DegronMD

Uniprot ID: Q9UQB3

Source protein: Catenin delta-2

Source gene: CTNND2

Class: DEG_Kelch_Keap1_1

Location: 141:146

E3 ligase: KEAP1

DEGRON score: 0.836

ASA_SCORE: 79.8667

COIL: 0.8343

CONS_SCORE: 0.269

DSS_SCORE: 0.5445

HELIX: 0.0908

FCONS_SCORE: 0.898

RIG_SCORE: 0.6906

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q142H	DO9002	COAD	ICGC	DYSTGE	DEG_Kelch_Keap1_1	0.7582
p.A145T	DO45494	LUSC	ICGC	DYSTGE	DEG_Kelch_Keap1_1	0.7139
p.A146T	MDA-MB-157	breast	COSMIC	DYSTGE	DEG_Kelch_Keap1_1	0.7139
p.A146V	DO9756	COAD	ICGC	DYSTGE	DEG_Kelch_Keap1_1	0.6936
p.A146V	DO219138	LUSC	ICGC	DYSTGE	DEG_Kelch_Keap1_1	0.6936
p.A146V	DO27835	MALY	ICGC	DYSTGE	DEG_Kelch_Keap1_1	0.6936
p.N143K	NCI-H2066	lung	COSMIC	DYSTGE	DEG_Kelch_Keap1_1	0.6918
p.Q142E	DO49067	HNSC	ICGC	DYSTGE	DEG_Kelch_Keap1_1	0.6744
p.G140S	DO7781	COAD	ICGC	DYSTGE	DEG_Kelch_Keap1_1	0.3056
p.G140S	DO7804	COAD	ICGC	DYSTGE	DEG_Kelch_Keap1_1	0.3056
p.G140S	SIMA	autonomic_ganglia	COSMIC	DYSTGE	DEG_Kelch_Keap1_1	0.3056
p.A147S	DO45442	LUSC	ICGC	DYSTGE	DEG_Kelch_Keap1_1	0.3056
p.G140D	DO218863	SKCA	ICGC	DYSTGE	DEG_Kelch_Keap1_1	0.3056
p.A147V	DO223907	SKCM	ICGC	DYSTGE	DEG_Kelch_Keap1_1	0.3056
p.P139Q	TCGA-33-4583	LUSC	TCGA	DYSTGE	DEG_Kelch_Keap1_1	0.2778
p.H139Q	DO14173	HNSC	ICGC	DYSTGE	DEG_Kelch_Keap1_1	0.2778
p.T148A	DO36556	READ	ICGC	DYSTGE	DEG_Kelch_Keap1_1	0.2778
p.L150M	TCGA-66-2782	LUSC	TCGA	DYSTGE	DEG_Kelch_Keap1_1	0.2222
p.L150M	DO26680	LUSC	ICGC	DYSTGE	DEG_Kelch_Keap1_1	0.2222
p.Q150H	DO14654	HNSC	ICGC	DYSTGE	DEG_Kelch_Keap1_1	0.2222
p.L150R	SIDM00302	Other Solid Cancers	GDSC	DYSTGE	DEG_Kelch_Keap1_1	0.2222
p.L150R	ACH-002149	Ovarian Cancer	CCLE	DYSTGE	DEG_Kelch_Keap1_1	0.2222
p.L150R	KGN	ovary	COSMIC	DYSTGE	DEG_Kelch_Keap1_1	0.2222
p.L151F	TCGA-A5-A0G1	UCEC	TCGA	DYSTGE	DEG_Kelch_Keap1_1	0.1944
p.L151F	DO42472	UCEC	ICGC	DYSTGE	DEG_Kelch_Keap1_1	0.1944

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UQB3	Catenin delta-2	DEG_Kelch_Keap1_1	141:146	DYSTGE	KEAP1	0.836	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons