DegronMD

Uniprot ID: Q9NR22

Source protein: Protein arginine N-methyltransferase 8

Source gene: PRMT8

Class: DEG_APCC_TPR_1

Location: 392:394

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5472

ASA_SCORE: 134.3333

COIL: 0.8743

CONS_SCORE: 0.3393

DSS_SCORE: 0.8026

HELIX: 0.006

FCONS_SCORE: 1.169

RIG_SCORE: 0.7896

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R394C	TCGA-4X-A9FC	THYM	TCGA	KMR	DEG_APCC_TPR_1	0.8301
p.R394C	TCGA-AG-3891	READ	TCGA	KMR	DEG_APCC_TPR_1	0.8301
p.R394C	TCGA-BH-A0DI	BRCA	TCGA	KMR	DEG_APCC_TPR_1	0.8301
p.L382M	TCGA-AP-A059	UCEC	TCGA	KMR	DEG_APCC_TPR_1	0.0556
p.E384K	TCGA-ER-A19F	SKCM	TCGA	KMR	DEG_APCC_TPR_1	0.1111
p.D390G	TCGA-F7-A624	HNSC	TCGA	KMR	DEG_APCC_TPR_1	0.2778
p.S388F	TCGA-T3-A92M	HNSC	TCGA	KMR	DEG_APCC_TPR_1	0.2222
p.R385C	DO2281	BRCA	ICGC	KMR	DEG_APCC_TPR_1	0.1389
p.R385C	DO51527	PACA	ICGC	KMR	DEG_APCC_TPR_1	0.1389
p.R385C	DO36388	READ	ICGC	KMR	DEG_APCC_TPR_1	0.1389
p.R394H	SIDM00099	Mesothelioma	GDSC	KMR	DEG_APCC_TPR_1	0.8244
p.R394H	ACH-002128	Lung Cancer	CCLE	KMR	DEG_APCC_TPR_1	0.8244
p.R394H	H2722	pleura	COSMIC	KMR	DEG_APCC_TPR_1	0.8244
p.R385H	H2722	pleura	COSMIC	KMR	DEG_APCC_TPR_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NR22	Protein arginine N-methyltransferase 8	DEG_APCC_TPR_1	392:394	KMR	APC,CDC20,FZR1	0.5472	More...
Q5VWI1	Transcription elongation regulator 1-like protein	DEG_APCC_TPR_1	584:586	KMR	APC,CDC20,FZR1	0.689	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons