DegronMD - Q5VWI1(TCERG1L)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P122Q	TCGA-18-3409	LUSC	TCGA	PPSST	DEG_SPOP_SBC_1	127:131	Mutation rewiring degron network	0.1944
p.P122Q	DO26444	LUSC	ICGC	PPSST	DEG_SPOP_SBC_1	127:131	Mutation rewiring degron network	0.1944
p.P122S	TCGA-18-3409	LUSC	TCGA	PPSST	DEG_SPOP_SBC_1	127:131	Mutation rewiring degron network	0.1944
p.P122S	TCGA-EE-A2M6	SKCM	TCGA	PPSST	DEG_SPOP_SBC_1	127:131	Mutation rewiring degron network	0.1944
p.P122S	DO26444	LUSC	ICGC	PPSST	DEG_SPOP_SBC_1	127:131	Mutation rewiring degron network	0.1944
p.P122S	DO222514	MELA	ICGC	PPSST	DEG_SPOP_SBC_1	127:131	Mutation rewiring degron network	0.1944
p.P122S	DO37976	SKCM	ICGC	PPSST	DEG_SPOP_SBC_1	127:131	Mutation rewiring degron network	0.1944
p.T131A	TCGA-55-8505	LUAD	TCGA	PPSST	DEG_SPOP_SBC_1	127:131	Mutation altering degron motif	0.7139
p.T131A	DO45380	LUAD	ICGC	PPSST	DEG_SPOP_SBC_1	127:131	Mutation altering degron motif	0.7139
p.G118S	TCGA-85-8355	LUSC	TCGA	PPSST	DEG_SPOP_SBC_1	127:131	Mutation rewiring degron network	0.0833
p.G118S	DO45488	LUSC	ICGC	PPSST	DEG_SPOP_SBC_1	127:131	Mutation rewiring degron network	0.0833
p.R583W	TCGA-A5-A2K5	UCEC	TCGA	KMR	DEG_APCC_TPR_1	584:586	Mutation rewiring degron network	0.3056
p.R583W	DO41379	UCEC	ICGC	KMR	DEG_APCC_TPR_1	584:586	Mutation rewiring degron network	0.3056
p.G125V	TCGA-AG-A00Y	READ	TCGA	PPSST	DEG_SPOP_SBC_1	127:131	Mutation rewiring degron network	0.2778
p.G125V	DO36542	READ	ICGC	PPSST	DEG_SPOP_SBC_1	127:131	Mutation rewiring degron network	0.2778
p.R583Q	TCGA-AP-A0LM	UCEC	TCGA	KMR	DEG_APCC_TPR_1	584:586	Mutation rewiring degron network	0.3056
p.R583Q	DO43306	UCEC	ICGC	KMR	DEG_APCC_TPR_1	584:586	Mutation rewiring degron network	0.3056
p.E577D	TCGA-AX-A0J0	UCEC	TCGA	KMR	DEG_APCC_TPR_1	584:586	Mutation rewiring degron network	0.1389
p.E577D	TCGA-AX-A2HC	UCEC	TCGA	KMR	DEG_APCC_TPR_1	584:586	Mutation rewiring degron network	0.1389
p.E577D	DO41572	UCEC	ICGC	KMR	DEG_APCC_TPR_1	584:586	Mutation rewiring degron network	0.1389
p.E577D	DO41133	UCEC	ICGC	KMR	DEG_APCC_TPR_1	584:586	Mutation rewiring degron network	0.1389
p.G118C	TCGA-D3-A2JC	SKCM	TCGA	PPSST	DEG_SPOP_SBC_1	127:131	Mutation rewiring degron network	0.0833
p.G118C	DO47578	SKCM	ICGC	PPSST	DEG_SPOP_SBC_1	127:131	Mutation rewiring degron network	0.0833
p.P128R	TCGA-ER-A19W	SKCM	TCGA	PPSST	DEG_SPOP_SBC_1	127:131	Mutation altering degron motif	0.6401
p.P128R	DO50300	SKCM	ICGC	PPSST	DEG_SPOP_SBC_1	127:131	Mutation altering degron motif	0.6401
p.P128S	TCGA-FR-A726	SKCM	TCGA	PPSST	DEG_SPOP_SBC_1	127:131	Mutation altering degron motif	0.5641
p.P128S	DO48665	SKCM	ICGC	PPSST	DEG_SPOP_SBC_1	127:131	Mutation altering degron motif	0.5641
p.K584N	TCGA-IB-7651	PAAD	TCGA	KMR	DEG_APCC_TPR_1	584:586	Mutation altering degron motif	0.5806
p.K584N	DO46657	PAAD	ICGC	KMR	DEG_APCC_TPR_1	584:586	Mutation altering degron motif	0.5806
p.S129A	DO222712	BTCA	ICGC	PPSST	DEG_SPOP_SBC_1	127:131	Mutation altering degron motif	0.7588
p.P136L	DO233271	GACA	ICGC	PPSST	DEG_SPOP_SBC_1	127:131	Mutation rewiring degron network	0.1944
p.L141I	DO229041	LICA	ICGC	PPSST	DEG_SPOP_SBC_1	127:131	Mutation rewiring degron network	0.0556
p.D575H	DO230535	LUSC	ICGC	KMR	DEG_APCC_TPR_1	584:586	Mutation rewiring degron network	0.0833
p.D575N	DO35210	PACA	ICGC	KMR	DEG_APCC_TPR_1	584:586	Mutation rewiring degron network	0.0833
p.P122L	DO51466	PACA	ICGC	PPSST	DEG_SPOP_SBC_1	127:131	Mutation rewiring degron network	0.1944
p.G118V	DO227531	PACA	ICGC	PPSST	DEG_SPOP_SBC_1	127:131	Mutation rewiring degron network	0.0833
p.E577K	SIDM01945	Colorectal Carcinoma	GDSC	KMR	DEG_APCC_TPR_1	584:586	Mutation rewiring degron network	0.1389
p.R574W	SIDM00216	Colorectal Carcinoma	GDSC	KMR	DEG_APCC_TPR_1	584:586	Mutation rewiring degron network	0.0556
p.R574W	ACH-000989	Colon/Colorectal Cancer	CCLE	KMR	DEG_APCC_TPR_1	584:586	Mutation rewiring degron network	0.0556
p.R574W	SNU-175	large intestine	COSMIC	KMR	DEG_APCC_TPR_1	584:586	Mutation rewiring degron network	0.0556
p.S123F	SIDM00769	Non-Small Cell Lung Carcinoma	GDSC	PPSST	DEG_SPOP_SBC_1	127:131	Mutation rewiring degron network	0.2222
p.S123F	ACH-000733	Lung Cancer	CCLE	PPSST	DEG_SPOP_SBC_1	127:131	Mutation rewiring degron network	0.2222
p.S123F	NCI-H1838	lung	COSMIC	PPSST	DEG_SPOP_SBC_1	127:131	Mutation rewiring degron network	0.2222
p.L126P	SIDM01045	Endometrial Carcinoma	GDSC	PPSST	DEG_SPOP_SBC_1	127:131	Mutation rewiring degron network	0.3056
p.L126P	ACH-000978	Endometrial/Uterine Cancer	CCLE	PPSST	DEG_SPOP_SBC_1	127:131	Mutation rewiring degron network	0.3056
p.L126P	EN	endometrium	COSMIC	PPSST	DEG_SPOP_SBC_1	127:131	Mutation rewiring degron network	0.3056
p.P128T	SIDM00516	Melanoma	GDSC	PPSST	DEG_SPOP_SBC_1	127:131	Mutation altering degron motif	0.5919
p.P128T	SIDM01879	Non-Cancerous	GDSC	PPSST	DEG_SPOP_SBC_1	127:131	Mutation altering degron motif	0.5919
p.E133Q	SIDM00743	Non-Small Cell Lung Carcinoma	GDSC	PPSST	DEG_SPOP_SBC_1	127:131	Mutation rewiring degron network	0.2778
p.S121A	ACH-001853	Bile Duct Cancer	CCLE	PPSST	DEG_SPOP_SBC_1	127:131	Mutation rewiring degron network	0.1667

DegronMD: protein-targeted degradation, mutation and drug response to degrons

TCERG1L

UniProt ID: Q5VWI1

Entrez ID: 256536

Protein name: Transcription elongation regulator 1-like protein

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for TCERG1L in