DegronMD

Uniprot ID: Q76G19

Source protein: PDZ domain-containing protein 4

Source gene: PDZD4

Class: DEG_SCF_TRCP1_1

Location: 277:283

E3 ligase: BTRC

DEGRON score: 0.9927

ASA_SCORE: 71.2714

COIL: 0.8011

CONS_SCORE: 0.5465

DSS_SCORE: 0.824

HELIX: 0.059

FCONS_SCORE: 1.2075

RIG_SCORE: 0.5754

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R282Q	TCGA-5M-AAT6	COAD	TCGA	DSGVGRT	DEG_SCF_TRCP1_1	0.6218
p.R282Q	DO223703	COAD	ICGC	DSGVGRT	DEG_SCF_TRCP1_1	0.6218
p.D284E	TCGA-66-2786	LUSC	TCGA	DSGVGRT	DEG_SCF_TRCP1_1	0.3056
p.D284E	DO26419	LUSC	ICGC	DSGVGRT	DEG_SCF_TRCP1_1	0.3056
p.E290K	TCGA-AA-3984	COAD	TCGA	DSGVGRT	DEG_SCF_TRCP1_1	0.1389
p.E290K	TCGA-AA-A00N	COAD	TCGA	DSGVGRT	DEG_SCF_TRCP1_1	0.1389
p.E290K	TCGA-BS-A0UF	UCEC	TCGA	DSGVGRT	DEG_SCF_TRCP1_1	0.1389
p.E290K	TCGA-EE-A3AF	SKCM	TCGA	DSGVGRT	DEG_SCF_TRCP1_1	0.1389
p.E290K	DO9002	COAD	ICGC	DSGVGRT	DEG_SCF_TRCP1_1	0.1389
p.E290K	DO9876	COAD	ICGC	DSGVGRT	DEG_SCF_TRCP1_1	0.1389
p.E290K	DO228017	SKCA	ICGC	DSGVGRT	DEG_SCF_TRCP1_1	0.1389
p.E290K	DO37911	SKCM	ICGC	DSGVGRT	DEG_SCF_TRCP1_1	0.1389
p.E290K	DO41488	UCEC	ICGC	DSGVGRT	DEG_SCF_TRCP1_1	0.1389
p.D284N	DO223058	ESCA	ICGC	DSGVGRT	DEG_SCF_TRCP1_1	0.3056
p.S292R	DO228952	LICA	ICGC	DSGVGRT	DEG_SCF_TRCP1_1	0.0833
p.D277E	DO228985	LICA	ICGC	DSGVGRT	DEG_SCF_TRCP1_1	0.6758
p.S273R	DO229018	LICA	ICGC	DSGVGRT	DEG_SCF_TRCP1_1	0.2222
p.L270M	DO229028	LICA	ICGC	DSGVGRT	DEG_SCF_TRCP1_1	0.1389
p.G285R	SIDM00121	T-Lymphoblastic Leukemia	GDSC	DSGVGRT	DEG_SCF_TRCP1_1	0.2778
p.G285R	CCRF-CEM	haematopoietic_and_lymphoid_tissue	COSMIC	DSGVGRT	DEG_SCF_TRCP1_1	0.2778
p.R282L	ACH-000737	Lung Cancer	CCLE	DSGVGRT	DEG_SCF_TRCP1_1	0.7316
p.G279R	ACH-001738	Leukemia	CCLE	DSGVGRT	DEG_SCF_TRCP1_1	0.7568
p.G279R	CCRF-CEM	haematopoietic_and_lymphoid_tissue	COSMIC	DSGVGRT	DEG_SCF_TRCP1_1	0.7568
p.D277G	ACH-001991	Primary	CCLE	DSGVGRT	DEG_SCF_TRCP1_1	0.7198
p.R270L	NCI-H2009	lung	COSMIC	DSGVGRT	DEG_SCF_TRCP1_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UPQ7	E3 ubiquitin-protein ligase PDZRN3	DEG_SCF_TRCP1_1	568:574	DSGVGRT	BTRC	0.993	More...
Q6ZMN7	PDZ domain-containing RING finger protein 4	DEG_SCF_TRCP1_1	552:558	DSGVGRT	BTRC	0.9956	More...
Q76G19	PDZ domain-containing protein 4	DEG_SCF_TRCP1_1	277:283	DSGVGRT	BTRC	0.9927	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons