DegronMD

Uniprot ID: Q5VWI1

Source protein: Transcription elongation regulator 1-like protein

Source gene: TCERG1L

Class: DEG_APCC_TPR_1

Location: 584:586

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.689

ASA_SCORE: 164.8667

COIL: 0.8167

CONS_SCORE: 0.5129

DSS_SCORE: 0.8621

HELIX: 0.196

FCONS_SCORE: 0.947

RIG_SCORE: 0.7864

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R583W	TCGA-A5-A2K5	UCEC	TCGA	KMR	DEG_APCC_TPR_1	0.3056
p.R583W	DO41379	UCEC	ICGC	KMR	DEG_APCC_TPR_1	0.3056
p.R583Q	TCGA-AP-A0LM	UCEC	TCGA	KMR	DEG_APCC_TPR_1	0.3056
p.R583Q	DO43306	UCEC	ICGC	KMR	DEG_APCC_TPR_1	0.3056
p.E577D	TCGA-AX-A0J0	UCEC	TCGA	KMR	DEG_APCC_TPR_1	0.1389
p.E577D	TCGA-AX-A2HC	UCEC	TCGA	KMR	DEG_APCC_TPR_1	0.1389
p.E577D	DO41572	UCEC	ICGC	KMR	DEG_APCC_TPR_1	0.1389
p.E577D	DO41133	UCEC	ICGC	KMR	DEG_APCC_TPR_1	0.1389
p.K584N	TCGA-IB-7651	PAAD	TCGA	KMR	DEG_APCC_TPR_1	0.5806
p.K584N	DO46657	PAAD	ICGC	KMR	DEG_APCC_TPR_1	0.5806
p.D575H	DO230535	LUSC	ICGC	KMR	DEG_APCC_TPR_1	0.0833
p.D575N	DO35210	PACA	ICGC	KMR	DEG_APCC_TPR_1	0.0833
p.E577K	SIDM01945	Colorectal Carcinoma	GDSC	KMR	DEG_APCC_TPR_1	0.1389
p.R574W	SIDM00216	Colorectal Carcinoma	GDSC	KMR	DEG_APCC_TPR_1	0.0556
p.R574W	ACH-000989	Colon/Colorectal Cancer	CCLE	KMR	DEG_APCC_TPR_1	0.0556
p.R574W	SNU-175	large_intestine	COSMIC	KMR	DEG_APCC_TPR_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NR22	Protein arginine N-methyltransferase 8	DEG_APCC_TPR_1	392:394	KMR	APC,CDC20,FZR1	0.5472	More...
Q5VWI1	Transcription elongation regulator 1-like protein	DEG_APCC_TPR_1	584:586	KMR	APC,CDC20,FZR1	0.689	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons