DegronMD

Uniprot ID: Q9UPQ7

Source protein: E3 ubiquitin-protein ligase PDZRN3

Source gene: PDZRN3

Class: DEG_SCF_FBW7_1

Location: 817:823

E3 ligase: FBXW7

DEGRON score: 0.9828

ASA_SCORE: 86.4714

COIL: 0.9426

CONS_SCORE: 0.3439

DSS_SCORE: 0.6684

HELIX: 0.0163

FCONS_SCORE: 0.8706

RIG_SCORE: 0.6594

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T812A	TCGA-06-5416	GBM	TCGA	VGTPTYS	DEG_SCF_FBW7_1	0.1944
p.T812A	DO10880	GBM	ICGC	VGTPTYS	DEG_SCF_FBW7_1	0.1944
p.D830G	TCGA-17-Z047	LUAD	TCGA	VGTPTYS	DEG_SCF_FBW7_1	0.1389
p.T821N	TCGA-18-4721	LUSC	TCGA	VGTPTYS	DEG_SCF_FBW7_1	0.5944
p.K827N	TCGA-21-1079	LUSC	TCGA	VGTPTYS	DEG_SCF_FBW7_1	0.3333
p.T819S	TCGA-24-0982	OV	TCGA	VGTPTYS	DEG_SCF_FBW7_1	0.8227
p.L829M	TCGA-44-7661	LUAD	TCGA	VGTPTYS	DEG_SCF_FBW7_1	0.1667
p.L829M	DO23602	LUAD	ICGC	VGTPTYS	DEG_SCF_FBW7_1	0.1667
p.P820R	TCGA-90-7769	LUSC	TCGA	VGTPTYS	DEG_SCF_FBW7_1	0.7512
p.E813A	TCGA-CV-5432	HNSC	TCGA	VGTPTYS	DEG_SCF_FBW7_1	0.2222
p.E813K	TCGA-CV-7568	HNSC	TCGA	VGTPTYS	DEG_SCF_FBW7_1	0.2222
p.E813K	DO14160	HNSC	ICGC	VGTPTYS	DEG_SCF_FBW7_1	0.2222
p.P815S	TCGA-D3-A8GI	SKCM	TCGA	VGTPTYS	DEG_SCF_FBW7_1	0.2778
p.T812M	TCGA-DU-6392	LGG	TCGA	VGTPTYS	DEG_SCF_FBW7_1	0.1944
p.T812M	DO233797	GACA	ICGC	VGTPTYS	DEG_SCF_FBW7_1	0.1944
p.T812M	DO22237	LGG	ICGC	VGTPTYS	DEG_SCF_FBW7_1	0.1944
p.T821I	TCGA-ER-A194	SKCM	TCGA	VGTPTYS	DEG_SCF_FBW7_1	0.5966
p.T812K	TCGA-NJ-A4YQ	LUAD	TCGA	VGTPTYS	DEG_SCF_FBW7_1	0.1944
p.T812K	DO218944	LUAD	ICGC	VGTPTYS	DEG_SCF_FBW7_1	0.1944
p.D814Y	DO23164	LINC	ICGC	VGTPTYS	DEG_SCF_FBW7_1	0.25
p.L809H	SIDM00447	B-Lymphoblastic Leukemia	GDSC	VGTPTYS	DEG_SCF_FBW7_1	0.1111
p.L809H	REH	haematopoietic_and_lymphoid_tissue	COSMIC	VGTPTYS	DEG_SCF_FBW7_1	0.1111
p.L808M	SIDM00660	Colorectal Carcinoma	GDSC	VGTPTYS	DEG_SCF_FBW7_1	0.0833
p.L808M	LS-411N	large_intestine	COSMIC	VGTPTYS	DEG_SCF_FBW7_1	0.0833
p.G818R	SIDM01695	Acute Myeloid Leukemia	GDSC	VGTPTYS	DEG_SCF_FBW7_1	0.6457
p.D814G	ACH-000229	Non-Cancerous	CCLE	VGTPTYS	DEG_SCF_FBW7_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UPQ7	E3 ubiquitin-protein ligase PDZRN3	DEG_SCF_FBW7_1	817:823	VGTPTYS	FBXW7	0.9828	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VGTPTYS

Degron related mutations and impact score

Drug responses associated with PDZRN3 mutations

All proteins holding degron of VGTPTYS