DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
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CGC
Degron:
RRRSLSPLG
Uniprot ID:
Q14004
Source protein:
Cyclin-dependent kinase 13
Source gene:
CDK13
Class:
DEG_APCC_DBOX_1
Location:
312:320
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.9912
ASA_SCORE:
112.2778
COIL:
0.9119
CONS_SCORE:
0.3317
DSS_SCORE:
0.7113
HELIX:
0.0629
FCONS_SCORE:
1.0157
RIG_SCORE:
0.6151
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.L319V
DO229272
THCA
ICGC
RRRSLSPLG
DEG_APCC_DBOX_1
0.5654
p.D323N
ACH-000690
Lung Cancer
CCLE
RRRSLSPLG
DEG_APCC_DBOX_1
0.25
Drug responses associated with CDK13 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of RRRSLSPLG
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q14004
Cyclin-dependent kinase 13
DEG_APCC_DBOX_1
312:320
RRRSLSPLG
APC,CDC20,FZR1
0.9912
More...