DegronMD

Uniprot ID: Q76G19

Source protein: PDZ domain-containing protein 4

Source gene: PDZD4

Class: DEG_SCF_TRCP1_1

Location: 69:74

E3 ligase: BTRC

DEGRON score: 0.9904

ASA_SCORE: 84.5833

COIL: 0.9147

CONS_SCORE: 0.4837

DSS_SCORE: 0.3675

HELIX: 0.046

FCONS_SCORE: 1.5404

RIG_SCORE: 0.7085

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.I76T	TCGA-AP-A1DK	UCEC	TCGA	DSGTQT	DEG_SCF_TRCP1_1	0.2778
p.I76T	DO42033	UCEC	ICGC	DSGTQT	DEG_SCF_TRCP1_1	0.2778
p.D75N	TCGA-AP-A1E0	UCEC	TCGA	DSGTQT	DEG_SCF_TRCP1_1	0.3056
p.D75N	DO43154	UCEC	ICGC	DSGTQT	DEG_SCF_TRCP1_1	0.3056
p.D75N	SIDM00118	Colorectal Carcinoma	GDSC	DSGTQT	DEG_SCF_TRCP1_1	0.3056
p.D75N	ACH-001081	Colon/Colorectal Cancer	CCLE	DSGTQT	DEG_SCF_TRCP1_1	0.3056
p.D75N	HCC2998	large_intestine	COSMIC	DSGTQT	DEG_SCF_TRCP1_1	0.3056
p.A83V	TCGA-BH-A18G	BRCA	TCGA	DSGTQT	DEG_SCF_TRCP1_1	0.0833
p.A83V	DO3686	BRCA	ICGC	DSGTQT	DEG_SCF_TRCP1_1	0.0833
p.A83V	DO228435	MALY	ICGC	DSGTQT	DEG_SCF_TRCP1_1	0.0833
p.D59E	TCGA-BH-A201	BRCA	TCGA	DSGTQT	DEG_SCF_TRCP1_1	0.0556
p.D59E	DO2192	BRCA	ICGC	DSGTQT	DEG_SCF_TRCP1_1	0.0556
p.E79K	TCGA-EB-A430	SKCM	TCGA	DSGTQT	DEG_SCF_TRCP1_1	0.1944
p.E79K	DO37906	SKCM	ICGC	DSGTQT	DEG_SCF_TRCP1_1	0.1944
p.Q73E	DO228471	BRCA	ICGC	DSGTQT	DEG_SCF_TRCP1_1	0.5633
p.D69G	SIDM01588	Endometrial Carcinoma	GDSC	DSGTQT	DEG_SCF_TRCP1_1	0.7198
p.D69G	ACH-000993	Endometrial/Uterine Cancer	CCLE	DSGTQT	DEG_SCF_TRCP1_1	0.7198
p.A60T	NUGC-3	stomach	COSMIC	DSGTQT	DEG_SCF_TRCP1_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q76G19	PDZ domain-containing protein 4	DEG_SCF_TRCP1_1	69:74	DSGTQT	BTRC	0.9904	More...
Q8N1W2	Zinc finger protein 710	DEG_SCF_TRCP1_1	6:11	DSGTQT	BTRC	0.9124	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons