DegronMD - Q6ZMN7(PDZRN4)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.T539K	TCGA-55-8207	LUAD	TCGA	ATSSS	DEG_SPOP_SBC_1	542:546	Mutation rewiring degron network	0.25
p.T539K	DO45351	LUAD	ICGC	ATSSS	DEG_SPOP_SBC_1	542:546	Mutation rewiring degron network	0.25
p.E536K	TCGA-A5-A1OF	UCEC	TCGA	ATSSS	DEG_SPOP_SBC_1	542:546	Mutation rewiring degron network	0.1667
p.E536K	DO42568	UCEC	ICGC	ATSSS	DEG_SPOP_SBC_1	542:546	Mutation rewiring degron network	0.1667
p.R563Q	TCGA-AA-3510	COAD	TCGA	DSGVGRT	DEG_SCF_TRCP1_1	552:558	Mutation rewiring degron network	0.1944
p.R563Q	TCGA-AA-A00N	COAD	TCGA	DSGVGRT	DEG_SCF_TRCP1_1	552:558	Mutation rewiring degron network	0.1944
p.R563Q	TCGA-AA-A010	COAD	TCGA	DSGVGRT	DEG_SCF_TRCP1_1	552:558	Mutation rewiring degron network	0.1944
p.R563Q	TCGA-AJ-A3EL	UCEC	TCGA	DSGVGRT	DEG_SCF_TRCP1_1	552:558	Mutation rewiring degron network	0.1944
p.R563Q	TCGA-B5-A11E	UCEC	TCGA	DSGVGRT	DEG_SCF_TRCP1_1	552:558	Mutation rewiring degron network	0.1944
p.R563Q	TCGA-D3-A5GO	SKCM	TCGA	DSGVGRT	DEG_SCF_TRCP1_1	552:558	Mutation rewiring degron network	0.1944
p.R563Q	TCGA-EE-A2MT	SKCM	TCGA	DSGVGRT	DEG_SCF_TRCP1_1	552:558	Mutation rewiring degron network	0.1944
p.R563Q	TCGA-GN-A8LK	SKCM	TCGA	DSGVGRT	DEG_SCF_TRCP1_1	552:558	Mutation rewiring degron network	0.1944
p.R563Q	DO225103	BRCA	ICGC	DSGVGRT	DEG_SCF_TRCP1_1	552:558	Mutation rewiring degron network	0.1944
p.R563Q	DO7783	COAD	ICGC	DSGVGRT	DEG_SCF_TRCP1_1	552:558	Mutation rewiring degron network	0.1944
p.R563Q	DO9876	COAD	ICGC	DSGVGRT	DEG_SCF_TRCP1_1	552:558	Mutation rewiring degron network	0.1944
p.R563Q	DO222699	MELA	ICGC	DSGVGRT	DEG_SCF_TRCP1_1	552:558	Mutation rewiring degron network	0.1944
p.R563Q	DO47419	SKCM	ICGC	DSGVGRT	DEG_SCF_TRCP1_1	552:558	Mutation rewiring degron network	0.1944
p.R563Q	DO38051	SKCM	ICGC	DSGVGRT	DEG_SCF_TRCP1_1	552:558	Mutation rewiring degron network	0.1944
p.R563Q	DO51259	SKCM	ICGC	DSGVGRT	DEG_SCF_TRCP1_1	552:558	Mutation rewiring degron network	0.1944
p.R563Q	DO41644	UCEC	ICGC	DSGVGRT	DEG_SCF_TRCP1_1	552:558	Mutation rewiring degron network	0.1944
p.R563Q	DO41542	UCEC	ICGC	DSGVGRT	DEG_SCF_TRCP1_1	552:558	Mutation rewiring degron network	0.1944
p.R563Q	SIDM01611	Endometrial Carcinoma	GDSC	DSGVGRT	DEG_SCF_TRCP1_1	552:558	Mutation rewiring degron network	0.1944
p.R563Q	ACH-000996	Endometrial/Uterine Cancer	CCLE	DSGVGRT	DEG_SCF_TRCP1_1	552:558	Mutation rewiring degron network	0.1944
p.S561I	TCGA-AP-A0LM	UCEC	TCGA	DSGVGRT	DEG_SCF_TRCP1_1	552:558	Mutation rewiring degron network	0.25
p.S561I	DO229027	LICA	ICGC	DSGVGRT	DEG_SCF_TRCP1_1	552:558	Mutation rewiring degron network	0.25
p.S561I	DO43306	UCEC	ICGC	DSGVGRT	DEG_SCF_TRCP1_1	552:558	Mutation rewiring degron network	0.25
p.G554V	TCGA-BS-A0UF	UCEC	TCGA	DSGVGRT	DEG_SCF_TRCP1_1	552:558	Mutation altering degron motif	0.7532
p.G554V	DO41488	UCEC	ICGC	DSGVGRT	DEG_SCF_TRCP1_1	552:558	Mutation altering degron motif	0.7532
p.G537C	TCGA-UF-A7JA	HNSC	TCGA	ATSSS	DEG_SPOP_SBC_1	542:546	Mutation rewiring degron network	0.1944
p.G537C	DO52112	HNSC	ICGC	ATSSS	DEG_SPOP_SBC_1	542:546	Mutation rewiring degron network	0.1944
p.E535D	TCGA-VQ-A8P3	STAD	TCGA	ATSSS	DEG_SPOP_SBC_1	542:546	Mutation rewiring degron network	0.1389
p.E535D	DO51762	STAD	ICGC	ATSSS	DEG_SPOP_SBC_1	542:546	Mutation rewiring degron network	0.1389
p.E560K	TCGA-W3-AA1W	SKCM	TCGA	DSGVGRT	DEG_SCF_TRCP1_1	552:558	Mutation rewiring degron network	0.2778
p.E560K	DO51277	SKCM	ICGC	DSGVGRT	DEG_SCF_TRCP1_1	552:558	Mutation rewiring degron network	0.2778
p.D540H	DO218440	BTCA	ICGC	ATSSS	DEG_SPOP_SBC_1	542:546	Mutation rewiring degron network	0.2778
p.R557C	DO233791	GACA	ICGC	DSGVGRT	DEG_SCF_TRCP1_1	552:558	Mutation altering degron motif	0.719
p.D559E	DO48736	LIRI	ICGC	DSGVGRT	DEG_SCF_TRCP1_1	552:558	Mutation rewiring degron network	0.3056
p.S546Y	DO230990	LUSC	ICGC	ATSSS	DEG_SPOP_SBC_1	542:546	Mutation altering degron motif	0.712
p.S546Y	DO224554	LUSC	ICGC	ATSSS	DEG_SPOP_SBC_1	542:546	Mutation altering degron motif	0.712
p.D565N	DO222390	MELA	ICGC	DSGVGRT	DEG_SCF_TRCP1_1	552:558	Mutation rewiring degron network	0.1389
p.A542E	SIDM01026	Esophageal Squamous Cell Carcinoma	GDSC	ATSSS	DEG_SPOP_SBC_1	542:546	Mutation altering degron motif	0.7701
p.A542E	ACH-000824	Esophageal Cancer	CCLE	ATSSS	DEG_SPOP_SBC_1	542:546	Mutation altering degron motif	0.7701
p.A542E	KYSE-510	oesophagus	COSMIC	ATSSS	DEG_SPOP_SBC_1	542:546	Mutation altering degron motif	0.7701
p.D540Y	SIDM01611	Endometrial Carcinoma	GDSC	ATSSS	DEG_SPOP_SBC_1	542:546	Mutation rewiring degron network	0.2778
p.D540Y	ACH-000996	Endometrial/Uterine Cancer	CCLE	ATSSS	DEG_SPOP_SBC_1	542:546	Mutation rewiring degron network	0.2778
p.S553I	SIDM01782	Oral Cavity Carcinoma	GDSC	DSGVGRT	DEG_SCF_TRCP1_1	552:558	Mutation altering degron motif	0.7341
p.S545L	ACH-000854	Myeloma	CCLE	ATSSS	DEG_SPOP_SBC_1	542:546	Mutation altering degron motif	0.7667

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PDZRN4

UniProt ID: Q6ZMN7

Entrez ID: 29951

Protein name: PDZ domain-containing RING finger protein 4 (Ligand of Numb protein X 4) (SEMACAP3-like protein)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PDZRN4 in