DegronMD

Uniprot ID: Q9UQB3

Source protein: Catenin delta-2

Source gene: CTNND2

Class: DEG_Kelch_Keap1_1

Location: 141:146

E3 ligase: KEAP1

DEGRON score: 0.836

ASA_SCORE: 79.8667

COIL: 0.8343

CONS_SCORE: 0.269

DSS_SCORE: 0.5445

HELIX: 0.0908

FCONS_SCORE: 0.898

RIG_SCORE: 0.6906

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P139Q	TCGA-33-4583	LUSC	TCGA	DYSTGE	DEG_Kelch_Keap1_1	0.2778
p.Q132K	TCGA-50-5933	LUAD	TCGA	DYSTGE	DEG_Kelch_Keap1_1	0.0833
p.L150M	TCGA-66-2782	LUSC	TCGA	DYSTGE	DEG_Kelch_Keap1_1	0.2222
p.L150M	DO26680	LUSC	ICGC	DYSTGE	DEG_Kelch_Keap1_1	0.2222
p.L151F	TCGA-A5-A0G1	UCEC	TCGA	DYSTGE	DEG_Kelch_Keap1_1	0.1944
p.L151F	DO42472	UCEC	ICGC	DYSTGE	DEG_Kelch_Keap1_1	0.1944
p.S152F	TCGA-D3-A8GI	SKCM	TCGA	DYSTGE	DEG_Kelch_Keap1_1	0.1667
p.S152F	DO50284	SKCM	ICGC	DYSTGE	DEG_Kelch_Keap1_1	0.1667
p.Q153H	TCGA-DU-7294	LGG	TCGA	DYSTGE	DEG_Kelch_Keap1_1	0.1389
p.Q153H	TCGA-XF-AAMZ	BLCA	TCGA	DYSTGE	DEG_Kelch_Keap1_1	0.1389
p.Q153H	DO219051	BLCA	ICGC	DYSTGE	DEG_Kelch_Keap1_1	0.1389
p.Q153H	DO22333	LGG	ICGC	DYSTGE	DEG_Kelch_Keap1_1	0.1389
p.Q153K	TCGA-FY-A3BL	THCA	TCGA	DYSTGE	DEG_Kelch_Keap1_1	0.1389
p.Q153K	DO40190	THCA	ICGC	DYSTGE	DEG_Kelch_Keap1_1	0.1389
p.R134H	DO51634	CESC	ICGC	DYSTGE	DEG_Kelch_Keap1_1	0.1389
p.R134H	DO27184	LUSC	ICGC	DYSTGE	DEG_Kelch_Keap1_1	0.1389
p.R134H	DO37146	READ	ICGC	DYSTGE	DEG_Kelch_Keap1_1	0.1389
p.R134H	DO48173	UCEC	ICGC	DYSTGE	DEG_Kelch_Keap1_1	0.1389
p.Q142H	DO9002	COAD	ICGC	DYSTGE	DEG_Kelch_Keap1_1	0.7582
p.G140S	DO7781	COAD	ICGC	DYSTGE	DEG_Kelch_Keap1_1	0.3056
p.G140S	DO7804	COAD	ICGC	DYSTGE	DEG_Kelch_Keap1_1	0.3056
p.G140S	SIMA	autonomic_ganglia	COSMIC	DYSTGE	DEG_Kelch_Keap1_1	0.3056
p.A146V	DO9756	COAD	ICGC	DYSTGE	DEG_Kelch_Keap1_1	0.6936
p.A146V	DO219138	LUSC	ICGC	DYSTGE	DEG_Kelch_Keap1_1	0.6936
p.A146V	DO27835	MALY	ICGC	DYSTGE	DEG_Kelch_Keap1_1	0.6936
p.Q142E	DO49067	HNSC	ICGC	DYSTGE	DEG_Kelch_Keap1_1	0.6744
p.Q150H	DO14654	HNSC	ICGC	DYSTGE	DEG_Kelch_Keap1_1	0.2222
p.H139Q	DO14173	HNSC	ICGC	DYSTGE	DEG_Kelch_Keap1_1	0.2778
p.A152V	DO45402	LUAD	ICGC	DYSTGE	DEG_Kelch_Keap1_1	0.1667
p.G136C	DO23604	LUAD	ICGC	DYSTGE	DEG_Kelch_Keap1_1	0.1944
p.Y154C	DO23597	LUAD	ICGC	DYSTGE	DEG_Kelch_Keap1_1	0.1111
p.G136V	DO26052	LUAD	ICGC	DYSTGE	DEG_Kelch_Keap1_1	0.1944
p.A145T	DO45494	LUSC	ICGC	DYSTGE	DEG_Kelch_Keap1_1	0.7139
p.A147S	DO45442	LUSC	ICGC	DYSTGE	DEG_Kelch_Keap1_1	0.3056
p.T148A	DO36556	READ	ICGC	DYSTGE	DEG_Kelch_Keap1_1	0.2778
p.G140D	DO218863	SKCA	ICGC	DYSTGE	DEG_Kelch_Keap1_1	0.3056
p.A147V	DO223907	SKCM	ICGC	DYSTGE	DEG_Kelch_Keap1_1	0.3056
p.A156T	DO47757	STAD	ICGC	DYSTGE	DEG_Kelch_Keap1_1	0.0556
p.Q153L	DO229221	THCA	ICGC	DYSTGE	DEG_Kelch_Keap1_1	0.1389
p.R134C	DO42201	UCEC	ICGC	DYSTGE	DEG_Kelch_Keap1_1	0.1389
p.L150R	SIDM00302	Other Solid Cancers	GDSC	DYSTGE	DEG_Kelch_Keap1_1	0.2222
p.L150R	ACH-002149	Ovarian Cancer	CCLE	DYSTGE	DEG_Kelch_Keap1_1	0.2222
p.L150R	KGN	ovary	COSMIC	DYSTGE	DEG_Kelch_Keap1_1	0.2222
p.A146T	MDA-MB-157	breast	COSMIC	DYSTGE	DEG_Kelch_Keap1_1	0.7139
p.S155F	Mewo	skin	COSMIC	DYSTGE	DEG_Kelch_Keap1_1	0.0833
p.P131L	NCI-H520	lung	COSMIC	DYSTGE	DEG_Kelch_Keap1_1	0.0556
p.N143K	NCI-H2066	lung	COSMIC	DYSTGE	DEG_Kelch_Keap1_1	0.6918

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: DYSTGE

Degron related mutations and impact score

Drug responses associated with CTNND2 mutations

All proteins holding degron of DYSTGE

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UQB3	Catenin delta-2	DEG_Kelch_Keap1_1	141:146	DYSTGE	KEAP1	0.836	More...