DegronMD - Q76G19(PDZD4)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R282Q	TCGA-5M-AAT6	COAD	TCGA	DSGVGRT	DEG_SCF_TRCP1_1	277:283	Mutation altering degron motif	0.6218
p.R282Q	DO223703	COAD	ICGC	DSGVGRT	DEG_SCF_TRCP1_1	277:283	Mutation altering degron motif	0.6218
p.D284E	TCGA-66-2786	LUSC	TCGA	DSGVGRT	DEG_SCF_TRCP1_1	277:283	Mutation rewiring degron network	0.3056
p.D284E	DO26419	LUSC	ICGC	DSGVGRT	DEG_SCF_TRCP1_1	277:283	Mutation rewiring degron network	0.3056
p.P303Q	TCGA-85-6561	LUSC	TCGA	PPSST	DEG_SPOP_SBC_1	302:306	Mutation altering degron motif	0.5924
p.P303Q	DO26518	LUSC	ICGC	PPSST	DEG_SPOP_SBC_1	302:306	Mutation altering degron motif	0.5924
p.E290K	TCGA-AA-3984	COAD	TCGA	DSGVGRT	DEG_SCF_TRCP1_1	277:283	Mutation rewiring degron network	0.1389
p.E290K	TCGA-AA-A00N	COAD	TCGA	DSGVGRT	DEG_SCF_TRCP1_1	277:283	Mutation rewiring degron network	0.1389
p.E290K	TCGA-BS-A0UF	UCEC	TCGA	DSGVGRT	DEG_SCF_TRCP1_1	277:283	Mutation rewiring degron network	0.1389
p.E290K	TCGA-EE-A3AF	SKCM	TCGA	DSGVGRT	DEG_SCF_TRCP1_1	277:283	Mutation rewiring degron network	0.1389
p.E290K	DO9002	COAD	ICGC	DSGVGRT	DEG_SCF_TRCP1_1	277:283	Mutation rewiring degron network	0.1389
p.E290K	DO9876	COAD	ICGC	DSGVGRT	DEG_SCF_TRCP1_1	277:283	Mutation rewiring degron network	0.1389
p.E290K	DO228017	SKCA	ICGC	DSGVGRT	DEG_SCF_TRCP1_1	277:283	Mutation rewiring degron network	0.1389
p.E290K	DO37911	SKCM	ICGC	DSGVGRT	DEG_SCF_TRCP1_1	277:283	Mutation rewiring degron network	0.1389
p.E290K	DO41488	UCEC	ICGC	DSGVGRT	DEG_SCF_TRCP1_1	277:283	Mutation rewiring degron network	0.1389
p.I76T	TCGA-AP-A1DK	UCEC	TCGA	DSGTQT	DEG_SCF_TRCP1_1	69:74	Mutation rewiring degron network	0.2778
p.I76T	DO42033	UCEC	ICGC	DSGTQT	DEG_SCF_TRCP1_1	69:74	Mutation rewiring degron network	0.2778
p.D75N	TCGA-AP-A1E0	UCEC	TCGA	DSGTQT	DEG_SCF_TRCP1_1	69:74	Mutation rewiring degron network	0.3056
p.D75N	DO43154	UCEC	ICGC	DSGTQT	DEG_SCF_TRCP1_1	69:74	Mutation rewiring degron network	0.3056
p.D75N	SIDM00118	Colorectal Carcinoma	GDSC	DSGTQT	DEG_SCF_TRCP1_1	69:74	Mutation rewiring degron network	0.3056
p.D75N	ACH-001081	Colon/Colorectal Cancer	CCLE	DSGTQT	DEG_SCF_TRCP1_1	69:74	Mutation rewiring degron network	0.3056
p.D75N	HCC2998	large intestine	COSMIC	DSGTQT	DEG_SCF_TRCP1_1	69:74	Mutation rewiring degron network	0.3056
p.A83V	TCGA-BH-A18G	BRCA	TCGA	DSGTQT	DEG_SCF_TRCP1_1	69:74	Mutation rewiring degron network	0.0833
p.A83V	DO3686	BRCA	ICGC	DSGTQT	DEG_SCF_TRCP1_1	69:74	Mutation rewiring degron network	0.0833
p.A83V	DO228435	MALY	ICGC	DSGTQT	DEG_SCF_TRCP1_1	69:74	Mutation rewiring degron network	0.0833
p.D59E	TCGA-BH-A201	BRCA	TCGA	DSGTQT	DEG_SCF_TRCP1_1	69:74	Mutation rewiring degron network	0.0556
p.D59E	DO2192	BRCA	ICGC	DSGTQT	DEG_SCF_TRCP1_1	69:74	Mutation rewiring degron network	0.0556
p.R313C	TCGA-BK-A6W3	UCEC	TCGA	PPSST	DEG_SPOP_SBC_1	302:306	Mutation rewiring degron network	0.1389
p.R313C	DO50076	UCEC	ICGC	PPSST	DEG_SPOP_SBC_1	302:306	Mutation rewiring degron network	0.1389
p.G299V	TCGA-BQ-7049	KIRP	TCGA	PPSST	DEG_SPOP_SBC_1	302:306	Mutation rewiring degron network	0.25
p.G299V	DO20853	KIRP	ICGC	PPSST	DEG_SPOP_SBC_1	302:306	Mutation rewiring degron network	0.25
p.S311R	TCGA-DX-A6YS	SARC	TCGA	PPSST	DEG_SPOP_SBC_1	302:306	Mutation rewiring degron network	0.1944
p.S311R	DO229045	LICA	ICGC	PPSST	DEG_SPOP_SBC_1	302:306	Mutation rewiring degron network	0.1944
p.S311R	DO220005	SARC	ICGC	PPSST	DEG_SPOP_SBC_1	302:306	Mutation rewiring degron network	0.1944
p.E79K	TCGA-EB-A430	SKCM	TCGA	DSGTQT	DEG_SCF_TRCP1_1	69:74	Mutation rewiring degron network	0.1944
p.E79K	DO37906	SKCM	ICGC	DSGTQT	DEG_SCF_TRCP1_1	69:74	Mutation rewiring degron network	0.1944
p.E301K	TCGA-EE-A2MF	SKCM	TCGA	PPSST	DEG_SPOP_SBC_1	302:306	Mutation rewiring degron network	0.3056
p.E301K	DO222491	MELA	ICGC	PPSST	DEG_SPOP_SBC_1	302:306	Mutation rewiring degron network	0.3056
p.E301K	DO51249	SKCM	ICGC	PPSST	DEG_SPOP_SBC_1	302:306	Mutation rewiring degron network	0.3056
p.Q73E	DO228471	BRCA	ICGC	DSGTQT	DEG_SCF_TRCP1_1	69:74	Mutation altering degron motif	0.5633
p.D284N	DO223058	ESCA	ICGC	DSGVGRT	DEG_SCF_TRCP1_1	277:283	Mutation rewiring degron network	0.3056
p.S292R	DO228952	LICA	ICGC	DSGVGRT	DEG_SCF_TRCP1_1	277:283	Mutation rewiring degron network	0.0833
p.S292R	DO228952	LICA	ICGC	PPSST	DEG_SPOP_SBC_1	302:306	Mutation rewiring degron network	0.0556
p.S304R	DO228976	LICA	ICGC	PPSST	DEG_SPOP_SBC_1	302:306	Mutation altering degron motif	0.7427
p.D277E	DO228985	LICA	ICGC	DSGVGRT	DEG_SCF_TRCP1_1	277:283	Mutation altering degron motif	0.6758
p.S273R	DO229018	LICA	ICGC	DSGVGRT	DEG_SCF_TRCP1_1	277:283	Mutation rewiring degron network	0.2222
p.L270M	DO229028	LICA	ICGC	DSGVGRT	DEG_SCF_TRCP1_1	277:283	Mutation rewiring degron network	0.1389
p.G299E	DO42673	UCEC	ICGC	PPSST	DEG_SPOP_SBC_1	302:306	Mutation rewiring degron network	0.25
p.G285R	SIDM00121	T-Lymphoblastic Leukemia	GDSC	DSGVGRT	DEG_SCF_TRCP1_1	277:283	Mutation rewiring degron network	0.2778
p.G285R	CCRF-CEM	haematopoietic and lymphoid tissue	COSMIC	DSGVGRT	DEG_SCF_TRCP1_1	277:283	Mutation rewiring degron network	0.2778
p.D69G	SIDM01588	Endometrial Carcinoma	GDSC	DSGTQT	DEG_SCF_TRCP1_1	69:74	Mutation altering degron motif	0.7198
p.D69G	ACH-000993	Endometrial/Uterine Cancer	CCLE	DSGTQT	DEG_SCF_TRCP1_1	69:74	Mutation altering degron motif	0.7198
p.R282L	ACH-000737	Lung Cancer	CCLE	DSGVGRT	DEG_SCF_TRCP1_1	277:283	Mutation altering degron motif	0.7316
p.G279R	ACH-001738	Leukemia	CCLE	DSGVGRT	DEG_SCF_TRCP1_1	277:283	Mutation altering degron motif	0.7568
p.G279R	CCRF-CEM	haematopoietic and lymphoid tissue	COSMIC	DSGVGRT	DEG_SCF_TRCP1_1	277:283	Mutation altering degron motif	0.7568
p.D277G	ACH-001991	Primary	CCLE	DSGVGRT	DEG_SCF_TRCP1_1	277:283	Mutation altering degron motif	0.7198
p.R309W	SNG-M	endometrium	COSMIC	PPSST	DEG_SPOP_SBC_1	302:306	Mutation rewiring degron network	0.25
p.R270L	NCI-H2009	lung	COSMIC	DSGVGRT	DEG_SCF_TRCP1_1	277:283	Mutation rewiring degron network	0.1389
p.E296K	451Lu	skin	COSMIC	PPSST	DEG_SPOP_SBC_1	302:306	Mutation rewiring degron network	0.1667
p.A60T	NUGC-3	stomach	COSMIC	DSGTQT	DEG_SCF_TRCP1_1	69:74	Mutation rewiring degron network	0.0833

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PDZD4

UniProt ID: Q76G19

Entrez ID: 57595

Protein name: PDZ domain-containing protein 4 (PDZ domain-containing RING finger protein 4-like protein)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PDZD4 in