DegronMD

Uniprot ID: Q9UPQ7

Source protein: E3 ubiquitin-protein ligase PDZRN3

Source gene: PDZRN3

Class: DEG_APCC_DBOX_1

Location: 736:744

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9654

ASA_SCORE: 94.2889

COIL: 0.6233

CONS_SCORE: 0.5693

DSS_SCORE: 0.4506

HELIX: 0.2726

FCONS_SCORE: 1.0413

RIG_SCORE: 0.7663

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.N730S	TCGA-17-Z049	LUAD	TCGA	RRHELSDIT	DEG_APCC_DBOX_1	0.1667
p.D734N	TCGA-77-7141	LUSC	TCGA	RRHELSDIT	DEG_APCC_DBOX_1	0.2778
p.D734N	DO26450	LUSC	ICGC	RRHELSDIT	DEG_APCC_DBOX_1	0.2778
p.R736C	TCGA-B5-A3FC	UCEC	TCGA	RRHELSDIT	DEG_APCC_DBOX_1	0.719
p.R736C	DO41871	UCEC	ICGC	RRHELSDIT	DEG_APCC_DBOX_1	0.719
p.D751G	TCGA-BA-4078	HNSC	TCGA	RRHELSDIT	DEG_APCC_DBOX_1	0.1389
p.P747L	TCGA-CN-4734	HNSC	TCGA	RRHELSDIT	DEG_APCC_DBOX_1	0.25
p.P747L	DO15446	HNSC	ICGC	RRHELSDIT	DEG_APCC_DBOX_1	0.25
p.T744A	TCGA-EC-A24G	UCEC	TCGA	RRHELSDIT	DEG_APCC_DBOX_1	0.6028
p.T744A	DO40996	UCEC	ICGC	RRHELSDIT	DEG_APCC_DBOX_1	0.6028
p.R737I	TCGA-F7-A624	HNSC	TCGA	RRHELSDIT	DEG_APCC_DBOX_1	0.8102
p.R737I	DO44440	HNSC	ICGC	RRHELSDIT	DEG_APCC_DBOX_1	0.8102
p.R727C	TCGA-QC-A7B5	SARC	TCGA	RRHELSDIT	DEG_APCC_DBOX_1	0.0833
p.R727C	DO220239	SARC	ICGC	RRHELSDIT	DEG_APCC_DBOX_1	0.0833
p.R727C	SIDM02079	Esophageal Carcinoma	GDSC	RRHELSDIT	DEG_APCC_DBOX_1	0.0833
p.D751N	TCGA-XF-A9T5	BLCA	TCGA	RRHELSDIT	DEG_APCC_DBOX_1	0.1389
p.D751N	DO51925	BLCA	ICGC	RRHELSDIT	DEG_APCC_DBOX_1	0.1389
p.S750F	DO220851	MELA	ICGC	RRHELSDIT	DEG_APCC_DBOX_1	0.6111
p.D753N	SIDM00789	Colorectal Carcinoma	GDSC	RRHELSDIT	DEG_APCC_DBOX_1	0.0833
p.D753N	HCT-15	large_intestine	COSMIC	RRHELSDIT	DEG_APCC_DBOX_1	0.0833
p.R736H	SIDM01574	Plasma Cell Myeloma	GDSC	RRHELSDIT	DEG_APCC_DBOX_1	0.7133
p.R729T	ACH-000022	Pancreatic Cancer	CCLE	RRHELSDIT	DEG_APCC_DBOX_1	0.1389
p.K748N	ACH-000566	Bladder Cancer	CCLE	RRHELSDIT	DEG_APCC_DBOX_1	0.2222
p.K748N	SW1710	urinary_tract	COSMIC	RRHELSDIT	DEG_APCC_DBOX_1	0.2222
p.N747D	ACH-000982	Colon/Colorectal Cancer	CCLE	RRHELSDIT	DEG_APCC_DBOX_1	0.25
p.N747D	ACH-001345	Colon/Colorectal Cancer	CCLE	RRHELSDIT	DEG_APCC_DBOX_1	0.25
p.N747D	GP5d	large_intestine	COSMIC	RRHELSDIT	DEG_APCC_DBOX_1	0.25
p.K741N	ACH-001358	Breast Cancer	CCLE	RRHELSDIT	DEG_APCC_DBOX_1	0.6918
p.K741N	MDA-MB-330	breast	COSMIC	RRHELSDIT	DEG_APCC_DBOX_1	0.6918

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: RRHELSDIT

Degron related mutations and impact score

Drug responses associated with PDZRN3 mutations

All proteins holding degron of RRHELSDIT

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UPQ7	E3 ubiquitin-protein ligase PDZRN3	DEG_APCC_DBOX_1	736:744	RRHELSDIT	APC,CDC20,FZR1	0.9654	More...