DegronMD

Uniprot ID: Q76L83

Source protein: Putative Polycomb group protein ASXL2

Source gene: ASXL2

Class: DEG_SCF_FBW7_1

Location: 779:786

E3 ligase: FBXW7

DEGRON score: 0.8891

ASA_SCORE: 92.7875

COIL: 0.9694

CONS_SCORE: 0.3417

DSS_SCORE: 0.6611

HELIX: 0.0129

FCONS_SCORE: 0.9231

RIG_SCORE: 0.6024

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A796S	TCGA-43-2581	LUSC	TCGA	VPPTPAVS	DEG_SCF_FBW7_1	0.0556
p.A796S	DO26602	LUSC	ICGC	VPPTPAVS	DEG_SCF_FBW7_1	0.0556
p.V785I	DO234170	ESAD	ICGC	VPPTPAVS	DEG_SCF_FBW7_1	0.5965
p.V785I	SIDM00217	Colorectal Carcinoma	GDSC	VPPTPAVS	DEG_SCF_FBW7_1	0.5965
p.P795A	DO233853	GACA	ICGC	VPPTPAVS	DEG_SCF_FBW7_1	0.0833
p.D774G	COLO-783	skin	COSMIC	VPPTPAVS	DEG_SCF_FBW7_1	0.1944
p.P792L	SK-NEP-1	kidney	COSMIC	VPPTPAVS	DEG_SCF_FBW7_1	0.1667
p.P780L	HCC202	breast	COSMIC	VPPTPAVS	DEG_SCF_FBW7_1	0.6471

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q76L83	Putative Polycomb group protein ASXL2	DEG_SCF_FBW7_1	779:786	VPPTPAVS	FBXW7	0.8891	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons