DegronMD

Uniprot ID: Q14004

Source protein: Cyclin-dependent kinase 13

Source gene: CDK13

Class: CBL_PTK

Location: 1424:1433

E3 ligase: CBL

DEGRON score: 0.9417

ASA_SCORE: 64.25

COIL: 0.734

CONS_SCORE: 0.1824

DSS_SCORE: 0.386

HELIX: 0.1146

FCONS_SCORE: 0.8641

RIG_SCORE: 0.7308

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R1426I	TCGA-19-5956	GBM	TCGA	DHRFEYSHGP	CBL_PTK	0.6991
p.R1426I	DO13863	GBM	ICGC	DHRFEYSHGP	CBL_PTK	0.6991
p.F1419L	TCGA-DI-A1BU	UCEC	TCGA	DHRFEYSHGP	CBL_PTK	0.1944
p.F1419L	DO42023	UCEC	ICGC	DHRFEYSHGP	CBL_PTK	0.1944
p.H1431R	DO231909	LINC	ICGC	DHRFEYSHGP	CBL_PTK	0.7133
p.R1435S	DO47623	SKCM	ICGC	DHRFEYSHGP	CBL_PTK	0.2778
p.H1431L	DO38404	STAD	ICGC	DHRFEYSHGP	CBL_PTK	0.6202
p.S1441N	SIDM00845	Burkitt's Lymphoma	GDSC	DHRFEYSHGP	CBL_PTK	0.1111
p.P1443T	SIDM00956	Esophageal Squamous Cell Carcinoma	GDSC	DHRFEYSHGP	CBL_PTK	0.0556
p.P1443T	ACH-000717	Esophageal Cancer	CCLE	DHRFEYSHGP	CBL_PTK	0.0556
p.P1443T	COLO-680N	oesophagus	COSMIC	DHRFEYSHGP	CBL_PTK	0.0556
p.T1442A	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	DHRFEYSHGP	CBL_PTK	0.0833
p.T1442A	OCI-AML5	haematopoietic_and_lymphoid_tissue	COSMIC	DHRFEYSHGP	CBL_PTK	0.0833
p.M1416T	SNG-M	endometrium	COSMIC	DHRFEYSHGP	CBL_PTK	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q14004	Cyclin-dependent kinase 13	CBL_PTK	1424:1433	DHRFEYSHGP	CBL	0.9417	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons