DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
DSGVGRT
Uniprot ID:
Q9UPQ7
Source protein:
E3 ubiquitin-protein ligase PDZRN3
Source gene:
PDZRN3
Class:
DEG_SCF_TRCP1_1
Location:
568:574
E3 ligase:
BTRC
DEGRON score:
0.993
ASA_SCORE:
73.2429
COIL:
0.8591
CONS_SCORE:
0.7349
DSS_SCORE:
0.7447
HELIX:
0.055
FCONS_SCORE:
1.1738
RIG_SCORE:
0.5916
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.E566K
TCGA-58-A46J
LUSC
TCGA
DSGVGRT
DEG_SCF_TRCP1_1
0.2778
p.E566K
DO45532
LUSC
ICGC
DSGVGRT
DEG_SCF_TRCP1_1
0.2778
p.V571E
TCGA-68-8251
LUSC
TCGA
DSGVGRT
DEG_SCF_TRCP1_1
0.6582
p.L561F
TCGA-77-7141
LUSC
TCGA
DSGVGRT
DEG_SCF_TRCP1_1
0.1389
p.L561F
DO26450
LUSC
ICGC
DSGVGRT
DEG_SCF_TRCP1_1
0.1389
p.I560L
TCGA-B5-A3FA
UCEC
TCGA
DSGVGRT
DEG_SCF_TRCP1_1
0.1111
p.S577R
TCGA-CN-4739
HNSC
TCGA
DSGVGRT
DEG_SCF_TRCP1_1
0.25
p.R573Q
TCGA-EJ-7782
PRAD
TCGA
DSGVGRT
DEG_SCF_TRCP1_1
0.6218
p.S583T
DO223000
BTCA
ICGC
DSGVGRT
DEG_SCF_TRCP1_1
0.0833
p.S584P
DO10842
ESAD
ICGC
DSGVGRT
DEG_SCF_TRCP1_1
0.0556
p.G570S
DO234343
ESAD
ICGC
DSGVGRT
DEG_SCF_TRCP1_1
0.6993
p.A558D
DO229041
LICA
ICGC
DSGVGRT
DEG_SCF_TRCP1_1
0.0556
p.S562C
DO48759
LIRI
ICGC
DSGVGRT
DEG_SCF_TRCP1_1
0.1667
p.R583P
DO26052
LUAD
ICGC
DSGVGRT
DEG_SCF_TRCP1_1
0.0833
p.R583C
DO232761
PBCA
ICGC
DSGVGRT
DEG_SCF_TRCP1_1
0.0833
p.T570N
DO41871
UCEC
ICGC
DSGVGRT
DEG_SCF_TRCP1_1
0.7055
p.R575C
DO43811
UCEC
ICGC
DSGVGRT
DEG_SCF_TRCP1_1
0.3056
p.R573W
SIDM02068
Esophageal Carcinoma
GDSC
DSGVGRT
DEG_SCF_TRCP1_1
0.7523
p.E582K
SIDM02021
Esophageal Carcinoma
GDSC
DSGVGRT
DEG_SCF_TRCP1_1
0.1111
p.P566T
ACH-000389
Brain Cancer
CCLE
DSGVGRT
DEG_SCF_TRCP1_1
0.2778
p.P566T
H4
central_nervous_system
COSMIC
DSGVGRT
DEG_SCF_TRCP1_1
0.2778
p.T567M
ACH-000807
Brain Cancer
CCLE
DSGVGRT
DEG_SCF_TRCP1_1
0.3056
p.P566S
ACH-001664
Gastric Cancer
CCLE
DSGVGRT
DEG_SCF_TRCP1_1
0.2778
p.L559P
MHH-PREB-1
haematopoietic_and_lymphoid_tissue
COSMIC
DSGVGRT
DEG_SCF_TRCP1_1
0.0833
Drug responses associated with PDZRN3 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of DSGVGRT
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q9UPQ7
E3 ubiquitin-protein ligase PDZRN3
DEG_SCF_TRCP1_1
568:574
DSGVGRT
BTRC
0.993
More...
Q6ZMN7
PDZ domain-containing RING finger protein 4
DEG_SCF_TRCP1_1
552:558
DSGVGRT
BTRC
0.9956
More...
Q76G19
PDZ domain-containing protein 4
DEG_SCF_TRCP1_1
277:283
DSGVGRT
BTRC
0.9927
More...