DegronMD

Uniprot ID: Q8N1W2

Source protein: Zinc finger protein 710

Source gene: ZNF710

Class: DEG_SCF_TRCP1_1

Location: 6:11

E3 ligase: BTRC

DEGRON score: 0.9124

ASA_SCORE: 74.4

COIL: 0.777

CONS_SCORE: 0.6595

DSS_SCORE: 0.3032

HELIX: 0.0547

FCONS_SCORE: 1.0107

RIG_SCORE: 0.7439

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V14A	TCGA-AA-A010	COAD	TCGA	DSGTQT	DEG_SCF_TRCP1_1	0.25
p.S18F	TCGA-CD-8534	STAD	TCGA	DSGTQT	DEG_SCF_TRCP1_1	0.1389
p.S18F	DO47809	STAD	ICGC	DSGTQT	DEG_SCF_TRCP1_1	0.1389
p.A20S	TCGA-DX-A6YT	SARC	TCGA	DSGTQT	DEG_SCF_TRCP1_1	0.0833
p.A20S	DO220007	SARC	ICGC	DSGTQT	DEG_SCF_TRCP1_1	0.0833
p.E2G	TCGA-EP-A2KB	LIHC	TCGA	DSGTQT	DEG_SCF_TRCP1_1	0.2222
p.E2G	DO22932	LIHC	ICGC	DSGTQT	DEG_SCF_TRCP1_1	0.2222
p.V14M	DO50727	ORCA	ICGC	DSGTQT	DEG_SCF_TRCP1_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q76G19	PDZ domain-containing protein 4	DEG_SCF_TRCP1_1	69:74	DSGTQT	BTRC	0.9904	More...
Q8N1W2	Zinc finger protein 710	DEG_SCF_TRCP1_1	6:11	DSGTQT	BTRC	0.9124	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons