DegronMD

Uniprot ID: Q9UPQ7

Source protein: E3 ubiquitin-protein ligase PDZRN3

Source gene: PDZRN3

Class: LIG_APCC_ABBA_1

Location: 250:255

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6997

ASA_SCORE: 51.1

COIL: 0.3397

CONS_SCORE: 0.3084

DSS_SCORE: 0.3465

HELIX: 0.0247

FCONS_SCORE: 0.9977

RIG_SCORE: 0.819

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G242V	TCGA-44-7667	LUAD	TCGA	LVLHRD	LIG_APCC_ABBA_1	0.1111
p.G242V	DO23830	LUAD	ICGC	LVLHRD	LIG_APCC_ABBA_1	0.1111
p.K246N	TCGA-AP-A0LM	UCEC	TCGA	LVLHRD	LIG_APCC_ABBA_1	0.3333
p.K246N	DO43306	UCEC	ICGC	LVLHRD	LIG_APCC_ABBA_1	0.3333
p.R254P	TCGA-BG-A220	UCEC	TCGA	LVLHRD	LIG_APCC_ABBA_1	0.6401
p.R254P	DO41784	UCEC	ICGC	LVLHRD	LIG_APCC_ABBA_1	0.6401
p.E243K	TCGA-C5-A8YR	CESC	TCGA	LVLHRD	LIG_APCC_ABBA_1	0.1389
p.E243K	DO49908	CESC	ICGC	LVLHRD	LIG_APCC_ABBA_1	0.1389
p.E243K	SIDM00443	B-Cell Non-Hodgkin's Lymphoma	GDSC	LVLHRD	LIG_APCC_ABBA_1	0.1389
p.G260E	TCGA-EY-A1GI	UCEC	TCGA	LVLHRD	LIG_APCC_ABBA_1	0.1944
p.G260E	DO41211	UCEC	ICGC	LVLHRD	LIG_APCC_ABBA_1	0.1944
p.S258F	TCGA-UD-AABZ	MESO	TCGA	LVLHRD	LIG_APCC_ABBA_1	0.25
p.D248N	DO3322	BRCA	ICGC	LVLHRD	LIG_APCC_ABBA_1	0.2778
p.A250V	DO228070	EOPC	ICGC	LVLHRD	LIG_APCC_ABBA_1	0.6936
p.D249N	DO233798	GACA	ICGC	LVLHRD	LIG_APCC_ABBA_1	0.75
p.D249N	DO36881	READ	ICGC	LVLHRD	LIG_APCC_ABBA_1	0.75
p.Q243K	DO229009	LICA	ICGC	LVLHRD	LIG_APCC_ABBA_1	0.1389
p.S253F	DO47272	SKCM	ICGC	LVLHRD	LIG_APCC_ABBA_1	0.7982
p.R254W	SIDM00945	Colorectal Carcinoma	GDSC	LVLHRD	LIG_APCC_ABBA_1	0.7523
p.R254W	CL-34	large_intestine	COSMIC	LVLHRD	LIG_APCC_ABBA_1	0.7523
p.V259M	ACH-000936	Ovarian Cancer	CCLE	LVLHRD	LIG_APCC_ABBA_1	0.2222
p.V259M	EFO-27	ovary	COSMIC	LVLHRD	LIG_APCC_ABBA_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UPQ7	E3 ubiquitin-protein ligase PDZRN3	LIG_APCC_ABBA_1	250:255	LVLHRD	APC,CDC20,FZR1	0.6997	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons