DegronMD

Uniprot ID: Q9UPQ7

Source protein: E3 ubiquitin-protein ligase PDZRN3

Source gene: PDZRN3

Class: DEG_SCF_TRCP1_1

Location: 568:574

E3 ligase: BTRC

DEGRON score: 0.993

ASA_SCORE: 73.2429

COIL: 0.8591

CONS_SCORE: 0.7349

DSS_SCORE: 0.7447

HELIX: 0.055

FCONS_SCORE: 1.1738

RIG_SCORE: 0.5916

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R573W	SIDM02068	Esophageal Carcinoma	GDSC	DSGVGRT	DEG_SCF_TRCP1_1	0.7523
p.T570N	DO41871	UCEC	ICGC	DSGVGRT	DEG_SCF_TRCP1_1	0.7055
p.G570S	DO234343	ESAD	ICGC	DSGVGRT	DEG_SCF_TRCP1_1	0.6993
p.V571E	TCGA-68-8251	LUSC	TCGA	DSGVGRT	DEG_SCF_TRCP1_1	0.6582
p.R573Q	TCGA-EJ-7782	PRAD	TCGA	DSGVGRT	DEG_SCF_TRCP1_1	0.6218
p.R575C	DO43811	UCEC	ICGC	DSGVGRT	DEG_SCF_TRCP1_1	0.3056
p.T567M	ACH-000807	Brain Cancer	CCLE	DSGVGRT	DEG_SCF_TRCP1_1	0.3056
p.E566K	TCGA-58-A46J	LUSC	TCGA	DSGVGRT	DEG_SCF_TRCP1_1	0.2778
p.E566K	DO45532	LUSC	ICGC	DSGVGRT	DEG_SCF_TRCP1_1	0.2778
p.P566T	ACH-000389	Brain Cancer	CCLE	DSGVGRT	DEG_SCF_TRCP1_1	0.2778
p.P566T	H4	central_nervous_system	COSMIC	DSGVGRT	DEG_SCF_TRCP1_1	0.2778
p.P566S	ACH-001664	Gastric Cancer	CCLE	DSGVGRT	DEG_SCF_TRCP1_1	0.2778
p.S577R	TCGA-CN-4739	HNSC	TCGA	DSGVGRT	DEG_SCF_TRCP1_1	0.25
p.S562C	DO48759	LIRI	ICGC	DSGVGRT	DEG_SCF_TRCP1_1	0.1667
p.L561F	TCGA-77-7141	LUSC	TCGA	DSGVGRT	DEG_SCF_TRCP1_1	0.1389
p.L561F	DO26450	LUSC	ICGC	DSGVGRT	DEG_SCF_TRCP1_1	0.1389
p.I560L	TCGA-B5-A3FA	UCEC	TCGA	DSGVGRT	DEG_SCF_TRCP1_1	0.1111
p.E582K	SIDM02021	Esophageal Carcinoma	GDSC	DSGVGRT	DEG_SCF_TRCP1_1	0.1111
p.S583T	DO223000	BTCA	ICGC	DSGVGRT	DEG_SCF_TRCP1_1	0.0833
p.R583P	DO26052	LUAD	ICGC	DSGVGRT	DEG_SCF_TRCP1_1	0.0833
p.R583C	DO232761	PBCA	ICGC	DSGVGRT	DEG_SCF_TRCP1_1	0.0833
p.L559P	MHH-PREB-1	haematopoietic_and_lymphoid_tissue	COSMIC	DSGVGRT	DEG_SCF_TRCP1_1	0.0833
p.S584P	DO10842	ESAD	ICGC	DSGVGRT	DEG_SCF_TRCP1_1	0.0556
p.A558D	DO229041	LICA	ICGC	DSGVGRT	DEG_SCF_TRCP1_1	0.0556

Showing 1 to 24 of 24 entries

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UPQ7	E3 ubiquitin-protein ligase PDZRN3	DEG_SCF_TRCP1_1	568:574	DSGVGRT	BTRC	0.993	More...
Q76G19	PDZ domain-containing protein 4	DEG_SCF_TRCP1_1	277:283	DSGVGRT	BTRC	0.9927	More...
Q6ZMN7	PDZ domain-containing RING finger protein 4	DEG_SCF_TRCP1_1	552:558	DSGVGRT	BTRC	0.9956	More...

Showing 1 to 3 of 3 entries

DegronMD: protein-targeted degradation, mutation and drug response to degrons