DegronMD

Uniprot ID: Q9UPQ7

Source protein: E3 ubiquitin-protein ligase PDZRN3

Source gene: PDZRN3

Class: DEG_SCF_FBW7_2

Location: 344:350

E3 ligase: FBXW7

DEGRON score: 0.8093

ASA_SCORE: 92.9143

COIL: 0.898

CONS_SCORE: 0.4212

DSS_SCORE: 0.5981

HELIX: 0.0517

FCONS_SCORE: 0.7383

RIG_SCORE: 0.7118

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L336F	TCGA-22-5473	LUSC	TCGA	MFTPPSE	DEG_SCF_FBW7_2	0.1111
p.L336F	DO26467	LUSC	ICGC	MFTPPSE	DEG_SCF_FBW7_2	0.1111
p.V335A	TCGA-BR-7707	STAD	TCGA	MFTPPSE	DEG_SCF_FBW7_2	0.0833
p.V335A	DO38487	STAD	ICGC	MFTPPSE	DEG_SCF_FBW7_2	0.0833
p.T346M	TCGA-D1-A103	UCEC	TCGA	MFTPPSE	DEG_SCF_FBW7_2	0.7423
p.T346M	TCGA-FU-A40J	CESC	TCGA	MFTPPSE	DEG_SCF_FBW7_2	0.7423
p.T346M	DO44314	CESC	ICGC	MFTPPSE	DEG_SCF_FBW7_2	0.7423
p.T346M	DO42312	UCEC	ICGC	MFTPPSE	DEG_SCF_FBW7_2	0.7423
p.S351F	TCGA-EB-A431	SKCM	TCGA	MFTPPSE	DEG_SCF_FBW7_2	0.3056
p.S351F	DO37671	SKCM	ICGC	MFTPPSE	DEG_SCF_FBW7_2	0.3056
p.G354V	DO50407	ESAD	ICGC	MFTPPSE	DEG_SCF_FBW7_2	0.2222
p.R338K	DO233817	GACA	ICGC	MFTPPSE	DEG_SCF_FBW7_2	0.1667
p.T360N	DO229031	LICA	ICGC	MFTPPSE	DEG_SCF_FBW7_2	0.0556
p.S337R	DO51193	LUAD	ICGC	MFTPPSE	DEG_SCF_FBW7_2	0.1389
p.H349R	DO232224	PBCA	ICGC	MFTPPSE	DEG_SCF_FBW7_2	0.8244
p.D349H	ACH-000740	Head and Neck Cancer	CCLE	MFTPPSE	DEG_SCF_FBW7_2	0.7688
p.D349H	A253	salivary_gland	COSMIC	MFTPPSE	DEG_SCF_FBW7_2	0.7688
p.L335M	ACH-000813	Lung Cancer	CCLE	MFTPPSE	DEG_SCF_FBW7_2	0.0833
p.F342L	ACH-000820	Colon/Colorectal Cancer	CCLE	MFTPPSE	DEG_SCF_FBW7_2	0.2778
p.F342L	SW403	large_intestine	COSMIC	MFTPPSE	DEG_SCF_FBW7_2	0.2778
p.D334E	ACH-000875	Lung Cancer	CCLE	MFTPPSE	DEG_SCF_FBW7_2	0.0556
p.D334E	NCI-H2347	lung	COSMIC	MFTPPSE	DEG_SCF_FBW7_2	0.0556
p.D351N	ACH-000972	Endometrial/Uterine Cancer	CCLE	MFTPPSE	DEG_SCF_FBW7_2	0.3056
p.D334N	ACH-000987	Skin Cancer	CCLE	MFTPPSE	DEG_SCF_FBW7_2	0.0556
p.D334N	Mewo	skin	COSMIC	MFTPPSE	DEG_SCF_FBW7_2	0.0556
p.P356S	ACH-001853	Bile Duct Cancer	CCLE	MFTPPSE	DEG_SCF_FBW7_2	0.1667
p.P335S	COLO-792	skin	COSMIC	MFTPPSE	DEG_SCF_FBW7_2	0.0833
p.E347G	GP5d	large_intestine	COSMIC	MFTPPSE	DEG_SCF_FBW7_2	0.7199
p.L354M	NCI-H2110	lung	COSMIC	MFTPPSE	DEG_SCF_FBW7_2	0.2222
p.V338M	U251	central_nervous_system	COSMIC	MFTPPSE	DEG_SCF_FBW7_2	0.1667
p.K340E	MC-1010	haematopoietic_and_lymphoid_tissue	COSMIC	MFTPPSE	DEG_SCF_FBW7_2	0.2222
p.G346A	BICR78	upper_aerodigestive_tract	COSMIC	MFTPPSE	DEG_SCF_FBW7_2	0.754
p.K345R	NCI-H250	lung	COSMIC	MFTPPSE	DEG_SCF_FBW7_2	0.7237
p.R350H	EFO-27	ovary	COSMIC	MFTPPSE	DEG_SCF_FBW7_2	0.8244

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: MFTPPSE

Degron related mutations and impact score

Drug responses associated with PDZRN3 mutations

All proteins holding degron of MFTPPSE

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UPQ7	E3 ubiquitin-protein ligase PDZRN3	DEG_SCF_FBW7_2	344:350	MFTPPSE	FBXW7	0.8093	More...