DegronMD

Uniprot ID: Q9UPQ7

Source protein: E3 ubiquitin-protein ligase PDZRN3

Source gene: PDZRN3

Class: DEG_SCF_FBW7_2

Location: 344:350

E3 ligase: FBXW7

DEGRON score: 0.8093

ASA_SCORE: 92.9143

COIL: 0.898

CONS_SCORE: 0.4212

DSS_SCORE: 0.5981

HELIX: 0.0517

FCONS_SCORE: 0.7383

RIG_SCORE: 0.7118

Degron related mutations and impact score

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.H349R	DO232224	PBCA	ICGC	MFTPPSE	DEG_SCF_FBW7_2	0.8244
p.R350H	EFO-27	ovary	COSMIC	MFTPPSE	DEG_SCF_FBW7_2	0.8244
p.D349H	ACH-000740	Head and Neck Cancer	CCLE	MFTPPSE	DEG_SCF_FBW7_2	0.7688
p.D349H	A253	salivary_gland	COSMIC	MFTPPSE	DEG_SCF_FBW7_2	0.7688
p.G346A	BICR78	upper_aerodigestive_tract	COSMIC	MFTPPSE	DEG_SCF_FBW7_2	0.754
p.T346M	TCGA-D1-A103	UCEC	TCGA	MFTPPSE	DEG_SCF_FBW7_2	0.7423
p.T346M	TCGA-FU-A40J	CESC	TCGA	MFTPPSE	DEG_SCF_FBW7_2	0.7423
p.T346M	DO44314	CESC	ICGC	MFTPPSE	DEG_SCF_FBW7_2	0.7423
p.T346M	DO42312	UCEC	ICGC	MFTPPSE	DEG_SCF_FBW7_2	0.7423
p.K345R	NCI-H250	lung	COSMIC	MFTPPSE	DEG_SCF_FBW7_2	0.7237
p.E347G	GP5d	large_intestine	COSMIC	MFTPPSE	DEG_SCF_FBW7_2	0.7199
p.S351F	TCGA-EB-A431	SKCM	TCGA	MFTPPSE	DEG_SCF_FBW7_2	0.3056
p.S351F	DO37671	SKCM	ICGC	MFTPPSE	DEG_SCF_FBW7_2	0.3056
p.D351N	ACH-000972	Endometrial/Uterine Cancer	CCLE	MFTPPSE	DEG_SCF_FBW7_2	0.3056
p.F342L	ACH-000820	Colon/Colorectal Cancer	CCLE	MFTPPSE	DEG_SCF_FBW7_2	0.2778
p.F342L	SW403	large_intestine	COSMIC	MFTPPSE	DEG_SCF_FBW7_2	0.2778
p.G354V	DO50407	ESAD	ICGC	MFTPPSE	DEG_SCF_FBW7_2	0.2222
p.L354M	NCI-H2110	lung	COSMIC	MFTPPSE	DEG_SCF_FBW7_2	0.2222
p.K340E	MC-1010	haematopoietic_and_lymphoid_tissue	COSMIC	MFTPPSE	DEG_SCF_FBW7_2	0.2222
p.R338K	DO233817	GACA	ICGC	MFTPPSE	DEG_SCF_FBW7_2	0.1667
p.P356S	ACH-001853	Bile Duct Cancer	CCLE	MFTPPSE	DEG_SCF_FBW7_2	0.1667
p.V338M	U251	central_nervous_system	COSMIC	MFTPPSE	DEG_SCF_FBW7_2	0.1667
p.S337R	DO51193	LUAD	ICGC	MFTPPSE	DEG_SCF_FBW7_2	0.1389
p.L336F	TCGA-22-5473	LUSC	TCGA	MFTPPSE	DEG_SCF_FBW7_2	0.1111
p.L336F	DO26467	LUSC	ICGC	MFTPPSE	DEG_SCF_FBW7_2	0.1111

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Drug responses associated with PDZRN3 mutations

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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All proteins holding degron of MFTPPSE

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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UPQ7	E3 ubiquitin-protein ligase PDZRN3	DEG_SCF_FBW7_2	344:350	MFTPPSE	FBXW7	0.8093	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: MFTPPSE

Degron related mutations and impact score

Drug responses associated with PDZRN3 mutations

All proteins holding degron of MFTPPSE