DegronMD

Uniprot ID: Q6ZMN7

Source protein: PDZ domain-containing RING finger protein 4

Source gene: PDZRN4

Class: DEG_SCF_TRCP1_1

Location: 552:558

E3 ligase: BTRC

DEGRON score: 0.9956

ASA_SCORE: 69.2143

COIL: 0.7981

CONS_SCORE: 0.5215

DSS_SCORE: 0.7681

HELIX: 0.069

FCONS_SCORE: 1.1742

RIG_SCORE: 0.5671

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R563Q	TCGA-AA-3510	COAD	TCGA	DSGVGRT	DEG_SCF_TRCP1_1	0.1944
p.R563Q	TCGA-AA-A00N	COAD	TCGA	DSGVGRT	DEG_SCF_TRCP1_1	0.1944
p.R563Q	TCGA-AA-A010	COAD	TCGA	DSGVGRT	DEG_SCF_TRCP1_1	0.1944
p.R563Q	TCGA-AJ-A3EL	UCEC	TCGA	DSGVGRT	DEG_SCF_TRCP1_1	0.1944
p.R563Q	TCGA-B5-A11E	UCEC	TCGA	DSGVGRT	DEG_SCF_TRCP1_1	0.1944
p.R563Q	TCGA-D3-A5GO	SKCM	TCGA	DSGVGRT	DEG_SCF_TRCP1_1	0.1944
p.R563Q	TCGA-EE-A2MT	SKCM	TCGA	DSGVGRT	DEG_SCF_TRCP1_1	0.1944
p.R563Q	TCGA-GN-A8LK	SKCM	TCGA	DSGVGRT	DEG_SCF_TRCP1_1	0.1944
p.R563Q	DO225103	BRCA	ICGC	DSGVGRT	DEG_SCF_TRCP1_1	0.1944
p.R563Q	DO7783	COAD	ICGC	DSGVGRT	DEG_SCF_TRCP1_1	0.1944
p.R563Q	DO9876	COAD	ICGC	DSGVGRT	DEG_SCF_TRCP1_1	0.1944
p.R563Q	DO222699	MELA	ICGC	DSGVGRT	DEG_SCF_TRCP1_1	0.1944
p.R563Q	DO47419	SKCM	ICGC	DSGVGRT	DEG_SCF_TRCP1_1	0.1944
p.R563Q	DO38051	SKCM	ICGC	DSGVGRT	DEG_SCF_TRCP1_1	0.1944
p.R563Q	DO51259	SKCM	ICGC	DSGVGRT	DEG_SCF_TRCP1_1	0.1944
p.R563Q	DO41644	UCEC	ICGC	DSGVGRT	DEG_SCF_TRCP1_1	0.1944
p.R563Q	DO41542	UCEC	ICGC	DSGVGRT	DEG_SCF_TRCP1_1	0.1944
p.R563Q	SIDM01611	Endometrial Carcinoma	GDSC	DSGVGRT	DEG_SCF_TRCP1_1	0.1944
p.R563Q	ACH-000996	Endometrial/Uterine Cancer	CCLE	DSGVGRT	DEG_SCF_TRCP1_1	0.1944
p.S561I	TCGA-AP-A0LM	UCEC	TCGA	DSGVGRT	DEG_SCF_TRCP1_1	0.25
p.S561I	DO229027	LICA	ICGC	DSGVGRT	DEG_SCF_TRCP1_1	0.25
p.S561I	DO43306	UCEC	ICGC	DSGVGRT	DEG_SCF_TRCP1_1	0.25
p.G554V	TCGA-BS-A0UF	UCEC	TCGA	DSGVGRT	DEG_SCF_TRCP1_1	0.7532
p.G554V	DO41488	UCEC	ICGC	DSGVGRT	DEG_SCF_TRCP1_1	0.7532
p.E560K	TCGA-W3-AA1W	SKCM	TCGA	DSGVGRT	DEG_SCF_TRCP1_1	0.2778
p.E560K	DO51277	SKCM	ICGC	DSGVGRT	DEG_SCF_TRCP1_1	0.2778
p.R557C	DO233791	GACA	ICGC	DSGVGRT	DEG_SCF_TRCP1_1	0.719
p.D559E	DO48736	LIRI	ICGC	DSGVGRT	DEG_SCF_TRCP1_1	0.3056
p.D565N	DO222390	MELA	ICGC	DSGVGRT	DEG_SCF_TRCP1_1	0.1389
p.S553I	SIDM01782	Oral Cavity Carcinoma	GDSC	DSGVGRT	DEG_SCF_TRCP1_1	0.7341

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UPQ7	E3 ubiquitin-protein ligase PDZRN3	DEG_SCF_TRCP1_1	568:574	DSGVGRT	BTRC	0.993	More...
Q6ZMN7	PDZ domain-containing RING finger protein 4	DEG_SCF_TRCP1_1	552:558	DSGVGRT	BTRC	0.9956	More...
Q76G19	PDZ domain-containing protein 4	DEG_SCF_TRCP1_1	277:283	DSGVGRT	BTRC	0.9927	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: DSGVGRT

Degron related mutations and impact score

Drug responses associated with PDZRN4 mutations

All proteins holding degron of DSGVGRT