p.M153T
SNU-1040
large_intestine
COSMIC
VTPLVE
DEG_SCF_FBW7_2
0.1111
Drug responses associated with CDK13 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of VTPLVE
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q14004
Cyclin-dependent kinase 13
DEG_SCF_FBW7_2
140:145
VTPLVE
FBXW7
0.9991
More...