DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
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Degron:
RRRSLSPLG
Uniprot ID:
Q14004
Source protein:
Cyclin-dependent kinase 13
Source gene:
CDK13
Class:
DEG_APCC_DBOX_1
Location:
312:320
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.9912
ASA_SCORE:
112.2778
COIL:
0.9119
CONS_SCORE:
0.3317
DSS_SCORE:
0.7113
HELIX:
0.0629
FCONS_SCORE:
1.0157
RIG_SCORE:
0.6151
Degron related mutations and impact score
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Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.L319V
DO229272
THCA
ICGC
RRRSLSPLG
DEG_APCC_DBOX_1
0.5654
p.D323N
ACH-000690
Lung Cancer
CCLE
RRRSLSPLG
DEG_APCC_DBOX_1
0.25
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Drug responses associated with CDK13 mutations
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Mutation (In Degron?)
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IC50
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All proteins holding degron of RRRSLSPLG
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Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q14004
Cyclin-dependent kinase 13
DEG_APCC_DBOX_1
312:320
RRRSLSPLG
APC,CDC20,FZR1
0.9912
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