DegronMD

Uniprot ID: Q76G19

Source protein: PDZ domain-containing protein 4

Source gene: PDZD4

Class: DEG_SPOP_SBC_1

Location: 302:306

E3 ligase: SPOP

DEGRON score: 0.8947

ASA_SCORE: 83.96

COIL: 0.918

CONS_SCORE: 0.2657

DSS_SCORE: 0.7469

HELIX: 0.0548

FCONS_SCORE: 0.6427

RIG_SCORE: 0.5496

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P303Q	TCGA-85-6561	LUSC	TCGA	PPSST	DEG_SPOP_SBC_1	0.5924
p.P303Q	DO26518	LUSC	ICGC	PPSST	DEG_SPOP_SBC_1	0.5924
p.R313C	TCGA-BK-A6W3	UCEC	TCGA	PPSST	DEG_SPOP_SBC_1	0.1389
p.R313C	DO50076	UCEC	ICGC	PPSST	DEG_SPOP_SBC_1	0.1389
p.G299V	TCGA-BQ-7049	KIRP	TCGA	PPSST	DEG_SPOP_SBC_1	0.25
p.G299V	DO20853	KIRP	ICGC	PPSST	DEG_SPOP_SBC_1	0.25
p.S311R	TCGA-DX-A6YS	SARC	TCGA	PPSST	DEG_SPOP_SBC_1	0.1944
p.S311R	DO229045	LICA	ICGC	PPSST	DEG_SPOP_SBC_1	0.1944
p.S311R	DO220005	SARC	ICGC	PPSST	DEG_SPOP_SBC_1	0.1944
p.E301K	TCGA-EE-A2MF	SKCM	TCGA	PPSST	DEG_SPOP_SBC_1	0.3056
p.E301K	DO222491	MELA	ICGC	PPSST	DEG_SPOP_SBC_1	0.3056
p.E301K	DO51249	SKCM	ICGC	PPSST	DEG_SPOP_SBC_1	0.3056
p.S292R	DO228952	LICA	ICGC	PPSST	DEG_SPOP_SBC_1	0.0556
p.S304R	DO228976	LICA	ICGC	PPSST	DEG_SPOP_SBC_1	0.7427
p.G299E	DO42673	UCEC	ICGC	PPSST	DEG_SPOP_SBC_1	0.25
p.R309W	SNG-M	endometrium	COSMIC	PPSST	DEG_SPOP_SBC_1	0.25
p.E296K	451Lu	skin	COSMIC	PPSST	DEG_SPOP_SBC_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14686	Histone-lysine N-methyltransferase 2D	DEG_SPOP_SBC_1	2967:2971	PPSST	SPOP	0.9664	More...
O60343	TBC1 domain family member 4	DEG_SPOP_SBC_1	646:650	PPSST	SPOP	0.9933	More...
P15529	Membrane cofactor protein	DEG_SPOP_SBC_1	288:292	PPSST	SPOP	0.9554	More...
P15941	Mucin-1	DEG_SPOP_SBC_1	1220:1224	PPSST	SPOP	0.727	More...
P32243	Homeobox protein OTX2	DEG_SPOP_SBC_1	133:137	PPSST	SPOP	0.9927	More...
P42694	Probable helicase with zinc finger domain	DEG_SPOP_SBC_1	1621:1625	PPSST	SPOP	0.9359	More...
P98160	Basement membrane-specific heparan sulfate proteoglycan core protein	DEG_SPOP_SBC_1	3028:3032	PPSST	SPOP	0.7211	More...
Q02641	Voltage-dependent L-type calcium channel subunit beta-1	DEG_SPOP_SBC_1	414:418	PPSST	SPOP	0.8892	More...
Q13796	Protein Shroom2	DEG_SPOP_SBC_1	735:739	PPSST	SPOP	0.8425	More...
Q2M1Z3	Rho GTPase-activating protein 31	DEG_SPOP_SBC_1	1361:1365	PPSST	SPOP	0.9538	More...
Q6P0Q8	Microtubule-associated serine/threonine-protein kinase 2	DEG_SPOP_SBC_1	1645:1649	PPSST	SPOP	0.9971	More...
Q76L83	Putative Polycomb group protein ASXL2	DEG_SPOP_SBC_1	915:919	PPSST	SPOP	0.9866	More...
Q7Z3B3	KAT8 regulatory NSL complex subunit 1	DEG_SPOP_SBC_1	24:28	PPSST	SPOP	0.9977	More...
Q7Z5J4	Retinoic acid-induced protein 1	DEG_SPOP_SBC_1	500:504	PPSST	SPOP	0.7702	More...
Q86SQ0	Pleckstrin homology-like domain family B member 2	DEG_SPOP_SBC_1	553:557	PPSST	SPOP	0.7645	More...
Q86WP2	Vasculin	DEG_SPOP_SBC_1	16:20	PPSST	SPOP	0.9896	More...
Q8IUC6	TIR domain-containing adapter molecule 1	DEG_SPOP_SBC_1	366:370	PPSST	SPOP	0.9854	More...
Q8IWI9	MAX gene-associated protein	DEG_SPOP_SBC_1	1852:1856	PPSST	SPOP	0.9444	More...
Q8N8W4	Omega-hydroxyceramide transacylase	DEG_SPOP_SBC_1	380:384	PPSST	SPOP	0.9792	More...
Q92793	CREB-binding protein	DEG_SPOP_SBC_1	582:586	PPSST	SPOP	0.9689	More...
Q9C0D6	FH2 domain-containing protein 1	DEG_SPOP_SBC_1	931:935	PPSST	SPOP	0.8254	More...
Q9H0X9	Oxysterol-binding protein-related protein 5	DEG_SPOP_SBC_1	15:19	PPSST	SPOP	0.9979	More...
Q9NZM4	BRD4-interacting chromatin-remodeling complex-associated protein	DEG_SPOP_SBC_1	880:884	PPSST	SPOP	0.9899	More...
Q9NZP6	Nuclear pore-associated protein 1	DEG_SPOP_SBC_1	500:504	PPSST	SPOP	0.8227	More...
Q9UGU0	Transcription factor 20	DEG_SPOP_SBC_1	1673:1677	PPSST	SPOP	0.5462	More...
Q9UJ78	Zinc finger MYM-type protein 5	DEG_SPOP_SBC_1	489:493	PPSST	SPOP	0.8233	More...
Q9Y2H0	Disks large-associated protein 4	DEG_SPOP_SBC_1	66:70	PPSST	SPOP	0.9674	More...
Q76G19	PDZ domain-containing protein 4	DEG_SPOP_SBC_1	302:306	PPSST	SPOP	0.8947	More...
Q7L0X2	Glutamate-rich protein 6	DEG_SPOP_SBC_1	126:130	PPSST	SPOP	0.8085	More...
Q5VWI1	Transcription elongation regulator 1-like protein	DEG_SPOP_SBC_1	127:131	PPSST	SPOP	0.9468	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PPSST

Degron related mutations and impact score

Drug responses associated with PDZD4 mutations

All proteins holding degron of PPSST