DegronMD

Uniprot ID: Q14004

Source protein: Cyclin-dependent kinase 13

Source gene: CDK13

Class: DEG_SCF_FBW7_2

Location: 1145:1151

E3 ligase: FBXW7

DEGRON score: 0.8992

ASA_SCORE: 100.6

COIL: 0.9241

CONS_SCORE: 0.3658

DSS_SCORE: 0.8148

HELIX: 0.0519

FCONS_SCORE: 1.491

RIG_SCORE: 0.5938

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D1144Y	TCGA-A5-A1OF	UCEC	TCGA	PSTPQQE	DEG_SCF_FBW7_2	0.3056
p.D1144Y	DO42568	UCEC	ICGC	PSTPQQE	DEG_SCF_FBW7_2	0.3056
p.S1153L	TCGA-AX-A0J0	UCEC	TCGA	PSTPQQE	DEG_SCF_FBW7_2	0.7222
p.S1153L	TCGA-BR-8680	STAD	TCGA	PSTPQQE	DEG_SCF_FBW7_2	0.7222
p.Q1149H	TCGA-EO-A22X	UCEC	TCGA	PSTPQQE	DEG_SCF_FBW7_2	0.647
p.A1137T	TCGA-HU-A4G8	STAD	TCGA	PSTPQQE	DEG_SCF_FBW7_2	0.1111
p.A1137T	DO47819	STAD	ICGC	PSTPQQE	DEG_SCF_FBW7_2	0.1111
p.K1139T	DO224895	BRCA	ICGC	PSTPQQE	DEG_SCF_FBW7_2	0.1667
p.P1155S	SIDM00845	Burkitt's Lymphoma	GDSC	PSTPQQE	DEG_SCF_FBW7_2	0.2222
p.G1151E	WSU-NHL	haematopoietic_and_lymphoid_tissue	COSMIC	PSTPQQE	DEG_SCF_FBW7_2	0.7199

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q14004	Cyclin-dependent kinase 13	DEG_SCF_FBW7_2	1145:1151	PSTPQQE	FBXW7	0.8992	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons