DegronMD - Q9UPQ7(PDZRN3)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.T812A	TCGA-06-5416	GBM	TCGA	VGTPTYS	DEG_SCF_FBW7_1	817:823	Mutation rewiring degron network	0.1944
p.T812A	DO10880	GBM	ICGC	VGTPTYS	DEG_SCF_FBW7_1	817:823	Mutation rewiring degron network	0.1944
p.D830G	TCGA-17-Z047	LUAD	TCGA	VGTPTYS	DEG_SCF_FBW7_1	817:823	Mutation rewiring degron network	0.1389
p.N730S	TCGA-17-Z049	LUAD	TCGA	RRHELSDIT	DEG_APCC_DBOX_1	736:744	Mutation rewiring degron network	0.1667
p.T821N	TCGA-18-4721	LUSC	TCGA	VGTPTYS	DEG_SCF_FBW7_1	817:823	Mutation altering degron motif	0.5944
p.K827N	TCGA-21-1079	LUSC	TCGA	VGTPTYS	DEG_SCF_FBW7_1	817:823	Mutation substituting flanking lysine	0.3333
p.L336F	TCGA-22-5473	LUSC	TCGA	MFTPPSE	DEG_SCF_FBW7_2	344:350	Mutation rewiring degron network	0.1111
p.L336F	DO26467	LUSC	ICGC	MFTPPSE	DEG_SCF_FBW7_2	344:350	Mutation rewiring degron network	0.1111
p.T819S	TCGA-24-0982	OV	TCGA	VGTPTYS	DEG_SCF_FBW7_1	817:823	Mutation altering degron motif	0.8227
p.L829M	TCGA-44-7661	LUAD	TCGA	VGTPTYS	DEG_SCF_FBW7_1	817:823	Mutation rewiring degron network	0.1667
p.L829M	DO23602	LUAD	ICGC	VGTPTYS	DEG_SCF_FBW7_1	817:823	Mutation rewiring degron network	0.1667
p.G242V	TCGA-44-7667	LUAD	TCGA	LVLHRD	LIG_APCC_ABBA_1	250:255	Mutation rewiring degron network	0.1111
p.G242V	DO23830	LUAD	ICGC	LVLHRD	LIG_APCC_ABBA_1	250:255	Mutation rewiring degron network	0.1111
p.E566K	TCGA-58-A46J	LUSC	TCGA	DSGVGRT	DEG_SCF_TRCP1_1	568:574	Mutation rewiring degron network	0.2778
p.E566K	DO45532	LUSC	ICGC	DSGVGRT	DEG_SCF_TRCP1_1	568:574	Mutation rewiring degron network	0.2778
p.V571E	TCGA-68-8251	LUSC	TCGA	DSGVGRT	DEG_SCF_TRCP1_1	568:574	Mutation altering degron motif	0.6582
p.D734N	TCGA-77-7141	LUSC	TCGA	RRHELSDIT	DEG_APCC_DBOX_1	736:744	Mutation rewiring degron network	0.2778
p.D734N	DO26450	LUSC	ICGC	RRHELSDIT	DEG_APCC_DBOX_1	736:744	Mutation rewiring degron network	0.2778
p.L561F	TCGA-77-7141	LUSC	TCGA	DSGVGRT	DEG_SCF_TRCP1_1	568:574	Mutation rewiring degron network	0.1389
p.L561F	DO26450	LUSC	ICGC	DSGVGRT	DEG_SCF_TRCP1_1	568:574	Mutation rewiring degron network	0.1389
p.P820R	TCGA-90-7769	LUSC	TCGA	VGTPTYS	DEG_SCF_FBW7_1	817:823	Mutation altering degron motif	0.7512
p.K246N	TCGA-AP-A0LM	UCEC	TCGA	LVLHRD	LIG_APCC_ABBA_1	250:255	Mutation substituting flanking lysine	0.3333
p.K246N	DO43306	UCEC	ICGC	LVLHRD	LIG_APCC_ABBA_1	250:255	Mutation substituting flanking lysine	0.3333
p.I560L	TCGA-B5-A3FA	UCEC	TCGA	DSGVGRT	DEG_SCF_TRCP1_1	568:574	Mutation rewiring degron network	0.1111
p.R736C	TCGA-B5-A3FC	UCEC	TCGA	RRHELSDIT	DEG_APCC_DBOX_1	736:744	Mutation altering degron motif	0.719
p.R736C	DO41871	UCEC	ICGC	RRHELSDIT	DEG_APCC_DBOX_1	736:744	Mutation altering degron motif	0.719
p.D751G	TCGA-BA-4078	HNSC	TCGA	RRHELSDIT	DEG_APCC_DBOX_1	736:744	Mutation rewiring degron network	0.1389
p.R254P	TCGA-BG-A220	UCEC	TCGA	LVLHRD	LIG_APCC_ABBA_1	250:255	Mutation altering degron motif	0.6401
p.R254P	DO41784	UCEC	ICGC	LVLHRD	LIG_APCC_ABBA_1	250:255	Mutation altering degron motif	0.6401
p.V335A	TCGA-BR-7707	STAD	TCGA	MFTPPSE	DEG_SCF_FBW7_2	344:350	Mutation rewiring degron network	0.0833
p.V335A	DO38487	STAD	ICGC	MFTPPSE	DEG_SCF_FBW7_2	344:350	Mutation rewiring degron network	0.0833
p.E243K	TCGA-C5-A8YR	CESC	TCGA	LVLHRD	LIG_APCC_ABBA_1	250:255	Mutation rewiring degron network	0.1389
p.E243K	DO49908	CESC	ICGC	LVLHRD	LIG_APCC_ABBA_1	250:255	Mutation rewiring degron network	0.1389
p.E243K	SIDM00443	B-Cell Non-Hodgkin's Lymphoma	GDSC	LVLHRD	LIG_APCC_ABBA_1	250:255	Mutation rewiring degron network	0.1389
p.P747L	TCGA-CN-4734	HNSC	TCGA	RRHELSDIT	DEG_APCC_DBOX_1	736:744	Mutation rewiring degron network	0.25
p.P747L	DO15446	HNSC	ICGC	RRHELSDIT	DEG_APCC_DBOX_1	736:744	Mutation rewiring degron network	0.25
p.S577R	TCGA-CN-4739	HNSC	TCGA	DSGVGRT	DEG_SCF_TRCP1_1	568:574	Mutation rewiring degron network	0.25
p.E813A	TCGA-CV-5432	HNSC	TCGA	VGTPTYS	DEG_SCF_FBW7_1	817:823	Mutation rewiring degron network	0.2222
p.E813K	TCGA-CV-7568	HNSC	TCGA	VGTPTYS	DEG_SCF_FBW7_1	817:823	Mutation rewiring degron network	0.2222
p.E813K	DO14160	HNSC	ICGC	VGTPTYS	DEG_SCF_FBW7_1	817:823	Mutation rewiring degron network	0.2222
p.T346M	TCGA-D1-A103	UCEC	TCGA	MFTPPSE	DEG_SCF_FBW7_2	344:350	Mutation altering degron motif	0.7423
p.T346M	TCGA-FU-A40J	CESC	TCGA	MFTPPSE	DEG_SCF_FBW7_2	344:350	Mutation altering degron motif	0.7423
p.T346M	DO44314	CESC	ICGC	MFTPPSE	DEG_SCF_FBW7_2	344:350	Mutation altering degron motif	0.7423
p.T346M	DO42312	UCEC	ICGC	MFTPPSE	DEG_SCF_FBW7_2	344:350	Mutation altering degron motif	0.7423
p.P815S	TCGA-D3-A8GI	SKCM	TCGA	VGTPTYS	DEG_SCF_FBW7_1	817:823	Mutation rewiring degron network	0.2778
p.T812M	TCGA-DU-6392	LGG	TCGA	VGTPTYS	DEG_SCF_FBW7_1	817:823	Mutation rewiring degron network	0.1944
p.T812M	DO233797	GACA	ICGC	VGTPTYS	DEG_SCF_FBW7_1	817:823	Mutation rewiring degron network	0.1944
p.T812M	DO22237	LGG	ICGC	VGTPTYS	DEG_SCF_FBW7_1	817:823	Mutation rewiring degron network	0.1944
p.S351F	TCGA-EB-A431	SKCM	TCGA	MFTPPSE	DEG_SCF_FBW7_2	344:350	Mutation rewiring degron network	0.3056
p.S351F	DO37671	SKCM	ICGC	MFTPPSE	DEG_SCF_FBW7_2	344:350	Mutation rewiring degron network	0.3056
p.T744A	TCGA-EC-A24G	UCEC	TCGA	RRHELSDIT	DEG_APCC_DBOX_1	736:744	Mutation altering degron motif	0.6028
p.T744A	DO40996	UCEC	ICGC	RRHELSDIT	DEG_APCC_DBOX_1	736:744	Mutation altering degron motif	0.6028
p.R573Q	TCGA-EJ-7782	PRAD	TCGA	DSGVGRT	DEG_SCF_TRCP1_1	568:574	Mutation altering degron motif	0.6218
p.T821I	TCGA-ER-A194	SKCM	TCGA	VGTPTYS	DEG_SCF_FBW7_1	817:823	Mutation altering degron motif	0.5966
p.G260E	TCGA-EY-A1GI	UCEC	TCGA	LVLHRD	LIG_APCC_ABBA_1	250:255	Mutation rewiring degron network	0.1944
p.G260E	DO41211	UCEC	ICGC	LVLHRD	LIG_APCC_ABBA_1	250:255	Mutation rewiring degron network	0.1944
p.R737I	TCGA-F7-A624	HNSC	TCGA	RRHELSDIT	DEG_APCC_DBOX_1	736:744	Mutation altering degron motif	0.8102
p.R737I	DO44440	HNSC	ICGC	RRHELSDIT	DEG_APCC_DBOX_1	736:744	Mutation altering degron motif	0.8102
p.T812K	TCGA-NJ-A4YQ	LUAD	TCGA	VGTPTYS	DEG_SCF_FBW7_1	817:823	Mutation rewiring degron network	0.1944
p.T812K	DO218944	LUAD	ICGC	VGTPTYS	DEG_SCF_FBW7_1	817:823	Mutation rewiring degron network	0.1944
p.R727C	TCGA-QC-A7B5	SARC	TCGA	RRHELSDIT	DEG_APCC_DBOX_1	736:744	Mutation rewiring degron network	0.0833
p.R727C	DO220239	SARC	ICGC	RRHELSDIT	DEG_APCC_DBOX_1	736:744	Mutation rewiring degron network	0.0833
p.R727C	SIDM02079	Esophageal Carcinoma	GDSC	RRHELSDIT	DEG_APCC_DBOX_1	736:744	Mutation rewiring degron network	0.0833
p.S258F	TCGA-UD-AABZ	MESO	TCGA	LVLHRD	LIG_APCC_ABBA_1	250:255	Mutation rewiring degron network	0.25
p.D751N	TCGA-XF-A9T5	BLCA	TCGA	RRHELSDIT	DEG_APCC_DBOX_1	736:744	Mutation rewiring degron network	0.1389
p.D751N	DO51925	BLCA	ICGC	RRHELSDIT	DEG_APCC_DBOX_1	736:744	Mutation rewiring degron network	0.1389
p.D248N	DO3322	BRCA	ICGC	LVLHRD	LIG_APCC_ABBA_1	250:255	Mutation rewiring degron network	0.2778
p.S583T	DO223000	BTCA	ICGC	DSGVGRT	DEG_SCF_TRCP1_1	568:574	Mutation rewiring degron network	0.0833
p.A250V	DO228070	EOPC	ICGC	LVLHRD	LIG_APCC_ABBA_1	250:255	Mutation altering degron motif	0.6936
p.G354V	DO50407	ESAD	ICGC	MFTPPSE	DEG_SCF_FBW7_2	344:350	Mutation rewiring degron network	0.2222
p.S584P	DO10842	ESAD	ICGC	DSGVGRT	DEG_SCF_TRCP1_1	568:574	Mutation rewiring degron network	0.0556
p.G570S	DO234343	ESAD	ICGC	DSGVGRT	DEG_SCF_TRCP1_1	568:574	Mutation altering degron motif	0.6993
p.D249N	DO233798	GACA	ICGC	LVLHRD	LIG_APCC_ABBA_1	250:255	Mutation blocking phosphorylation signal	0.75
p.D249N	DO36881	READ	ICGC	LVLHRD	LIG_APCC_ABBA_1	250:255	Mutation blocking phosphorylation signal	0.75
p.R338K	DO233817	GACA	ICGC	MFTPPSE	DEG_SCF_FBW7_2	344:350	Mutation rewiring degron network	0.1667
p.T360N	DO229031	LICA	ICGC	MFTPPSE	DEG_SCF_FBW7_2	344:350	Mutation rewiring degron network	0.0556
p.A558D	DO229041	LICA	ICGC	DSGVGRT	DEG_SCF_TRCP1_1	568:574	Mutation rewiring degron network	0.0556
p.Q243K	DO229009	LICA	ICGC	LVLHRD	LIG_APCC_ABBA_1	250:255	Mutation rewiring degron network	0.1389
p.D814Y	DO23164	LINC	ICGC	VGTPTYS	DEG_SCF_FBW7_1	817:823	Mutation rewiring degron network	0.25
p.S562C	DO48759	LIRI	ICGC	DSGVGRT	DEG_SCF_TRCP1_1	568:574	Mutation rewiring degron network	0.1667
p.R583P	DO26052	LUAD	ICGC	DSGVGRT	DEG_SCF_TRCP1_1	568:574	Mutation rewiring degron network	0.0833
p.S337R	DO51193	LUAD	ICGC	MFTPPSE	DEG_SCF_FBW7_2	344:350	Mutation rewiring degron network	0.1389
p.S750F	DO220851	MELA	ICGC	RRHELSDIT	DEG_APCC_DBOX_1	736:744	Mutation blocking phosphorylation signal	0.6111
p.R583C	DO232761	PBCA	ICGC	DSGVGRT	DEG_SCF_TRCP1_1	568:574	Mutation rewiring degron network	0.0833
p.H349R	DO232224	PBCA	ICGC	MFTPPSE	DEG_SCF_FBW7_2	344:350	Mutation altering degron motif	0.8244
p.S253F	DO47272	SKCM	ICGC	LVLHRD	LIG_APCC_ABBA_1	250:255	Mutation altering degron motif	0.7982
p.T570N	DO41871	UCEC	ICGC	DSGVGRT	DEG_SCF_TRCP1_1	568:574	Mutation altering degron motif	0.7055
p.R575C	DO43811	UCEC	ICGC	DSGVGRT	DEG_SCF_TRCP1_1	568:574	Mutation rewiring degron network	0.3056
p.R573W	SIDM02068	Esophageal Carcinoma	GDSC	DSGVGRT	DEG_SCF_TRCP1_1	568:574	Mutation altering degron motif	0.7523
p.E582K	SIDM02021	Esophageal Carcinoma	GDSC	DSGVGRT	DEG_SCF_TRCP1_1	568:574	Mutation rewiring degron network	0.1111
p.D753N	SIDM00789	Colorectal Carcinoma	GDSC	RRHELSDIT	DEG_APCC_DBOX_1	736:744	Mutation rewiring degron network	0.0833
p.D753N	HCT-15	large intestine	COSMIC	RRHELSDIT	DEG_APCC_DBOX_1	736:744	Mutation rewiring degron network	0.0833
p.R254W	SIDM00945	Colorectal Carcinoma	GDSC	LVLHRD	LIG_APCC_ABBA_1	250:255	Mutation altering degron motif	0.7523
p.R254W	CL-34	large intestine	COSMIC	LVLHRD	LIG_APCC_ABBA_1	250:255	Mutation altering degron motif	0.7523
p.L809H	SIDM00447	B-Lymphoblastic Leukemia	GDSC	VGTPTYS	DEG_SCF_FBW7_1	817:823	Mutation rewiring degron network	0.1111
p.L809H	REH	haematopoietic and lymphoid tissue	COSMIC	VGTPTYS	DEG_SCF_FBW7_1	817:823	Mutation rewiring degron network	0.1111
p.L808M	SIDM00660	Colorectal Carcinoma	GDSC	VGTPTYS	DEG_SCF_FBW7_1	817:823	Mutation rewiring degron network	0.0833
p.L808M	LS-411N	large intestine	COSMIC	VGTPTYS	DEG_SCF_FBW7_1	817:823	Mutation rewiring degron network	0.0833
p.G818R	SIDM01695	Acute Myeloid Leukemia	GDSC	VGTPTYS	DEG_SCF_FBW7_1	817:823	Mutation altering degron motif	0.6457
p.R736H	SIDM01574	Plasma Cell Myeloma	GDSC	RRHELSDIT	DEG_APCC_DBOX_1	736:744	Mutation altering degron motif	0.7133
p.R729T	ACH-000022	Pancreatic Cancer	CCLE	RRHELSDIT	DEG_APCC_DBOX_1	736:744	Mutation rewiring degron network	0.1389
p.D814G	ACH-000229	Non-Cancerous	CCLE	VGTPTYS	DEG_SCF_FBW7_1	817:823	Mutation rewiring degron network	0.25
p.P566T	ACH-000389	Brain Cancer	CCLE	DSGVGRT	DEG_SCF_TRCP1_1	568:574	Mutation rewiring degron network	0.2778
p.P566T	H4	central nervous system	COSMIC	DSGVGRT	DEG_SCF_TRCP1_1	568:574	Mutation rewiring degron network	0.2778
p.K748N	ACH-000566	Bladder Cancer	CCLE	RRHELSDIT	DEG_APCC_DBOX_1	736:744	Mutation rewiring degron network	0.2222
p.K748N	SW1710	urinary tract	COSMIC	RRHELSDIT	DEG_APCC_DBOX_1	736:744	Mutation rewiring degron network	0.2222
p.D349H	ACH-000740	Head and Neck Cancer	CCLE	MFTPPSE	DEG_SCF_FBW7_2	344:350	Mutation altering degron motif	0.7688
p.D349H	A253	salivary gland	COSMIC	MFTPPSE	DEG_SCF_FBW7_2	344:350	Mutation altering degron motif	0.7688
p.T567M	ACH-000807	Brain Cancer	CCLE	DSGVGRT	DEG_SCF_TRCP1_1	568:574	Mutation rewiring degron network	0.3056
p.L335M	ACH-000813	Lung Cancer	CCLE	MFTPPSE	DEG_SCF_FBW7_2	344:350	Mutation rewiring degron network	0.0833
p.F342L	ACH-000820	Colon/Colorectal Cancer	CCLE	MFTPPSE	DEG_SCF_FBW7_2	344:350	Mutation rewiring degron network	0.2778
p.F342L	SW403	large intestine	COSMIC	MFTPPSE	DEG_SCF_FBW7_2	344:350	Mutation rewiring degron network	0.2778
p.D334E	ACH-000875	Lung Cancer	CCLE	MFTPPSE	DEG_SCF_FBW7_2	344:350	Mutation rewiring degron network	0.0556
p.D334E	NCI-H2347	lung	COSMIC	MFTPPSE	DEG_SCF_FBW7_2	344:350	Mutation rewiring degron network	0.0556
p.V259M	ACH-000936	Ovarian Cancer	CCLE	LVLHRD	LIG_APCC_ABBA_1	250:255	Mutation rewiring degron network	0.2222
p.V259M	EFO-27	ovary	COSMIC	LVLHRD	LIG_APCC_ABBA_1	250:255	Mutation rewiring degron network	0.2222
p.D351N	ACH-000972	Endometrial/Uterine Cancer	CCLE	MFTPPSE	DEG_SCF_FBW7_2	344:350	Mutation rewiring degron network	0.3056
p.N747D	ACH-000982	Colon/Colorectal Cancer	CCLE	RRHELSDIT	DEG_APCC_DBOX_1	736:744	Mutation rewiring degron network	0.25
p.N747D	ACH-001345	Colon/Colorectal Cancer	CCLE	RRHELSDIT	DEG_APCC_DBOX_1	736:744	Mutation rewiring degron network	0.25
p.N747D	GP5d	large intestine	COSMIC	RRHELSDIT	DEG_APCC_DBOX_1	736:744	Mutation rewiring degron network	0.25
p.D334N	ACH-000987	Skin Cancer	CCLE	MFTPPSE	DEG_SCF_FBW7_2	344:350	Mutation rewiring degron network	0.0556
p.D334N	Mewo	skin	COSMIC	MFTPPSE	DEG_SCF_FBW7_2	344:350	Mutation rewiring degron network	0.0556
p.K741N	ACH-001358	Breast Cancer	CCLE	RRHELSDIT	DEG_APCC_DBOX_1	736:744	Mutation altering degron motif	0.6918
p.K741N	MDA-MB-330	breast	COSMIC	RRHELSDIT	DEG_APCC_DBOX_1	736:744	Mutation altering degron motif	0.6918
p.P566S	ACH-001664	Gastric Cancer	CCLE	DSGVGRT	DEG_SCF_TRCP1_1	568:574	Mutation rewiring degron network	0.2778
p.P356S	ACH-001853	Bile Duct Cancer	CCLE	MFTPPSE	DEG_SCF_FBW7_2	344:350	Mutation rewiring degron network	0.1667
p.P335S	COLO-792	skin	COSMIC	MFTPPSE	DEG_SCF_FBW7_2	344:350	Mutation rewiring degron network	0.0833
p.E347G	GP5d	large intestine	COSMIC	MFTPPSE	DEG_SCF_FBW7_2	344:350	Mutation altering degron motif	0.7199
p.L354M	NCI-H2110	lung	COSMIC	MFTPPSE	DEG_SCF_FBW7_2	344:350	Mutation rewiring degron network	0.2222
p.V338M	U251	central nervous system	COSMIC	MFTPPSE	DEG_SCF_FBW7_2	344:350	Mutation rewiring degron network	0.1667
p.K340E	MC-1010	haematopoietic and lymphoid tissue	COSMIC	MFTPPSE	DEG_SCF_FBW7_2	344:350	Mutation rewiring degron network	0.2222
p.G346A	BICR78	upper aerodigestive tract	COSMIC	MFTPPSE	DEG_SCF_FBW7_2	344:350	Mutation altering degron motif	0.754
p.K345R	NCI-H250	lung	COSMIC	MFTPPSE	DEG_SCF_FBW7_2	344:350	Mutation altering degron motif	0.7237
p.L559P	MHH-PREB-1	haematopoietic and lymphoid tissue	COSMIC	DSGVGRT	DEG_SCF_TRCP1_1	568:574	Mutation rewiring degron network	0.0833
p.R350H	EFO-27	ovary	COSMIC	MFTPPSE	DEG_SCF_FBW7_2	344:350	Mutation altering degron motif	0.8244

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PDZRN3

UniProt ID: Q9UPQ7

Entrez ID: 23024

Protein name: E3 ubiquitin-protein ligase PDZRN3 (EC 2.3.2.27) (Ligand of Numb protein X 3) (PDZ domain-containing RING finger protein 3) (RING-type E3 ubiquitin transferase PDZRN3) (Semaphorin cytoplasmic domain-associated protein 3) (Protein SEMACAP3)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PDZRN3 in